| month | day | visitor | score | home | score |
|---|
| November | 2, 2021 | Grizzlies | 103 | Heat | 124 |
| November | 3, 2021 | Grizzlies | 102 | 76ers | 118 |
| November | 5, 2021 | Cavaliers | 111 | Grizzlies | 95 |
| November | 7, 2021 | Grizzlies | 112 | Raptors | 104 |
| November | 12, 2021 | Pistons | 103 | Grizzlies | 116 |
| November | 14, 2021 | Suns | 114 | Grizzlies | 103 |
| November | 15, 2021 | Jazz | 101 | Grizzlies | 93 |
| November | 18, 2021 | Hornets | 87 | Grizzlies | 96 |
| November | 21, 2021 | Spurs | 88 | Grizzlies | 111 |
| November | 22, 2021 | Knicks | 115 | Grizzlies | 117 |
| November | 23, 2021 | Grizzlies | 91 | Cavaliers | 95 |
| November | 25, 2021 | Grizzlies | 103 | Bulls | 106 |
| November | 26, 2021 | Grizzlies | 112 | 76ers | 122 |
| December | 2, 2021 | Grizzlies | 83 | Hornets | 81 |
| December | 3, 2021 | Grizzlies | 93 | Heat | 124 |
| December | 5, 2021 | Celtics | 120 | Grizzlies | 121 |
| December | 6, 2021 | Sonics | 96 | Grizzlies | 93 |
| December | 7, 2021 | Knicks | 102 | Grizzlies | 111 |
| December | 8, 2021 | Lakers | 99 | Grizzlies | 136 |
| December | 11, 2021 | Nuggets | 107 | Grizzlies | 104 |
| December | 17, 2021 | Cavaliers | 87 | Grizzlies | 102 |
| December | 18, 2021 | Bulls | 110 | Grizzlies | 84 |
| December | 19, 2021 | Warriors | 92 | Grizzlies | 110 |
| December | 20, 2021 | Grizzlies | 89 | Rockets | 92 |
| December | 21, 2021 | Pistons | 84 | Grizzlies | 114 |
| December | 28, 2021 | Grizzlies | 89 | Hornets | 88 |
| December | 29, 2021 | Cavaliers | 97 | Grizzlies | 93 |
| December | 30, 2021 | Hornets | 75 | Grizzlies | 79 |
| December | 31, 2021 | Bulls | 105 | Grizzlies | 93 |
| January | 1, 2022 | Grizzlies | 106 | Nuggets | 109 |
| January | 2, 2022 | Pistons | 108 | Grizzlies | 99 |
| January | 4, 2022 | Grizzlies | 106 | Celtics | 118 |
| January | 5, 2022 | Grizzlies | 115 | Pistons | 108 |
| January | 10, 2022 | Grizzlies | 103 | Celtics | 114 |
| January | 12, 2022 | Grizzlies | 112 | Warriors | 118 |
| January | 16, 2022 | Celtics | 111 | Grizzlies | 107 |
| January | 17, 2022 | Grizzlies | 81 | Hornets | 108 |
| January | 18, 2022 | Grizzlies | 99 | Raptors | 119 |
| January | 20, 2022 | Grizzlies | 105 | Pistons | 94 |
| January | 22, 2022 | Grizzlies | 89 | Bulls | 91 |
| January | 24, 2022 | Grizzlies | 98 | Heat | 139 |
| February | 8, 2022 | Celtics | 102 | Grizzlies | 105 |
| February | 12, 2022 | Grizzlies | 95 | Spurs | 93 |
| February | 13, 2022 | Grizzlies | 98 | Knicks | 120 |
| February | 16, 2022 | Grizzlies | 101 | Knicks | 135 |
| February | 17, 2022 | Bulls | 82 | Grizzlies | 81 |
| February | 19, 2022 | Pistons | 94 | Grizzlies | 102 |
| February | 20, 2022 | Raptors | 101 | Grizzlies | 92 |
| February | 24, 2022 | Heat | 130 | Grizzlies | 94 |
| February | 25, 2022 | Raptors | 105 | Grizzlies | 94 |
| February | 27, 2022 | Clippers | 103 | Grizzlies | 111 |
| February | 28, 2022 | Bulls | 79 | Grizzlies | 91 |
| March | 1, 2022 | Grizzlies | 92 | Knicks | 103 |
| March | 2, 2022 | Grizzlies | 93 | Celtics | 125 |
| March | 5, 2022 | Cavaliers | 101 | Grizzlies | 95 |
| March | 6, 2022 | Grizzlies | 95 | Jazz | 77 |
| March | 8, 2022 | Grizzlies | 88 | Hornets | 78 |
| March | 10, 2022 | Grizzlies | 73 | Pistons | 88 |
| March | 11, 2022 | Knicks | 103 | Grizzlies | 97 |
| March | 12, 2022 | 76ers | 116 | Grizzlies | 119 |
| March | 13, 2022 | Grizzlies | 87 | Suns | 103 |
| March | 14, 2022 | Grizzlies | 100 | Cavaliers | 102 |
| March | 15, 2022 | Heat | 103 | Grizzlies | 88 |
| March | 17, 2022 | Grizzlies | 110 | Cavaliers | 78 |
| March | 19, 2022 | Grizzlies | 71 | Bulls | 83 |
| March | 21, 2022 | Raptors | | Grizzlies | |
| March | 22, 2022 | Grizzlies | | 76ers | |
| March | 23, 2022 | Grizzlies | | Timberwolves | |
| March | 24, 2022 | Grizzlies | | Lakers | |
| March | 25, 2022 | Hornets | | Grizzlies | |
| March | 27, 2022 | Grizzlies | | Raptors | |
| March | 28, 2022 | Rockets | | Grizzlies | |
| March | 29, 2022 | Timberwolves | | Grizzlies | |
| March | 30, 2022 | Grizzlies | | Clippers | |
| April | 2, 2022 | Raptors | | Grizzlies | |
| April | 4, 2022 | 76ers | | Grizzlies | |
| April | 6, 2022 | Grizzlies | | Sonics | |
| April | 10, 2022 | Grizzlies | | Pistons | |
| April | 11, 2022 | Grizzlies | | Knicks | |
| April | 14, 2022 | 76ers | | Grizzlies | |
| April | 16, 2022 | Heat | | Grizzlies | |
| April | 20, 2022 | Grizzlies | | Bulls | |