| month | day | visitor | score | home | score |
|---|
| November | 5, 2021 | Warriors | 95 | Rockets | 99 |
| November | 6, 2021 | Timberwolves | 107 | Rockets | 108 |
| November | 7, 2021 | Spurs | 83 | Rockets | 87 |
| November | 10, 2021 | Warriors | 117 | Rockets | 108 |
| November | 11, 2021 | Rockets | 86 | Clippers | 104 |
| November | 12, 2021 | Spurs | 90 | Rockets | 95 |
| November | 14, 2021 | Rockets | 88 | Spurs | 81 |
| November | 16, 2021 | Jazz | 100 | Rockets | 82 |
| November | 19, 2021 | Nuggets | 92 | Rockets | 112 |
| November | 21, 2021 | Lakers | 106 | Rockets | 112 |
| November | 22, 2021 | Clippers | 83 | Rockets | 106 |
| November | 25, 2021 | Warriors | 97 | Rockets | 103 |
| November | 27, 2021 | Rockets | 104 | Celtics | 120 |
| November | 30, 2021 | Rockets | 97 | Sonics | 90 |
| December | 1, 2021 | Rockets | 99 | Nuggets | 114 |
| December | 2, 2021 | Knicks | 110 | Rockets | 106 |
| December | 3, 2021 | Rockets | 89 | Suns | 80 |
| December | 4, 2021 | Rockets | 116 | Lakers | 103 |
| December | 6, 2021 | Celtics | 100 | Rockets | 104 |
| December | 7, 2021 | Rockets | 89 | Spurs | 83 |
| December | 9, 2021 | 76ers | 107 | Rockets | 100 |
| December | 11, 2021 | Rockets | 84 | Spurs | 93 |
| December | 15, 2021 | Rockets | 85 | Spurs | 88 |
| December | 17, 2021 | Sonics | 78 | Rockets | 93 |
| December | 19, 2021 | Rockets | 102 | Nuggets | 105 |
| December | 20, 2021 | Grizzlies | 89 | Rockets | 92 |
| December | 23, 2021 | Rockets | 113 | Heat | 115 |
| December | 24, 2021 | Bulls | 117 | Rockets | 97 |
| December | 25, 2021 | Rockets | 103 | Hornets | 92 |
| December | 27, 2021 | Rockets | 115 | Lakers | 96 |
| January | 1, 2022 | Rockets | 86 | Jazz | 103 |
| January | 2, 2022 | Rockets | 97 | Knicks | 125 |
| January | 5, 2022 | Rockets | 74 | Timberwolves | 125 |
| January | 6, 2022 | Suns | 88 | Rockets | 101 |
| January | 10, 2022 | Rockets | 117 | Pistons | 100 |
| January | 13, 2022 | Hornets | 81 | Rockets | 93 |
| January | 14, 2022 | Sonics | 88 | Rockets | 101 |
| January | 18, 2022 | Rockets | 99 | Warriors | 103 |
| January | 19, 2022 | Timberwolves | 129 | Rockets | 123 |
| January | 20, 2022 | Raptors | 112 | Rockets | 119 |
| January | 23, 2022 | Rockets | 105 | Sonics | 96 |
| January | 24, 2022 | Rockets | 120 | Timberwolves | 101 |
| January | 26, 2022 | Rockets | 114 | Nuggets | 118 |
| January | 27, 2022 | Clippers | 108 | Rockets | 104 |
| January | 28, 2022 | Rockets | 106 | Sonics | 111 |
| February | 5, 2022 | Rockets | 98 | Jazz | 90 |
| February | 6, 2022 | Rockets | 94 | Warriors | 115 |
| February | 12, 2022 | Suns | 115 | Rockets | 110 |
| February | 14, 2022 | Rockets | 108 | Clippers | 116 |
| February | 16, 2022 | Jazz | 70 | Rockets | 101 |
| February | 19, 2022 | Lakers | 87 | Rockets | 118 |
| February | 20, 2022 | Nuggets | 95 | Rockets | 115 |
| February | 21, 2022 | Rockets | 102 | Spurs | 95 |
| February | 24, 2022 | Nuggets | 114 | Rockets | 107 |
| February | 26, 2022 | Rockets | 104 | Timberwolves | 105 |
| February | 28, 2022 | Clippers | 93 | Rockets | 103 |
| March | 4, 2022 | Clippers | 98 | Rockets | 107 |
| March | 5, 2022 | Rockets | 107 | Nuggets | 125 |
| March | 6, 2022 | Lakers | 91 | Rockets | 114 |
| March | 7, 2022 | Rockets | 107 | Warriors | 93 |
| March | 8, 2022 | Sonics | 103 | Rockets | 90 |
| March | 9, 2022 | Rockets | 110 | Cavaliers | 119 |
| March | 12, 2022 | Timberwolves | 84 | Rockets | 118 |
| March | 13, 2022 | Heat | 112 | Rockets | 106 |
| March | 14, 2022 | Rockets | 97 | Jazz | 104 |
| March | 16, 2022 | Timberwolves | 87 | Rockets | 105 |
| March | 20, 2022 | Rockets | 122 | Clippers | 115 |
| March | 22, 2022 | Rockets | | Suns | |
| March | 24, 2022 | Rockets | | Suns | |
| March | 25, 2022 | Pistons | | Rockets | |
| March | 28, 2022 | Rockets | | Grizzlies | |
| March | 30, 2022 | Cavaliers | | Rockets | |
| April | 2, 2022 | Jazz | | Rockets | |
| April | 3, 2022 | Rockets | | Jazz | |
| April | 4, 2022 | Sonics | | Rockets | |
| April | 5, 2022 | Rockets | | Raptors | |
| April | 7, 2022 | Rockets | | Lakers | |
| April | 8, 2022 | Lakers | | Rockets | |
| April | 9, 2022 | Rockets | | 76ers | |
| April | 12, 2022 | Rockets | | Bulls | |
| April | 17, 2022 | Jazz | | Rockets | |
| April | 19, 2022 | Suns | | Rockets | |