| month | day | visitor | score | home | score |
|---|
| November | 2, 2021 | Warriors | 120 | Timberwolves | 125 |
| November | 4, 2021 | Clippers | 116 | Timberwolves | 125 |
| November | 6, 2021 | Timberwolves | 107 | Rockets | 108 |
| November | 9, 2021 | Jazz | 87 | Timberwolves | 114 |
| November | 10, 2021 | Timberwolves | 110 | Nuggets | 104 |
| November | 12, 2021 | Timberwolves | 113 | Warriors | 118 |
| November | 16, 2021 | Timberwolves | 97 | Suns | 91 |
| November | 17, 2021 | Timberwolves | 110 | Lakers | 118 |
| November | 18, 2021 | Knicks | 118 | Timberwolves | 110 |
| November | 19, 2021 | Pistons | 104 | Timberwolves | 113 |
| November | 20, 2021 | Nuggets | 101 | Timberwolves | 98 |
| November | 23, 2021 | Nuggets | 98 | Timberwolves | 103 |
| November | 27, 2021 | Clippers | 112 | Timberwolves | 120 |
| November | 30, 2021 | Clippers | 102 | Timberwolves | 116 |
| December | 3, 2021 | Lakers | 112 | Timberwolves | 106 |
| December | 4, 2021 | Timberwolves | 103 | Sonics | 106 |
| December | 5, 2021 | Timberwolves | 90 | Spurs | 95 |
| December | 11, 2021 | Timberwolves | 101 | Jazz | 102 |
| December | 12, 2021 | Timberwolves | 123 | Lakers | 103 |
| December | 13, 2021 | Timberwolves | 112 | Nuggets | 104 |
| December | 14, 2021 | Timberwolves | 89 | Spurs | 88 |
| December | 16, 2021 | Timberwolves | 102 | Clippers | 93 |
| December | 17, 2021 | Timberwolves | 93 | Bulls | 95 |
| December | 19, 2021 | Timberwolves | 92 | Jazz | 104 |
| December | 20, 2021 | Spurs | 97 | Timberwolves | 84 |
| December | 21, 2021 | Timberwolves | 97 | Heat | 144 |
| December | 22, 2021 | Timberwolves | 103 | Pistons | 105 |
| December | 24, 2021 | Jazz | 94 | Timberwolves | 119 |
| December | 25, 2021 | Suns | 98 | Timberwolves | 102 |
| December | 26, 2021 | Warriors | 109 | Timberwolves | 115 |
| January | 2, 2022 | Timberwolves | 100 | Nuggets | 109 |
| January | 3, 2022 | Timberwolves | 96 | Spurs | 107 |
| January | 5, 2022 | Rockets | 74 | Timberwolves | 125 |
| January | 10, 2022 | Suns | 95 | Timberwolves | 91 |
| January | 12, 2022 | Timberwolves | 84 | Clippers | 117 |
| January | 15, 2022 | Timberwolves | 84 | Suns | 96 |
| January | 19, 2022 | Timberwolves | 129 | Rockets | 123 |
| January | 20, 2022 | Jazz | 93 | Timberwolves | 116 |
| January | 21, 2022 | Timberwolves | 105 | Hornets | 100 |
| January | 22, 2022 | Timberwolves | 117 | Sonics | 123 |
| January | 23, 2022 | Celtics | 113 | Timberwolves | 124 |
| January | 24, 2022 | Rockets | 120 | Timberwolves | 101 |
| January | 26, 2022 | Timberwolves | 97 | Spurs | 109 |
| January | 28, 2022 | Timberwolves | 113 | Lakers | 118 |
| January | 30, 2022 | Nuggets | 109 | Timberwolves | 99 |
| January | 31, 2022 | Timberwolves | 91 | Jazz | 99 |
| February | 5, 2022 | Spurs | 111 | Timberwolves | 82 |
| February | 7, 2022 | Clippers | 94 | Timberwolves | 100 |
| February | 8, 2022 | 76ers | 97 | Timberwolves | 116 |
| February | 10, 2022 | Hornets | 86 | Timberwolves | 118 |
| February | 11, 2022 | Lakers | 97 | Timberwolves | 99 |
| February | 12, 2022 | Sonics | 96 | Timberwolves | 98 |
| February | 14, 2022 | Bulls | 93 | Timberwolves | 81 |
| February | 17, 2022 | Timberwolves | 93 | Suns | 121 |
| February | 18, 2022 | Timberwolves | 119 | Warriors | 136 |
| February | 23, 2022 | Jazz | 84 | Timberwolves | 100 |
| February | 24, 2022 | Timberwolves | 96 | Raptors | 119 |
| February | 26, 2022 | Rockets | 104 | Timberwolves | 105 |
| February | 27, 2022 | Timberwolves | 100 | Jazz | 93 |
| March | 2, 2022 | Timberwolves | 102 | Warriors | 119 |
| March | 3, 2022 | Timberwolves | 89 | Cavaliers | 106 |
| March | 4, 2022 | Sonics | 95 | Timberwolves | 83 |
| March | 7, 2022 | Timberwolves | 94 | 76ers | 119 |
| March | 11, 2022 | Cavaliers | 91 | Timberwolves | 106 |
| March | 12, 2022 | Timberwolves | 84 | Rockets | 118 |
| March | 15, 2022 | Lakers | 96 | Timberwolves | 124 |
| March | 16, 2022 | Timberwolves | 87 | Rockets | 105 |
| March | 19, 2022 | Sonics | 102 | Timberwolves | 92 |
| March | 21, 2022 | Timberwolves | | Sonics | |
| March | 22, 2022 | Lakers | | Timberwolves | |
| March | 23, 2022 | Grizzlies | | Timberwolves | |
| March | 25, 2022 | Warriors | | Timberwolves | |
| March | 28, 2022 | Heat | | Timberwolves | |
| March | 29, 2022 | Timberwolves | | Grizzlies | |
| April | 1, 2022 | Suns | | Timberwolves | |
| April | 3, 2022 | Raptors | | Timberwolves | |
| April | 9, 2022 | Timberwolves | | Clippers | |
| April | 12, 2022 | Sonics | | Timberwolves | |
| April | 14, 2022 | Timberwolves | | Celtics | |
| April | 16, 2022 | Spurs | | Timberwolves | |
| April | 17, 2022 | Timberwolves | | Knicks | |
| April | 20, 2022 | Timberwolves | | Nuggets | |