| month | day | visitor | score | home | score |
|---|
| November | 4, 2020 | Knicks | 114 | Spurs | 107 |
| November | 5, 2020 | Spurs | 119 | Heat | 97 |
| November | 10, 2020 | Spurs | 99 | Wolves | 117 |
| November | 13, 2020 | Lakers | 126 | Spurs | 90 |
| November | 15, 2020 | Rockets | 104 | Spurs | 114 |
| November | 18, 2020 | Spurs | 76 | Mavericks | 84 |
| November | 19, 2020 | Grizzlies | 113 | Spurs | 111 |
| November | 22, 2020 | Jazz | 99 | Spurs | 106 |
| November | 27, 2020 | Jazz | 81 | Spurs | 126 |
| November | 29, 2020 | Suns | 115 | Spurs | 124 |
| December | 5, 2020 | Jazz | 111 | Spurs | 100 |
| December | 6, 2020 | Spurs | 102 | Clippers | 101 |
| December | 7, 2020 | Bucks | 98 | Spurs | 101 |
| December | 8, 2020 | Wolves | 121 | Spurs | 131 |
| December | 10, 2020 | Nuggets | 103 | Spurs | 109 |
| December | 11, 2020 | Warriors | 98 | Spurs | 109 |
| December | 13, 2020 | Hawks | 108 | Spurs | 103 |
| December | 15, 2020 | Spurs | 94 | Celtics | 119 |
| December | 17, 2020 | Spurs | 104 | Rockets | 113 |
| December | 20, 2020 | Spurs | 85 | Mavericks | 104 |
| December | 21, 2020 | Spurs | 101 | Pelicans | 125 |
| December | 22, 2020 | Mavericks | 94 | Spurs | 92 |
| December | 23, 2020 | Pacers | 101 | Spurs | 89 |
| December | 31, 2020 | Kings | 103 | Spurs | 106 |
| January | 1, 2021 | Blazers | 133 | Spurs | 130 |
| January | 2, 2021 | Nets | 108 | Spurs | 126 |
| January | 3, 2021 | Spurs | 104 | Kings | 87 |
| January | 5, 2021 | Lakers | 126 | Spurs | 107 |
| January | 7, 2021 | Spurs | 98 | Sonics | 84 |
| January | 8, 2021 | Sonics | 116 | Spurs | 106 |
| January | 9, 2021 | Spurs | 93 | Clippers | 107 |
| January | 11, 2021 | Clippers | 116 | Spurs | 124 |
| January | 14, 2021 | Spurs | 132 | Wolves | 116 |
| January | 17, 2021 | Spurs | 93 | Mavericks | 88 |
| January | 20, 2021 | Mavericks | 94 | Spurs | 99 |
| January | 21, 2021 | Clippers | 95 | Spurs | 99 |
| January | 25, 2021 | Spurs | 99 | Bulls | 103 |
| January | 27, 2021 | Spurs | 107 | Jazz | 111 |
| January | 28, 2021 | Blazers | 124 | Spurs | 134 |
| January | 29, 2021 | Spurs | 107 | Bucks | 118 |
| February | 1, 2021 | Kings | 87 | Spurs | 108 |
| February | 2, 2021 | Spurs | 122 | Nuggets | 126 |
| February | 4, 2021 | Heat | 88 | Spurs | 100 |
| February | 9, 2021 | Spurs | 95 | Jazz | 101 |
| February | 11, 2021 | Pelicans | 106 | Spurs | 107 |
| February | 12, 2021 | Warriors | 96 | Spurs | 88 |
| February | 13, 2021 | Spurs | 103 | Kings | 102 |
| February | 15, 2021 | Spurs | 102 | Rockets | 115 |
| February | 16, 2021 | Bulls | 120 | Spurs | 112 |
| February | 21, 2021 | Spurs | 109 | Nuggets | 134 |
| February | 24, 2021 | Wolves | 131 | Spurs | 130 |
| February | 26, 2021 | Spurs | 116 | Hawks | 99 |
| February | 28, 2021 | 76ers | 106 | Spurs | 96 |
| March | 2, 2021 | Spurs | 99 | Knicks | 105 |
| March | 3, 2021 | Spurs | 93 | Sonics | 102 |
| March | 4, 2021 | Spurs | 101 | Nuggets | 116 |
| March | 6, 2021 | Rockets | 109 | Spurs | 100 |
| March | 8, 2021 | Spurs | 129 | Suns | 96 |
| March | 9, 2021 | Spurs | 87 | Lakers | 116 |
| March | 11, 2021 | Sonics | 115 | Spurs | 97 |
| March | 12, 2021 | Spurs | 99 | Lakers | 114 |
| March | 15, 2021 | Mavericks | 111 | Spurs | 109 |
| March | 21, 2021 | Celtics | 135 | Spurs | 112 |
| March | 23, 2021 | Spurs | 110 | Warriors | 97 |
| March | 27, 2021 | Spurs | 99 | Nets | 108 |
| March | 29, 2021 | Spurs | 104 | Grizzlies | 80 |
| March | 30, 2021 | Spurs | 102 | Suns | 110 |
| April | 1, 2021 | Rockets | 97 | Spurs | 101 |
| April | 3, 2021 | Spurs | 89 | Wolves | 117 |
| April | 4, 2021 | Raptors | 121 | Spurs | 103 |
| April | 7, 2021 | Suns | 99 | Spurs | 104 |
| April | 8, 2021 | Spurs | 107 | 76ers | 108 |
| April | 9, 2021 | Spurs | 109 | Warriors | 107 |
| April | 10, 2021 | Nuggets | 128 | Spurs | 121 |
| April | 11, 2021 | Spurs | 113 | Blazers | 117 |
| April | 12, 2021 | Spurs | 117 | Jazz | 95 |
| April | 13, 2021 | Wolves | 105 | Spurs | 111 |
| April | 14, 2021 | Spurs | 109 | Raptors | 128 |
| April | 16, 2021 | Spurs | 109 | Suns | 119 |
| April | 22, 2021 | Spurs | 114 | Blazers | 123 |
| April | 24, 2021 | Spurs | 110 | Pacers | 102 |
| April | 25, 2021 | Nuggets | 114 | Spurs | 127 |
| Post | 1, 2021 | Spurs | 108 | Rockets | 122 |
| Post | 2, 2021 | Spurs | 110 | Rockets | 130 |
| Post | 3, 2021 | Rockets | 112 | Spurs | 129 |
| Post | 4, 2021 | Rockets | 124 | Spurs | 105 |
| Post | 5, 2021 | Spurs | 96 | Rockets | 109 |
| Post | 6, 2021 | Rockets | | Spurs | |
| Post | 7, 2021 | Spurs | | Rockets | |