| month | day | visitor | score | home | score |
|---|
| November | 3, 2022 | Jazz | 111 | Lakers | 120 |
| November | 8, 2022 | Clippers | 88 | Lakers | 96 |
| November | 9, 2022 | Jazz | 124 | Lakers | 104 |
| November | 13, 2022 | Lakers | 97 | Clippers | 105 |
| November | 15, 2022 | Nuggets | 113 | Lakers | 121 |
| November | 19, 2022 | Pistons | 123 | Lakers | 114 |
| November | 21, 2022 | Lakers | 86 | Rockets | 112 |
| November | 26, 2022 | Lakers | 105 | Sonics | 115 |
| November | 27, 2022 | Timberwolves | 114 | Lakers | 95 |
| November | 28, 2022 | Suns | 91 | Lakers | 102 |
| November | 29, 2022 | Heat | 114 | Lakers | 92 |
| November | 30, 2022 | Lakers | 98 | Warriors | 121 |
| December | 1, 2022 | Lakers | 92 | Spurs | 101 |
| December | 2, 2022 | Lakers | 118 | Sonics | 113 |
| December | 5, 2022 | Lakers | 98 | Celtics | 123 |
| December | 6, 2022 | Warriors | 92 | Lakers | 116 |
| December | 7, 2022 | Spurs | 96 | Lakers | 80 |
| December | 8, 2022 | Lakers | 93 | Timberwolves | 128 |
| December | 9, 2022 | Lakers | 88 | Suns | 109 |
| December | 10, 2022 | Clippers | 116 | Lakers | 94 |
| December | 13, 2022 | Lakers | 102 | Rockets | 130 |
| December | 15, 2022 | Jazz | 113 | Lakers | 108 |
| December | 17, 2022 | Lakers | 74 | Spurs | 90 |
| December | 18, 2022 | Lakers | 89 | Nuggets | 120 |
| December | 19, 2022 | Lakers | 94 | Jazz | 125 |
| December | 20, 2022 | Lakers | 107 | Sonics | 97 |
| December | 22, 2022 | Timberwolves | 100 | Lakers | 116 |
| December | 29, 2022 | Lakers | 105 | Timberwolves | 102 |
| December | 30, 2022 | Sonics | 76 | Lakers | 113 |
| December | 31, 2022 | Timberwolves | 98 | Lakers | 94 |
| January | 1, 2023 | Lakers | 84 | Suns | 117 |
| January | 2, 2023 | Knicks | 120 | Lakers | 103 |
| January | 5, 2023 | Warriors | 117 | Lakers | 114 |
| January | 6, 2023 | Suns | 108 | Lakers | 126 |
| January | 7, 2023 | Lakers | 95 | Spurs | 103 |
| January | 10, 2023 | Lakers | 116 | Pistons | 125 |
| January | 12, 2023 | Clippers | 123 | Lakers | 106 |
| January | 16, 2023 | Lakers | 107 | Suns | 118 |
| January | 17, 2023 | Lakers | 93 | Heat | 137 |
| January | 18, 2023 | Hornets | 91 | Lakers | 97 |
| January | 19, 2023 | Grizzlies | 103 | Lakers | 100 |
| January | 21, 2023 | Lakers | 95 | 76ers | 102 |
| January | 22, 2023 | Suns | 100 | Lakers | 102 |
| January | 23, 2023 | Rockets | 105 | Lakers | 104 |
| January | 27, 2023 | Lakers | 124 | Warriors | 105 |
| January | 31, 2023 | Lakers | 111 | Knicks | 121 |
| February | 6, 2023 | Lakers | 114 | Raptors | 121 |
| February | 7, 2023 | Lakers | 89 | Bulls | 96 |
| February | 8, 2023 | Lakers | 91 | Timberwolves | 115 |
| February | 10, 2023 | Lakers | 95 | Timberwolves | 111 |
| February | 11, 2023 | Nuggets | 88 | Lakers | 121 |
| February | 12, 2023 | Rockets | 101 | Lakers | 105 |
| February | 13, 2023 | Lakers | 85 | Grizzlies | 110 |
| February | 15, 2023 | 76ers | 85 | Lakers | 117 |
| February | 17, 2023 | Spurs | 105 | Lakers | 88 |
| February | 18, 2023 | Lakers | 94 | Spurs | 102 |
| February | 21, 2023 | Spurs | 78 | Lakers | 108 |
| February | 23, 2023 | Cavaliers | 97 | Lakers | 114 |
| February | 24, 2023 | Raptors | 112 | Lakers | 100 |
| March | 1, 2023 | Bulls | 113 | Lakers | 121 |
| March | 3, 2023 | Lakers | 100 | Rockets | 107 |
| March | 5, 2023 | Rockets | 96 | Lakers | 110 |
| March | 9, 2023 | Nuggets | 105 | Lakers | 97 |
| March | 10, 2023 | Lakers | 102 | Nuggets | 134 |
| March | 11, 2023 | Sonics | 110 | Lakers | 114 |
| March | 13, 2023 | Lakers | 100 | Jazz | 107 |
| March | 18, 2023 | Lakers | 120 | Warriors | 117 |
| March | 19, 2023 | Lakers | 103 | Nuggets | 128 |
| March | 20, 2023 | Jazz | 118 | Lakers | 108 |
| March | 24, 2023 | Lakers | 107 | Clippers | 91 |
| March | 25, 2023 | Clippers | 116 | Lakers | 111 |
| March | 26, 2023 | Clippers | 95 | Lakers | 125 |
| March | 30, 2023 | Lakers | 125 | Rockets | 110 |
| March | 31, 2023 | Lakers | 99 | Cavaliers | 123 |
| April | 1, 2023 | Lakers | 119 | Warriors | 129 |
| April | 5, 2023 | Lakers | 125 | Sonics | 103 |
| April | 7, 2023 | Celtics | 124 | Lakers | 109 |
| April | 12, 2023 | Nuggets | 110 | Lakers | 97 |
| April | 16, 2023 | Sonics | 89 | Lakers | 132 |
| April | 17, 2023 | Warriors | 121 | Lakers | 128 |
| April | 18, 2023 | Lakers | 107 | Suns | 111 |
| April | 19, 2023 | Lakers | 80 | Hornets | 119 |