| month | day | visitor | score | home | score |
|---|
| November | 4, 2021 | Clippers | 116 | Timberwolves | 125 |
| November | 5, 2021 | Celtics | 111 | Clippers | 123 |
| November | 6, 2021 | Clippers | 106 | Hornets | 70 |
| November | 11, 2021 | Rockets | 86 | Clippers | 104 |
| November | 12, 2021 | Clippers | 90 | Lakers | 102 |
| November | 15, 2021 | Sonics | 96 | Clippers | 100 |
| November | 16, 2021 | Nuggets | 95 | Clippers | 114 |
| November | 17, 2021 | Clippers | 94 | Sonics | 113 |
| November | 19, 2021 | Raptors | 112 | Clippers | 94 |
| November | 22, 2021 | Clippers | 83 | Rockets | 106 |
| November | 26, 2021 | Clippers | 99 | Suns | 65 |
| November | 27, 2021 | Clippers | 112 | Timberwolves | 120 |
| November | 30, 2021 | Clippers | 102 | Timberwolves | 116 |
| December | 1, 2021 | Clippers | 98 | Bulls | 91 |
| December | 3, 2021 | Clippers | 85 | Knicks | 111 |
| December | 4, 2021 | Nuggets | 97 | Clippers | 100 |
| December | 9, 2021 | Clippers | 109 | Warriors | 111 |
| December | 12, 2021 | Clippers | 108 | Warriors | 122 |
| December | 13, 2021 | Clippers | 100 | Lakers | 123 |
| December | 16, 2021 | Timberwolves | 102 | Clippers | 93 |
| December | 23, 2021 | Jazz | 92 | Clippers | 100 |
| December | 25, 2021 | Spurs | 90 | Clippers | 100 |
| December | 28, 2021 | Lakers | 90 | Clippers | 105 |
| December | 30, 2021 | Clippers | 113 | Spurs | 106 |
| January | 4, 2022 | Clippers | 96 | Lakers | 108 |
| January | 5, 2022 | Suns | 104 | Clippers | 101 |
| January | 6, 2022 | Sonics | 100 | Clippers | 99 |
| January | 7, 2022 | Suns | 88 | Clippers | 91 |
| January | 8, 2022 | Spurs | 89 | Clippers | 95 |
| January | 9, 2022 | Clippers | 113 | Nuggets | 116 |
| January | 10, 2022 | Knicks | 93 | Clippers | 96 |
| January | 12, 2022 | Timberwolves | 84 | Clippers | 117 |
| January | 13, 2022 | Clippers | 99 | Lakers | 100 |
| January | 14, 2022 | Bulls | 109 | Clippers | 88 |
| January | 15, 2022 | Pistons | 95 | Clippers | 111 |
| January | 17, 2022 | Clippers | 105 | Cavaliers | 92 |
| January | 19, 2022 | Clippers | 106 | Warriors | 124 |
| January | 20, 2022 | Clippers | 121 | Suns | 91 |
| January | 21, 2022 | Sonics | 106 | Clippers | 113 |
| January | 22, 2022 | Jazz | 88 | Clippers | 97 |
| January | 27, 2022 | Clippers | 108 | Rockets | 104 |
| January | 28, 2022 | Clippers | 88 | Warriors | 124 |
| January | 29, 2022 | Jazz | 74 | Clippers | 101 |
| February | 6, 2022 | Clippers | 98 | Jazz | 88 |
| February | 7, 2022 | Clippers | 94 | Timberwolves | 100 |
| February | 8, 2022 | Warriors | 97 | Clippers | 98 |
| February | 11, 2022 | Warriors | 112 | Clippers | 121 |
| February | 13, 2022 | Clippers | 117 | Lakers | 84 |
| February | 14, 2022 | Rockets | 108 | Clippers | 116 |
| February | 15, 2022 | Clippers | 109 | Jazz | 90 |
| February | 17, 2022 | Hornets | 77 | Clippers | 95 |
| February | 18, 2022 | Jazz | 79 | Clippers | 102 |
| February | 21, 2022 | Clippers | 96 | Sonics | 115 |
| February | 22, 2022 | Clippers | 96 | Suns | 118 |
| February | 25, 2022 | Suns | 97 | Clippers | 108 |
| February | 26, 2022 | Clippers | 88 | Sonics | 91 |
| February | 27, 2022 | Clippers | 103 | Grizzlies | 111 |
| February | 28, 2022 | Clippers | 93 | Rockets | 103 |
| March | 4, 2022 | Clippers | 98 | Rockets | 107 |
| March | 5, 2022 | Clippers | 84 | Spurs | 81 |
| March | 8, 2022 | Nuggets | 94 | Clippers | 90 |
| March | 9, 2022 | Warriors | 128 | Clippers | 99 |
| March | 10, 2022 | Heat | 112 | Clippers | 104 |
| March | 13, 2022 | Warriors | 83 | Clippers | 112 |
| March | 17, 2022 | Clippers | 95 | Heat | 106 |
| March | 20, 2022 | Rockets | 122 | Clippers | 115 |
| March | 24, 2022 | Clippers | | Nuggets | |
| March | 27, 2022 | Clippers | | Suns | |
| March | 28, 2022 | Suns | | Clippers | |
| March | 30, 2022 | Grizzlies | | Clippers | |
| April | 4, 2022 | Clippers | | Raptors | |
| April | 7, 2022 | Clippers | | Sonics | |
| April | 8, 2022 | Spurs | | Clippers | |
| April | 9, 2022 | Timberwolves | | Clippers | |
| April | 10, 2022 | Clippers | | 76ers | |
| April | 11, 2022 | Spurs | | Clippers | |
| April | 13, 2022 | Lakers | | Clippers | |
| April | 14, 2022 | Cavaliers | | Clippers | |
| April | 15, 2022 | 76ers | | Clippers | |
| April | 16, 2022 | Nuggets | | Clippers | |
| April | 18, 2022 | Clippers | | Pistons | |
| April | 19, 2022 | Clippers | | Celtics | |