| month | day | visitor | score | home | score |
|---|
| November | 4, 2021 | Bulls | 89 | Cavaliers | 80 |
| November | 5, 2021 | Bulls | 108 | 76ers | 111 |
| November | 6, 2021 | Bulls | 104 | Sonics | 81 |
| November | 7, 2021 | Heat | 98 | Bulls | 111 |
| November | 8, 2021 | Jazz | 82 | Bulls | 84 |
| November | 10, 2021 | Pistons | 78 | Bulls | 81 |
| November | 11, 2021 | Bulls | 84 | Pistons | 59 |
| November | 14, 2021 | Bulls | 92 | Lakers | 103 |
| November | 16, 2021 | Heat | 107 | Bulls | 103 |
| November | 17, 2021 | 76ers | 100 | Bulls | 103 |
| November | 18, 2021 | Bulls | 102 | Celtics | 98 |
| November | 19, 2021 | Celtics | 100 | Bulls | 109 |
| November | 21, 2021 | Hornets | 91 | Bulls | 87 |
| November | 22, 2021 | Bulls | 74 | Raptors | 108 |
| November | 23, 2021 | Hornets | 78 | Bulls | 83 |
| November | 24, 2021 | Bulls | 112 | Nuggets | 98 |
| November | 25, 2021 | Grizzlies | 103 | Bulls | 106 |
| November | 28, 2021 | Sonics | 105 | Bulls | 93 |
| December | 1, 2021 | Clippers | 98 | Bulls | 91 |
| December | 7, 2021 | Hornets | 83 | Bulls | 112 |
| December | 8, 2021 | Bulls | 76 | Cavaliers | 73 |
| December | 12, 2021 | Cavaliers | 70 | Bulls | 68 |
| December | 13, 2021 | Bulls | 113 | Raptors | 107 |
| December | 15, 2021 | 76ers | 98 | Bulls | 114 |
| December | 16, 2021 | Nuggets | 98 | Bulls | 102 |
| December | 17, 2021 | Timberwolves | 93 | Bulls | 95 |
| December | 18, 2021 | Bulls | 110 | Grizzlies | 84 |
| December | 19, 2021 | Bulls | 106 | Celtics | 108 |
| December | 20, 2021 | Bulls | 95 | Heat | 111 |
| December | 23, 2021 | Bulls | 87 | Cavaliers | 99 |
| December | 24, 2021 | Bulls | 117 | Rockets | 97 |
| December | 25, 2021 | Bulls | 108 | Pistons | 85 |
| December | 26, 2021 | Bulls | 101 | Cavaliers | 80 |
| December | 27, 2021 | Pistons | 73 | Bulls | 101 |
| December | 28, 2021 | Raptors | 102 | Bulls | 130 |
| December | 30, 2021 | Heat | 108 | Bulls | 106 |
| December | 31, 2021 | Bulls | 105 | Grizzlies | 93 |
| January | 2, 2022 | Bulls | 99 | Suns | 127 |
| January | 4, 2022 | Warriors | 115 | Bulls | 112 |
| January | 5, 2022 | Cavaliers | 78 | Bulls | 104 |
| January | 7, 2022 | Bulls | 91 | Hornets | 86 |
| January | 14, 2022 | Bulls | 109 | Clippers | 88 |
| January | 15, 2022 | Bulls | 126 | 76ers | 135 |
| January | 16, 2022 | Knicks | 78 | Bulls | 91 |
| January | 20, 2022 | Bulls | 126 | Warriors | 110 |
| January | 22, 2022 | Grizzlies | 89 | Bulls | 91 |
| January | 26, 2022 | Bulls | 104 | Hornets | 78 |
| February | 9, 2022 | Bulls | 91 | Pistons | 76 |
| February | 10, 2022 | Celtics | 95 | Bulls | 98 |
| February | 13, 2022 | Raptors | 94 | Bulls | 104 |
| February | 14, 2022 | Bulls | 93 | Timberwolves | 81 |
| February | 15, 2022 | Bulls | 81 | 76ers | 107 |
| February | 17, 2022 | Bulls | 82 | Grizzlies | 81 |
| February | 18, 2022 | Bulls | 96 | Spurs | 86 |
| February | 25, 2022 | Bulls | 87 | Celtics | 102 |
| February | 27, 2022 | Bulls | 94 | Pistons | 69 |
| February | 28, 2022 | Bulls | 79 | Grizzlies | 91 |
| March | 2, 2022 | Bulls | 95 | 76ers | 127 |
| March | 3, 2022 | Hornets | 75 | Bulls | 98 |
| March | 12, 2022 | Celtics | | Bulls | |
| March | 13, 2022 | Lakers | | Bulls | |
| March | 15, 2022 | Bulls | | Jazz | |
| March | 16, 2022 | 76ers | | Bulls | |
| March | 18, 2022 | Bulls | | Knicks | |
| March | 19, 2022 | Grizzlies | | Bulls | |
| March | 23, 2022 | Raptors | | Bulls | |
| March | 24, 2022 | Spurs | | Bulls | |
| March | 25, 2022 | Bulls | | Raptors | |
| March | 28, 2022 | Pistons | | Bulls | |
| March | 30, 2022 | Pistons | | Bulls | |
| April | 4, 2022 | Knicks | | Bulls | |
| April | 5, 2022 | Knicks | | Bulls | |
| April | 7, 2022 | Bulls | | Raptors | |
| April | 9, 2022 | Heat | | Bulls | |
| April | 10, 2022 | Bulls | | Knicks | |
| April | 11, 2022 | Bulls | | Celtics | |
| April | 12, 2022 | Rockets | | Bulls | |
| April | 13, 2022 | Knicks | | Bulls | |
| April | 14, 2022 | Bulls | | Heat | |
| April | 17, 2022 | Suns | | Bulls | |
| April | 19, 2022 | Bulls | | Cavaliers | |
| April | 20, 2022 | Grizzlies | | Bulls | |