| month | day | visitor | score | home | score |
|---|
| November | 2, 2022 | Spurs | 82 | Celtics | 103 |
| November | 3, 2022 | Spurs | 88 | Jazz | 74 |
| November | 7, 2022 | Spurs | 110 | Rockets | 89 |
| November | 8, 2022 | Nuggets | 89 | Spurs | 93 |
| November | 10, 2022 | Spurs | 95 | Suns | 99 |
| November | 12, 2022 | Spurs | 111 | Rockets | 108 |
| November | 13, 2022 | Spurs | 92 | Jazz | 73 |
| November | 14, 2022 | Rockets | 96 | Spurs | 99 |
| November | 18, 2022 | Spurs | 97 | Nuggets | 112 |
| November | 21, 2022 | Spurs | 95 | Grizzlies | 93 |
| November | 27, 2022 | Spurs | 83 | Jazz | 92 |
| November | 29, 2022 | Spurs | 107 | Suns | 84 |
| November | 30, 2022 | Spurs | 102 | Pistons | 106 |
| December | 2, 2022 | Spurs | 92 | Nuggets | 93 |
| December | 5, 2022 | Timberwolves | 86 | Spurs | 98 |
| December | 6, 2022 | Spurs | 101 | Lakers | 77 |
| December | 7, 2022 | Rockets | 78 | Spurs | 90 |
| December | 9, 2022 | Sonics | 88 | Spurs | 87 |
| December | 10, 2022 | Jazz | 91 | Spurs | 97 |
| December | 11, 2022 | Rockets | 80 | Spurs | 105 |
| December | 12, 2022 | Suns | 89 | Spurs | 92 |
| December | 14, 2022 | Timberwolves | 69 | Spurs | 95 |
| December | 15, 2022 | Rockets | 98 | Spurs | 87 |
| December | 16, 2022 | Knicks | 111 | Spurs | 76 |
| December | 17, 2022 | Lakers | 80 | Spurs | 97 |
| December | 18, 2022 | 76ers | 82 | Spurs | 99 |
| December | 19, 2022 | Spurs | 85 | Sonics | 94 |
| December | 20, 2022 | Spurs | 90 | Timberwolves | 96 |
| December | 25, 2022 | Spurs | 85 | Clippers | 90 |
| December | 26, 2022 | Spurs | 78 | Jazz | 91 |
| December | 29, 2022 | Spurs | 89 | Nuggets | 100 |
| December | 30, 2022 | Clippers | 102 | Spurs | 99 |
| December | 31, 2022 | Lakers | 92 | Spurs | 90 |
| January | 3, 2023 | Timberwolves | 85 | Spurs | 88 |
| January | 7, 2023 | Spurs | 84 | Nuggets | 97 |
| January | 8, 2023 | Spurs | 73 | Clippers | 74 |
| January | 9, 2023 | Lakers | 77 | Spurs | 80 |
| January | 11, 2023 | Heat | 83 | Spurs | 104 |
| January | 12, 2023 | Spurs | 84 | Sonics | 109 |
| January | 19, 2023 | Raptors | 89 | Spurs | 96 |
| January | 23, 2023 | Warriors | 69 | Spurs | 88 |
| January | 24, 2023 | Spurs | 97 | 76ers | 76 |
| January | 25, 2023 | Cavaliers | 95 | Spurs | 85 |
| January | 26, 2023 | Timberwolves | 107 | Spurs | 91 |
| February | 5, 2023 | Spurs | | Timberwolves | |
| February | 6, 2023 | Spurs | | Knicks | |
| February | 9, 2023 | Jazz | | Spurs | |
| February | 12, 2023 | Grizzlies | | Spurs | |
| February | 15, 2023 | Sonics | | Spurs | |
| February | 16, 2023 | Spurs | | Lakers | |
| February | 18, 2023 | Bulls | | Spurs | |
| February | 20, 2023 | Warriors | | Spurs | |
| February | 21, 2023 | Rockets | | Spurs | |
| February | 22, 2023 | Spurs | | Hornets | |
| February | 24, 2023 | Pistons | | Spurs | |
| February | 26, 2023 | Hornets | | Spurs | |
| February | 28, 2023 | Nuggets | | Spurs | |
| March | 1, 2023 | Spurs | | Warriors | |
| March | 3, 2023 | Jazz | | Spurs | |
| March | 4, 2023 | Spurs | | Heat | |
| March | 5, 2023 | Clippers | | Spurs | |
| March | 7, 2023 | Suns | | Spurs | |
| March | 8, 2023 | Lakers | | Spurs | |
| March | 10, 2023 | Spurs | | Nuggets | |
| March | 11, 2023 | Sonics | | Spurs | |
| March | 15, 2023 | Sonics | | Spurs | |
| March | 18, 2023 | Suns | | Spurs | |
| March | 19, 2023 | Warriors | | Spurs | |
| March | 20, 2023 | Spurs | | Raptors | |
| March | 22, 2023 | Spurs | | Warriors | |
| March | 24, 2023 | Spurs | | Bulls | |
| March | 29, 2023 | Spurs | | Jazz | |
| March | 31, 2023 | Spurs | | Warriors | |
| April | 1, 2023 | Celtics | | Spurs | |
| April | 2, 2023 | Spurs | | Sonics | |
| April | 6, 2023 | Suns | | Spurs | |
| April | 8, 2023 | Spurs | | Clippers | |
| April | 9, 2023 | Spurs | | Suns | |
| April | 11, 2023 | Spurs | | Clippers | |
| April | 16, 2023 | Spurs | | Timberwolves | |
| April | 18, 2023 | Spurs | | Cavaliers | |
| April | 20, 2023 | Spurs | | Lakers | |