| month | day | visitor | score | home | score |
|---|
| November | 2, 2021 | Grizzlies | 103 | Heat | 124 |
| November | 4, 2021 | Heat | 117 | Celtics | 97 |
| November | 7, 2021 | Heat | 98 | Bulls | 111 |
| November | 8, 2021 | Heat | 127 | Lakers | 93 |
| November | 9, 2021 | Heat | 116 | Raptors | 98 |
| November | 14, 2021 | Celtics | 109 | Heat | 127 |
| November | 15, 2021 | Nuggets | 106 | Heat | 127 |
| November | 16, 2021 | Heat | 107 | Bulls | 103 |
| November | 17, 2021 | Heat | 114 | Knicks | 105 |
| November | 20, 2021 | Heat | 101 | Suns | 74 |
| November | 23, 2021 | Pistons | 76 | Heat | 132 |
| November | 24, 2021 | Pistons | 87 | Heat | 105 |
| November | 28, 2021 | Heat | 129 | Knicks | 107 |
| December | 1, 2021 | Cavaliers | 98 | Heat | 116 |
| December | 3, 2021 | Grizzlies | 93 | Heat | 124 |
| December | 4, 2021 | Heat | 125 | Cavaliers | 89 |
| December | 7, 2021 | Heat | 103 | Pistons | 112 |
| December | 9, 2021 | Heat | 124 | Cavaliers | 112 |
| December | 13, 2021 | Hornets | 75 | Heat | 108 |
| December | 20, 2021 | Bulls | 95 | Heat | 111 |
| December | 21, 2021 | Timberwolves | 97 | Heat | 144 |
| December | 22, 2021 | Heat | 131 | Celtics | 123 |
| December | 23, 2021 | Rockets | 113 | Heat | 115 |
| December | 25, 2021 | Celtics | 100 | Heat | 133 |
| December | 27, 2021 | Cavaliers | 95 | Heat | 131 |
| December | 28, 2021 | Heat | 103 | Warriors | 110 |
| December | 29, 2021 | Heat | 108 | Hornets | 71 |
| December | 30, 2021 | Heat | 108 | Bulls | 106 |
| January | 1, 2022 | 76ers | 105 | Heat | 116 |
| January | 3, 2022 | Pistons | 101 | Heat | 123 |
| January | 5, 2022 | Raptors | 98 | Heat | 131 |
| January | 9, 2022 | Heat | 126 | Raptors | 106 |
| January | 11, 2022 | Heat | 98 | Spurs | 89 |
| January | 13, 2022 | Heat | 97 | Pistons | 95 |
| January | 18, 2022 | Sonics | 110 | Heat | 111 |
| January | 22, 2022 | Cavaliers | 89 | Heat | 128 |
| January | 23, 2022 | Heat | 120 | Raptors | 97 |
| January | 24, 2022 | Grizzlies | 98 | Heat | 139 |
| January | 25, 2022 | Celtics | 115 | Heat | 120 |
| January | 26, 2022 | Celtics | 129 | Heat | 126 |
| January | 27, 2022 | Heat | 106 | Hornets | 80 |
| January | 28, 2022 | Raptors | 101 | Heat | 129 |
| January | 29, 2022 | 76ers | 93 | Heat | 118 |
| February | 6, 2022 | Heat | 117 | Sonics | 106 |
| February | 13, 2022 | Hornets | 90 | Heat | 109 |
| February | 19, 2022 | Heat | 111 | Knicks | 99 |
| February | 20, 2022 | Jazz | 66 | Heat | 122 |
| February | 21, 2022 | 76ers | 93 | Heat | 123 |
| February | 22, 2022 | Warriors | 88 | Heat | 120 |
| February | 24, 2022 | Heat | 130 | Grizzlies | 94 |
| February | 27, 2022 | Lakers | 94 | Heat | 119 |
| March | 1, 2022 | Heat | 122 | Cavaliers | 79 |
| March | 2, 2022 | Heat | 143 | Knicks | 120 |
| March | 4, 2022 | Spurs | 111 | Heat | 125 |
| March | 5, 2022 | Raptors | 109 | Heat | 130 |
| March | 6, 2022 | Heat | 139 | 76ers | 129 |
| March | 7, 2022 | Celtics | 105 | Heat | 120 |
| March | 10, 2022 | Heat | 112 | Clippers | 104 |
| March | 13, 2022 | Heat | 112 | Rockets | 106 |
| March | 15, 2022 | Heat | 103 | Grizzlies | 88 |
| March | 16, 2022 | Knicks | 108 | Heat | 123 |
| March | 17, 2022 | Clippers | 95 | Heat | 106 |
| March | 18, 2022 | Heat | 121 | Jazz | 88 |
| March | 20, 2022 | Knicks | 90 | Heat | 118 |
| March | 21, 2022 | Cavaliers | | Heat | |
| March | 23, 2022 | Heat | | Pistons | |
| March | 26, 2022 | Pistons | | Heat | |
| March | 27, 2022 | Heat | | Knicks | |
| March | 28, 2022 | Heat | | Timberwolves | |
| April | 2, 2022 | Heat | | 76ers | |
| April | 4, 2022 | Hornets | | Heat | |
| April | 5, 2022 | Heat | | Hornets | |
| April | 6, 2022 | 76ers | | Heat | |
| April | 9, 2022 | Heat | | Bulls | |
| April | 10, 2022 | Raptors | | Heat | |
| April | 12, 2022 | Heat | | Hornets | |
| April | 14, 2022 | Bulls | | Heat | |
| April | 15, 2022 | Heat | | Nuggets | |
| April | 16, 2022 | Heat | | Grizzlies | |
| April | 17, 2022 | Heat | | 76ers | |
| April | 18, 2022 | Suns | | Heat | |
| April | 20, 2022 | Heat | | Hornets | |