| month | day | visitor | score | home | score |
|---|
| November | 3, 2021 | Pistons | 109 | Raptors | 85 |
| November | 4, 2021 | Pistons | 117 | Raptors | 95 |
| November | 7, 2021 | Grizzlies | 112 | Raptors | 104 |
| November | 8, 2021 | Knicks | 119 | Raptors | 109 |
| November | 9, 2021 | Heat | 116 | Raptors | 98 |
| November | 12, 2021 | Knicks | 118 | Raptors | 103 |
| November | 13, 2021 | Raptors | 103 | Warriors | 120 |
| November | 15, 2021 | Raptors | 112 | Cavaliers | 107 |
| November | 17, 2021 | Raptors | 116 | Cavaliers | 105 |
| November | 19, 2021 | Raptors | 112 | Clippers | 94 |
| November | 20, 2021 | Warriors | 127 | Raptors | 104 |
| November | 22, 2021 | Bulls | 74 | Raptors | 108 |
| November | 23, 2021 | Raptors | 123 | 76ers | 106 |
| November | 26, 2021 | Raptors | 99 | Pistons | 117 |
| November | 27, 2021 | Lakers | 115 | Raptors | 112 |
| November | 29, 2021 | Raptors | 119 | Celtics | 108 |
| December | 1, 2021 | Raptors | 108 | Pistons | 118 |
| December | 2, 2021 | Cavaliers | 120 | Raptors | 101 |
| December | 3, 2021 | Celtics | 104 | Raptors | 107 |
| December | 7, 2021 | Cavaliers | 76 | Raptors | 102 |
| December | 9, 2021 | Raptors | 97 | Pistons | 114 |
| December | 11, 2021 | Raptors | 126 | 76ers | 123 |
| December | 13, 2021 | Bulls | 113 | Raptors | 107 |
| December | 15, 2021 | Raptors | 90 | Hornets | 88 |
| December | 21, 2021 | Raptors | 105 | Knicks | 108 |
| December | 23, 2021 | Hornets | 75 | Raptors | 85 |
| December | 26, 2021 | Raptors | 118 | Knicks | 116 |
| December | 28, 2021 | Raptors | 102 | Bulls | 130 |
| December | 30, 2021 | Nuggets | 100 | Raptors | 114 |
| January | 3, 2022 | Celtics | 111 | Raptors | 107 |
| January | 5, 2022 | Raptors | 98 | Heat | 131 |
| January | 6, 2022 | Raptors | 107 | Knicks | 128 |
| January | 7, 2022 | Pistons | 128 | Raptors | 121 |
| January | 9, 2022 | Heat | 126 | Raptors | 106 |
| January | 10, 2022 | Jazz | 100 | Raptors | 108 |
| January | 11, 2022 | Raptors | 132 | Nuggets | 110 |
| January | 12, 2022 | 76ers | 113 | Raptors | 104 |
| January | 17, 2022 | Raptors | 95 | Pistons | 113 |
| January | 18, 2022 | Grizzlies | 99 | Raptors | 119 |
| January | 19, 2022 | Raptors | 100 | Spurs | 88 |
| January | 20, 2022 | Raptors | 112 | Rockets | 119 |
| January | 23, 2022 | Heat | 120 | Raptors | 97 |
| January | 25, 2022 | Raptors | 105 | Jazz | 99 |
| January | 28, 2022 | Raptors | 101 | Heat | 129 |
| February | 5, 2022 | Knicks | 103 | Raptors | 135 |
| February | 10, 2022 | Cavaliers | 106 | Raptors | 97 |
| February | 13, 2022 | Raptors | 94 | Bulls | 104 |
| February | 14, 2022 | Raptors | 118 | Celtics | 107 |
| February | 16, 2022 | Raptors | 136 | Celtics | 131 |
| February | 19, 2022 | Raptors | 99 | Celtics | 109 |
| February | 20, 2022 | Raptors | 101 | Grizzlies | 92 |
| February | 23, 2022 | Raptors | 95 | Hornets | 89 |
| February | 24, 2022 | Timberwolves | 96 | Raptors | 119 |
| February | 25, 2022 | Raptors | 105 | Grizzlies | 94 |
| February | 26, 2022 | 76ers | 112 | Raptors | 116 |
| March | 1, 2022 | Hornets | 93 | Raptors | 85 |
| March | 3, 2022 | Celtics | 118 | Raptors | 106 |
| March | 4, 2022 | 76ers | 96 | Raptors | 102 |
| March | 5, 2022 | Raptors | 109 | Heat | 130 |
| March | 7, 2022 | Raptors | | Cavaliers | |
| March | 16, 2022 | Hornets | | Raptors | |
| March | 17, 2022 | Raptors | | Lakers | |
| March | 18, 2022 | Raptors | | 76ers | |
| March | 20, 2022 | Spurs | | Raptors | |
| March | 21, 2022 | Raptors | | Grizzlies | |
| March | 23, 2022 | Raptors | | Bulls | |
| March | 25, 2022 | Bulls | | Raptors | |
| March | 26, 2022 | Hornets | | Raptors | |
| March | 27, 2022 | Grizzlies | | Raptors | |
| March | 29, 2022 | Suns | | Raptors | |
| March | 31, 2022 | Sonics | | Raptors | |
| April | 2, 2022 | Raptors | | Grizzlies | |
| April | 3, 2022 | Raptors | | Timberwolves | |
| April | 4, 2022 | Clippers | | Raptors | |
| April | 5, 2022 | Rockets | | Raptors | |
| April | 6, 2022 | Cavaliers | | Raptors | |
| April | 7, 2022 | Bulls | | Raptors | |
| April | 10, 2022 | Raptors | | Heat | |
| April | 12, 2022 | Knicks | | Raptors | |
| April | 13, 2022 | Raptors | | Suns | |
| April | 18, 2022 | Raptors | | 76ers | |
| April | 19, 2022 | Raptors | | Sonics | |