| month | day | visitor | score | home | score |
|---|
| November | 6, 2021 | Bulls | 104 | Sonics | 81 |
| November | 9, 2021 | Sonics | 106 | Celtics | 110 |
| November | 11, 2021 | Warriors | 117 | Sonics | 94 |
| November | 15, 2021 | Sonics | 96 | Clippers | 100 |
| November | 17, 2021 | Clippers | 94 | Sonics | 113 |
| November | 19, 2021 | Suns | 84 | Sonics | 110 |
| November | 22, 2021 | Cavaliers | 77 | Sonics | 111 |
| November | 24, 2021 | Sonics | 101 | Suns | 96 |
| November | 26, 2021 | Sonics | 109 | Nuggets | 106 |
| November | 27, 2021 | Sonics | 118 | 76ers | 109 |
| November | 28, 2021 | Sonics | 105 | Bulls | 93 |
| November | 30, 2021 | Rockets | 97 | Sonics | 90 |
| December | 4, 2021 | Timberwolves | 103 | Sonics | 106 |
| December | 5, 2021 | Sonics | 106 | Warriors | 114 |
| December | 6, 2021 | Sonics | 96 | Grizzlies | 93 |
| December | 9, 2021 | Sonics | 102 | Spurs | 100 |
| December | 12, 2021 | Sonics | 103 | Knicks | 113 |
| December | 13, 2021 | Jazz | 86 | Sonics | 103 |
| December | 14, 2021 | Sonics | 113 | Warriors | 116 |
| December | 17, 2021 | Sonics | 78 | Rockets | 93 |
| December | 19, 2021 | Spurs | 98 | Sonics | 91 |
| December | 22, 2021 | Suns | 94 | Sonics | 100 |
| December | 31, 2021 | Pistons | 91 | Sonics | 147 |
| January | 1, 2022 | Warriors | 101 | Sonics | 113 |
| January | 6, 2022 | Sonics | 100 | Clippers | 99 |
| January | 7, 2022 | Jazz | 82 | Sonics | 91 |
| January | 8, 2022 | Sonics | 91 | Suns | 104 |
| January | 11, 2022 | Sonics | 104 | Lakers | 98 |
| January | 12, 2022 | Spurs | 99 | Sonics | 91 |
| January | 14, 2022 | Sonics | 88 | Rockets | 101 |
| January | 15, 2022 | Jazz | 88 | Sonics | 95 |
| January | 16, 2022 | Sonics | 116 | Lakers | 118 |
| January | 17, 2022 | Lakers | 104 | Sonics | 112 |
| January | 18, 2022 | Sonics | 110 | Heat | 111 |
| January | 21, 2022 | Sonics | 106 | Clippers | 113 |
| January | 22, 2022 | Timberwolves | 117 | Sonics | 123 |
| January | 23, 2022 | Rockets | 105 | Sonics | 96 |
| January | 25, 2022 | Warriors | 104 | Sonics | 125 |
| January | 28, 2022 | Rockets | 106 | Sonics | 111 |
| January | 29, 2022 | Nuggets | 90 | Sonics | 109 |
| February | 6, 2022 | Heat | 117 | Sonics | 106 |
| February | 8, 2022 | Lakers | 86 | Sonics | 105 |
| February | 9, 2022 | Sonics | 96 | Nuggets | 104 |
| February | 11, 2022 | Sonics | 79 | Hornets | 78 |
| February | 12, 2022 | Sonics | 96 | Timberwolves | 98 |
| February | 14, 2022 | Nuggets | 102 | Sonics | 104 |
| February | 15, 2022 | Sonics | 94 | Spurs | 95 |
| February | 16, 2022 | Sonics | 85 | Nuggets | 91 |
| February | 17, 2022 | Lakers | 101 | Sonics | 104 |
| February | 21, 2022 | Clippers | 96 | Sonics | 115 |
| February | 22, 2022 | Sonics | 114 | Lakers | 99 |
| February | 23, 2022 | Sonics | 111 | Warriors | 110 |
| February | 25, 2022 | Knicks | 109 | Sonics | 126 |
| February | 26, 2022 | Clippers | 88 | Sonics | 91 |
| March | 4, 2022 | Sonics | 95 | Timberwolves | 83 |
| March | 5, 2022 | Sonics | 93 | Suns | 100 |
| March | 8, 2022 | Sonics | 103 | Rockets | 90 |
| March | 9, 2022 | Celtics | 107 | Sonics | 109 |
| March | 11, 2022 | Sonics | 98 | Spurs | 97 |
| March | 13, 2022 | Nuggets | 92 | Sonics | 114 |
| March | 14, 2022 | Sonics | 113 | Suns | 101 |
| March | 15, 2022 | Sonics | 95 | Spurs | 104 |
| March | 16, 2022 | Sonics | 93 | Cavaliers | 102 |
| March | 19, 2022 | Sonics | 102 | Timberwolves | 92 |
| March | 20, 2022 | Hornets | 85 | Sonics | 94 |
| March | 21, 2022 | Timberwolves | | Sonics | |
| March | 22, 2022 | Sonics | | Jazz | |
| March | 23, 2022 | 76ers | | Sonics | |
| March | 27, 2022 | Sonics | | Jazz | |
| March | 31, 2022 | Sonics | | Raptors | |
| April | 1, 2022 | Nuggets | | Sonics | |
| April | 2, 2022 | Spurs | | Sonics | |
| April | 4, 2022 | Sonics | | Rockets | |
| April | 5, 2022 | Lakers | | Sonics | |
| April | 6, 2022 | Grizzlies | | Sonics | |
| April | 7, 2022 | Clippers | | Sonics | |
| April | 9, 2022 | Jazz | | Sonics | |
| April | 12, 2022 | Sonics | | Timberwolves | |
| April | 15, 2022 | Suns | | Sonics | |
| April | 16, 2022 | Sonics | | Warriors | |
| April | 19, 2022 | Raptors | | Sonics | |
| April | 20, 2022 | Sonics | | Pistons | |