| month | day | visitor | score | home | score |
|---|
| November | 2, 2021 | Pistons | 114 | Lakers | 105 |
| November | 4, 2021 | 76ers | 101 | Lakers | 105 |
| November | 8, 2021 | Heat | 127 | Lakers | 93 |
| November | 9, 2021 | Lakers | 107 | Warriors | 118 |
| November | 10, 2021 | Hornets | 92 | Lakers | 79 |
| November | 11, 2021 | Lakers | 118 | Nuggets | 122 |
| November | 12, 2021 | Clippers | 90 | Lakers | 102 |
| November | 13, 2021 | Lakers | 114 | Nuggets | 108 |
| November | 14, 2021 | Bulls | 92 | Lakers | 103 |
| November | 17, 2021 | Timberwolves | 110 | Lakers | 118 |
| November | 20, 2021 | Lakers | 104 | Jazz | 112 |
| November | 21, 2021 | Lakers | 106 | Rockets | 112 |
| November | 24, 2021 | Jazz | 93 | Lakers | 96 |
| November | 27, 2021 | Lakers | 115 | Raptors | 112 |
| November | 29, 2021 | Jazz | 94 | Lakers | 104 |
| December | 3, 2021 | Lakers | 112 | Timberwolves | 106 |
| December | 4, 2021 | Rockets | 116 | Lakers | 103 |
| December | 6, 2021 | Spurs | 91 | Lakers | 110 |
| December | 8, 2021 | Lakers | 99 | Grizzlies | 136 |
| December | 10, 2021 | Lakers | 111 | Warriors | 127 |
| December | 12, 2021 | Timberwolves | 123 | Lakers | 103 |
| December | 13, 2021 | Clippers | 100 | Lakers | 123 |
| December | 16, 2021 | Lakers | 102 | Suns | 122 |
| December | 17, 2021 | Lakers | 79 | Spurs | 90 |
| December | 21, 2021 | Suns | 98 | Lakers | 94 |
| December | 24, 2021 | Nuggets | 103 | Lakers | 80 |
| December | 27, 2021 | Rockets | 115 | Lakers | 96 |
| December | 28, 2021 | Lakers | 90 | Clippers | 105 |
| December | 31, 2021 | Lakers | 79 | Spurs | 107 |
| January | 3, 2022 | Nuggets | 107 | Lakers | 96 |
| January | 4, 2022 | Clippers | 96 | Lakers | 108 |
| January | 9, 2022 | Lakers | 90 | Spurs | 93 |
| January | 11, 2022 | Sonics | 104 | Lakers | 98 |
| January | 13, 2022 | Clippers | 99 | Lakers | 100 |
| January | 14, 2022 | Lakers | 97 | 76ers | 120 |
| January | 16, 2022 | Sonics | 116 | Lakers | 118 |
| January | 17, 2022 | Lakers | 104 | Sonics | 112 |
| January | 21, 2022 | Lakers | 106 | Nuggets | 89 |
| January | 25, 2022 | Knicks | 103 | Lakers | 98 |
| January | 28, 2022 | Timberwolves | 113 | Lakers | 118 |
| January | 29, 2022 | Warriors | 109 | Lakers | 117 |
| January | 30, 2022 | Lakers | 91 | Suns | 96 |
| February | 7, 2022 | Lakers | 83 | Hornets | 99 |
| February | 8, 2022 | Lakers | 86 | Sonics | 105 |
| February | 9, 2022 | Suns | 115 | Lakers | 104 |
| February | 11, 2022 | Lakers | 97 | Timberwolves | 99 |
| February | 12, 2022 | Warriors | 113 | Lakers | 108 |
| February | 13, 2022 | Clippers | 117 | Lakers | 84 |
| February | 16, 2022 | Spurs | 97 | Lakers | 65 |
| February | 17, 2022 | Lakers | 101 | Sonics | 104 |
| February | 18, 2022 | Celtics | 126 | Lakers | 110 |
| February | 19, 2022 | Lakers | 87 | Rockets | 118 |
| February | 22, 2022 | Sonics | 114 | Lakers | 99 |
| February | 23, 2022 | Cavaliers | 87 | Lakers | 114 |
| February | 27, 2022 | Lakers | 94 | Heat | 119 |
| February | 28, 2022 | Jazz | 94 | Lakers | 90 |
| March | 1, 2022 | Nuggets | 120 | Lakers | 111 |
| March | 3, 2022 | Lakers | 87 | Warriors | 126 |
| March | 4, 2022 | Lakers | 97 | Pistons | 107 |
| March | 6, 2022 | Lakers | 91 | Rockets | 114 |
| March | 8, 2022 | Lakers | 78 | Spurs | 94 |
| March | 10, 2022 | Lakers | 98 | Warriors | 111 |
| March | 11, 2022 | Lakers | 83 | Celtics | 141 |
| March | 13, 2022 | Lakers | 89 | Bulls | 111 |
| March | 15, 2022 | Lakers | 96 | Timberwolves | 124 |
| March | 17, 2022 | Raptors | 132 | Lakers | 92 |
| March | 21, 2022 | Suns | | Lakers | |
| March | 22, 2022 | Lakers | | Timberwolves | |
| March | 24, 2022 | Grizzlies | | Lakers | |
| March | 25, 2022 | Lakers | | Cavaliers | |
| March | 29, 2022 | Nuggets | | Lakers | |
| March | 30, 2022 | Lakers | | Suns | |
| March | 31, 2022 | Lakers | | Suns | |
| April | 1, 2022 | Jazz | | Lakers | |
| April | 5, 2022 | Lakers | | Sonics | |
| April | 7, 2022 | Rockets | | Lakers | |
| April | 8, 2022 | Lakers | | Rockets | |
| April | 11, 2022 | Warriors | | Lakers | |
| April | 13, 2022 | Lakers | | Clippers | |
| April | 14, 2022 | Lakers | | Knicks | |
| April | 15, 2022 | Lakers | | Jazz | |
| April | 20, 2022 | Spurs | | Lakers | |