| month | day | visitor | score | home | score |
|---|
| November | 2, 2021 | Knicks | 90 | Hornets | 96 |
| November | 5, 2021 | Suns | 92 | Knicks | 96 |
| November | 8, 2021 | Knicks | 119 | Raptors | 109 |
| November | 12, 2021 | Knicks | 118 | Raptors | 103 |
| November | 13, 2021 | Cavaliers | 101 | Knicks | 119 |
| November | 16, 2021 | Celtics | 111 | Knicks | 107 |
| November | 17, 2021 | Heat | 114 | Knicks | 105 |
| November | 18, 2021 | Knicks | 118 | Timberwolves | 110 |
| November | 20, 2021 | Knicks | 133 | Pistons | 101 |
| November | 22, 2021 | Knicks | 115 | Grizzlies | 117 |
| November | 26, 2021 | Knicks | 95 | Celtics | 116 |
| November | 28, 2021 | Heat | 129 | Knicks | 107 |
| December | 2, 2021 | Knicks | 110 | Rockets | 106 |
| December | 3, 2021 | Clippers | 85 | Knicks | 111 |
| December | 4, 2021 | Hornets | 68 | Knicks | 108 |
| December | 5, 2021 | Knicks | 105 | 76ers | 128 |
| December | 7, 2021 | Knicks | 102 | Grizzlies | 111 |
| December | 8, 2021 | Knicks | 100 | Hornets | 90 |
| December | 10, 2021 | Knicks | 97 | Suns | 101 |
| December | 12, 2021 | Sonics | 103 | Knicks | 113 |
| December | 15, 2021 | Warriors | 96 | Knicks | 105 |
| December | 16, 2021 | Knicks | 109 | Spurs | 108 |
| December | 18, 2021 | Celtics | 127 | Knicks | 114 |
| December | 21, 2021 | Raptors | 105 | Knicks | 108 |
| December | 23, 2021 | Pistons | 104 | Knicks | 106 |
| December | 24, 2021 | Knicks | 106 | 76ers | 109 |
| December | 26, 2021 | Raptors | 118 | Knicks | 116 |
| December | 28, 2021 | 76ers | 103 | Knicks | 104 |
| December | 29, 2021 | Knicks | 107 | 76ers | 95 |
| January | 1, 2022 | Knicks | 110 | Hornets | 96 |
| January | 2, 2022 | Rockets | 97 | Knicks | 125 |
| January | 4, 2022 | 76ers | 118 | Knicks | 116 |
| January | 6, 2022 | Raptors | 107 | Knicks | 128 |
| January | 8, 2022 | Knicks | 118 | Nuggets | 115 |
| January | 10, 2022 | Knicks | 93 | Clippers | 96 |
| January | 12, 2022 | Pistons | 101 | Knicks | 125 |
| January | 13, 2022 | Knicks | 109 | Celtics | 113 |
| January | 15, 2022 | Celtics | 117 | Knicks | 95 |
| January | 16, 2022 | Knicks | 78 | Bulls | 91 |
| January | 17, 2022 | Jazz | 85 | Knicks | 107 |
| January | 19, 2022 | 76ers | 129 | Knicks | 113 |
| January | 23, 2022 | Nuggets | 108 | Knicks | 112 |
| January | 25, 2022 | Knicks | 103 | Lakers | 98 |
| February | 5, 2022 | Knicks | 103 | Raptors | 135 |
| February | 6, 2022 | Spurs | 98 | Knicks | 116 |
| February | 7, 2022 | Knicks | 116 | Cavaliers | 127 |
| February | 9, 2022 | Knicks | 118 | Cavaliers | 105 |
| February | 11, 2022 | Knicks | 114 | Jazz | 99 |
| February | 12, 2022 | Pistons | 85 | Knicks | 110 |
| February | 13, 2022 | Grizzlies | 98 | Knicks | 120 |
| February | 15, 2022 | Hornets | 73 | Knicks | 114 |
| February | 16, 2022 | Grizzlies | 101 | Knicks | 135 |
| February | 19, 2022 | Heat | 111 | Knicks | 99 |
| February | 22, 2022 | Cavaliers | 111 | Knicks | 106 |
| February | 25, 2022 | Knicks | 109 | Sonics | 126 |
| February | 26, 2022 | Pistons | 78 | Knicks | 115 |
| March | 1, 2022 | Grizzlies | 92 | Knicks | 103 |
| March | 2, 2022 | Heat | 143 | Knicks | 120 |
| March | 6, 2022 | Celtics | | Knicks | |
| March | 11, 2022 | Knicks | | Grizzlies | |
| March | 12, 2022 | Knicks | | Cavaliers | |
| March | 14, 2022 | Knicks | | Warriors | |
| March | 16, 2022 | Knicks | | Heat | |
| March | 17, 2022 | Knicks | | Hornets | |
| March | 18, 2022 | Bulls | | Knicks | |
| March | 19, 2022 | 76ers | | Knicks | |
| March | 20, 2022 | Knicks | | Heat | |
| March | 26, 2022 | Knicks | | Cavaliers | |
| March | 27, 2022 | Heat | | Knicks | |
| April | 1, 2022 | Knicks | | Pistons | |
| April | 2, 2022 | Knicks | | Hornets | |
| April | 3, 2022 | Cavaliers | | Knicks | |
| April | 4, 2022 | Knicks | | Bulls | |
| April | 5, 2022 | Knicks | | Bulls | |
| April | 6, 2022 | Knicks | | Celtics | |
| April | 10, 2022 | Bulls | | Knicks | |
| April | 11, 2022 | Grizzlies | | Knicks | |
| April | 12, 2022 | Knicks | | Raptors | |
| April | 13, 2022 | Knicks | | Bulls | |
| April | 14, 2022 | Lakers | | Knicks | |
| April | 15, 2022 | Knicks | | Pistons | |
| April | 17, 2022 | Timberwolves | | Knicks | |