| month | day | visitor | score | home | score |
|---|
| November | 2, 2022 | Hornets | 78 | Spurs | 99 |
| November | 3, 2022 | Sonics | 73 | Spurs | 100 |
| November | 4, 2022 | Warriors | 109 | Spurs | 98 |
| November | 5, 2022 | Nuggets | 86 | Spurs | 95 |
| November | 6, 2022 | Spurs | 97 | Suns | 93 |
| November | 10, 2022 | Timberwolves | 101 | Spurs | 92 |
| November | 13, 2022 | Spurs | 101 | Rockets | 94 |
| November | 20, 2022 | Bulls | 90 | Spurs | 96 |
| November | 22, 2022 | Spurs | 87 | Clippers | 83 |
| November | 23, 2022 | Spurs | 84 | Clippers | 96 |
| November | 24, 2022 | Spurs | 92 | Pistons | 119 |
| November | 27, 2022 | Spurs | 102 | Sonics | 92 |
| November | 28, 2022 | Warriors | 98 | Spurs | 90 |
| November | 29, 2022 | Spurs | 95 | 76ers | 90 |
| November | 30, 2022 | Rockets | 92 | Spurs | 84 |
| December | 1, 2022 | Lakers | 92 | Spurs | 101 |
| December | 5, 2022 | Spurs | 115 | Raptors | 90 |
| December | 7, 2022 | Spurs | 96 | Lakers | 80 |
| December | 8, 2022 | Spurs | 87 | Jazz | 79 |
| December | 9, 2022 | Spurs | 78 | Timberwolves | 90 |
| December | 10, 2022 | Sonics | 83 | Spurs | 121 |
| December | 11, 2022 | Spurs | 97 | Jazz | 100 |
| December | 14, 2022 | Timberwolves | 105 | Spurs | 108 |
| December | 15, 2022 | Timberwolves | 115 | Spurs | 74 |
| December | 17, 2022 | Lakers | 74 | Spurs | 90 |
| December | 18, 2022 | Spurs | 103 | Timberwolves | 105 |
| December | 21, 2022 | Spurs | 81 | Grizzlies | 95 |
| December | 23, 2022 | Rockets | 77 | Spurs | 93 |
| December | 26, 2022 | Spurs | 103 | Jazz | 75 |
| December | 30, 2022 | Spurs | 87 | Nuggets | 108 |
| December | 31, 2022 | Nuggets | 90 | Spurs | 93 |
| January | 1, 2023 | Spurs | 92 | Jazz | 113 |
| January | 3, 2023 | Jazz | 81 | Spurs | 98 |
| January | 4, 2023 | Spurs | 103 | Sonics | 96 |
| January | 5, 2023 | Clippers | 76 | Spurs | 103 |
| January | 7, 2023 | Lakers | 95 | Spurs | 103 |
| January | 9, 2023 | Jazz | 88 | Spurs | 97 |
| January | 11, 2023 | Spurs | 94 | Timberwolves | 103 |
| January | 13, 2023 | Spurs | 97 | Cavaliers | 107 |
| January | 15, 2023 | Suns | 92 | Spurs | 89 |
| January | 20, 2023 | Spurs | 86 | Suns | 82 |
| January | 21, 2023 | Spurs | 82 | Bulls | 102 |
| January | 23, 2023 | Suns | 74 | Spurs | 110 |
| January | 27, 2023 | Suns | 81 | Spurs | 85 |
| January | 30, 2023 | Spurs | 93 | Warriors | 110 |
| January | 31, 2023 | Heat | 91 | Spurs | 89 |
| February | 5, 2023 | Celtics | 96 | Spurs | 92 |
| February | 9, 2023 | Rockets | 122 | Spurs | 114 |
| February | 12, 2023 | Spurs | 87 | Jazz | 99 |
| February | 13, 2023 | Pistons | 100 | Spurs | 103 |
| February | 14, 2023 | Rockets | 101 | Spurs | 91 |
| February | 15, 2023 | Spurs | 81 | Knicks | 98 |
| February | 17, 2023 | Spurs | 105 | Lakers | 88 |
| February | 18, 2023 | Lakers | 94 | Spurs | 102 |
| February | 19, 2023 | Spurs | 67 | Heat | 114 |
| February | 20, 2023 | Spurs | 72 | Warriors | 111 |
| February | 21, 2023 | Spurs | 78 | Lakers | 108 |
| February | 23, 2023 | Spurs | 94 | Celtics | 100 |
| February | 28, 2023 | Spurs | 79 | Nuggets | 92 |
| March | 5, 2023 | Grizzlies | 79 | Spurs | 83 |
| March | 6, 2023 | Spurs | 109 | Rockets | 115 |
| March | 7, 2023 | Clippers | 80 | Spurs | 103 |
| March | 8, 2023 | Raptors | 81 | Spurs | 103 |
| March | 12, 2023 | Spurs | 81 | Clippers | 89 |
| March | 15, 2023 | Cavaliers | 82 | Spurs | 109 |
| March | 18, 2023 | Spurs | 91 | Nuggets | 96 |
| March | 19, 2023 | Spurs | 73 | Hornets | 89 |
| March | 21, 2023 | Sonics | 76 | Spurs | 93 |
| March | 24, 2023 | Rockets | 117 | Spurs | 88 |
| March | 27, 2023 | Spurs | 81 | Suns | 89 |
| March | 28, 2023 | Spurs | 71 | Clippers | 92 |
| March | 30, 2023 | Jazz | 93 | Spurs | 95 |
| April | 1, 2023 | Sonics | 83 | Spurs | 106 |
| April | 2, 2023 | Spurs | 82 | Nuggets | 100 |
| April | 3, 2023 | Spurs | 80 | Warriors | 103 |
| April | 8, 2023 | Warriors | 107 | Spurs | 97 |
| April | 10, 2023 | Spurs | 99 | Sonics | 74 |
| April | 11, 2023 | Timberwolves | 74 | Spurs | 105 |
| April | 13, 2023 | Suns | 103 | Spurs | 83 |
| April | 14, 2023 | Spurs | 97 | Nuggets | 104 |
| April | 15, 2023 | 76ers | 84 | Spurs | 90 |
| April | 18, 2023 | Knicks | 91 | Spurs | 112 |
| Post | 1, 2023 | Spurs | 83 | Rockets | 117 |
| Post | 2, 2023 | Spurs | 74 | Rockets | 93 |
| Post | 3, 2023 | Rockets | 88 | Spurs | 92 |
| Post | 4, 2023 | Rockets | 108 | Spurs | 95 |
| Post | 5, 2023 | Spurs | 97 | Rockets | 99 |
| Post | 6, 2023 | Rockets | | Spurs | |
| Post | 7, 2023 | Spurs | | Rockets | |