| month | day | visitor | score | home | score |
|---|
| November | 2, 2022 | Pistons | 118 | Lakers | 104 |
| November | 4, 2022 | 76ers | 88 | Lakers | 111 |
| November | 8, 2022 | Heat | 120 | Lakers | 91 |
| November | 9, 2022 | Lakers | 95 | Warriors | 110 |
| November | 10, 2022 | Hornets | 101 | Lakers | 116 |
| November | 11, 2022 | Lakers | 104 | Nuggets | 124 |
| November | 12, 2022 | Clippers | 98 | Lakers | 87 |
| November | 13, 2022 | Lakers | 105 | Nuggets | 112 |
| November | 14, 2022 | Bulls | 132 | Lakers | 96 |
| November | 17, 2022 | Timberwolves | 110 | Lakers | 115 |
| November | 20, 2022 | Lakers | 108 | Jazz | 101 |
| November | 21, 2022 | Lakers | 101 | Rockets | 123 |
| November | 24, 2022 | Jazz | 118 | Lakers | 114 |
| November | 27, 2022 | Lakers | 93 | Raptors | 114 |
| November | 29, 2022 | Jazz | 115 | Lakers | 104 |
| December | 3, 2022 | Lakers | 118 | Timberwolves | 126 |
| December | 4, 2022 | Rockets | 129 | Lakers | 105 |
| December | 6, 2022 | Spurs | 101 | Lakers | 77 |
| December | 8, 2022 | Lakers | 90 | Grizzlies | 92 |
| December | 10, 2022 | Lakers | 94 | Warriors | 127 |
| December | 12, 2022 | Timberwolves | 118 | Lakers | 107 |
| December | 13, 2022 | Clippers | 108 | Lakers | 98 |
| December | 16, 2022 | Lakers | 70 | Suns | 119 |
| December | 17, 2022 | Lakers | 80 | Spurs | 97 |
| December | 21, 2022 | Suns | 118 | Lakers | 82 |
| December | 24, 2022 | Nuggets | 108 | Lakers | 111 |
| December | 27, 2022 | Rockets | 117 | Lakers | 94 |
| December | 28, 2022 | Lakers | 99 | Clippers | 101 |
| December | 31, 2022 | Lakers | 92 | Spurs | 90 |
| January | 3, 2023 | Nuggets | 113 | Lakers | 97 |
| January | 4, 2023 | Clippers | 91 | Lakers | 95 |
| January | 9, 2023 | Lakers | 77 | Spurs | 80 |
| January | 11, 2023 | Sonics | 108 | Lakers | 116 |
| January | 13, 2023 | Clippers | 91 | Lakers | 105 |
| January | 14, 2023 | Lakers | 96 | 76ers | 93 |
| January | 16, 2023 | Sonics | 102 | Lakers | 121 |
| January | 17, 2023 | Lakers | 97 | Sonics | 124 |
| January | 21, 2023 | Lakers | 108 | Nuggets | 120 |
| January | 25, 2023 | Knicks | 118 | Lakers | 98 |
| January | 28, 2023 | Timberwolves | 95 | Lakers | 102 |
| January | 29, 2023 | Warriors | 117 | Lakers | 124 |
| January | 30, 2023 | Lakers | 93 | Suns | 97 |
| February | 7, 2023 | Lakers | | Hornets | |
| February | 8, 2023 | Lakers | | Sonics | |
| February | 9, 2023 | Suns | | Lakers | |
| February | 11, 2023 | Lakers | | Timberwolves | |
| February | 12, 2023 | Warriors | | Lakers | |
| February | 13, 2023 | Clippers | | Lakers | |
| February | 16, 2023 | Spurs | | Lakers | |
| February | 17, 2023 | Lakers | | Sonics | |
| February | 18, 2023 | Celtics | | Lakers | |
| February | 19, 2023 | Lakers | | Rockets | |
| February | 22, 2023 | Sonics | | Lakers | |
| February | 23, 2023 | Cavaliers | | Lakers | |
| February | 27, 2023 | Lakers | | Heat | |
| February | 28, 2023 | Jazz | | Lakers | |
| March | 1, 2023 | Nuggets | | Lakers | |
| March | 3, 2023 | Lakers | | Warriors | |
| March | 4, 2023 | Lakers | | Pistons | |
| March | 6, 2023 | Lakers | | Rockets | |
| March | 8, 2023 | Lakers | | Spurs | |
| March | 10, 2023 | Lakers | | Warriors | |
| March | 11, 2023 | Lakers | | Celtics | |
| March | 13, 2023 | Lakers | | Bulls | |
| March | 15, 2023 | Lakers | | Timberwolves | |
| March | 17, 2023 | Raptors | | Lakers | |
| March | 21, 2023 | Suns | | Lakers | |
| March | 22, 2023 | Lakers | | Timberwolves | |
| March | 24, 2023 | Grizzlies | | Lakers | |
| March | 25, 2023 | Lakers | | Cavaliers | |
| March | 29, 2023 | Nuggets | | Lakers | |
| March | 30, 2023 | Lakers | | Suns | |
| March | 31, 2023 | Lakers | | Suns | |
| April | 1, 2023 | Jazz | | Lakers | |
| April | 5, 2023 | Lakers | | Sonics | |
| April | 7, 2023 | Rockets | | Lakers | |
| April | 8, 2023 | Lakers | | Rockets | |
| April | 11, 2023 | Warriors | | Lakers | |
| April | 13, 2023 | Lakers | | Clippers | |
| April | 14, 2023 | Lakers | | Knicks | |
| April | 15, 2023 | Lakers | | Jazz | |
| April | 20, 2023 | Spurs | | Lakers | |