| month | day | visitor | score | home | score |
|---|
| November | 3, 2021 | Grizzlies | 102 | 76ers | 118 |
| November | 4, 2021 | 76ers | 101 | Lakers | 105 |
| November | 5, 2021 | Bulls | 108 | 76ers | 111 |
| November | 7, 2021 | Suns | 84 | 76ers | 128 |
| November | 15, 2021 | Pistons | 110 | 76ers | 115 |
| November | 17, 2021 | 76ers | 100 | Bulls | 103 |
| November | 21, 2021 | 76ers | 142 | Warriors | 141 |
| November | 23, 2021 | Raptors | 123 | 76ers | 106 |
| November | 25, 2021 | Cavaliers | 94 | 76ers | 116 |
| November | 26, 2021 | Grizzlies | 112 | 76ers | 122 |
| November | 27, 2021 | Sonics | 118 | 76ers | 109 |
| November | 30, 2021 | 76ers | 94 | Celtics | 128 |
| December | 2, 2021 | 76ers | 104 | Celtics | 117 |
| December | 5, 2021 | Knicks | 105 | 76ers | 128 |
| December | 6, 2021 | 76ers | 105 | Pistons | 116 |
| December | 8, 2021 | Pistons | 111 | 76ers | 117 |
| December | 9, 2021 | 76ers | 107 | Rockets | 100 |
| December | 10, 2021 | 76ers | 99 | Pistons | 105 |
| December | 11, 2021 | Raptors | 126 | 76ers | 123 |
| December | 15, 2021 | 76ers | 98 | Bulls | 114 |
| December | 18, 2021 | 76ers | 114 | Spurs | 109 |
| December | 20, 2021 | 76ers | 105 | Hornets | 116 |
| December | 22, 2021 | Cavaliers | 103 | 76ers | 127 |
| December | 24, 2021 | Knicks | 106 | 76ers | 109 |
| December | 28, 2021 | 76ers | 103 | Knicks | 104 |
| December | 29, 2021 | Knicks | 107 | 76ers | 95 |
| December | 31, 2021 | 76ers | 100 | Cavaliers | 117 |
| January | 1, 2022 | 76ers | 105 | Heat | 116 |
| January | 4, 2022 | 76ers | 118 | Knicks | 116 |
| January | 8, 2022 | 76ers | 115 | Cavaliers | 98 |
| January | 12, 2022 | 76ers | 113 | Raptors | 104 |
| January | 14, 2022 | Lakers | 97 | 76ers | 120 |
| January | 15, 2022 | Bulls | 126 | 76ers | 135 |
| January | 18, 2022 | Jazz | 98 | 76ers | 107 |
| January | 19, 2022 | 76ers | 129 | Knicks | 113 |
| January | 22, 2022 | 76ers | 108 | Celtics | 95 |
| January | 24, 2022 | Spurs | 96 | 76ers | 130 |
| January | 27, 2022 | Warriors | 110 | 76ers | 128 |
| January | 28, 2022 | Celtics | 106 | 76ers | 82 |
| January | 29, 2022 | 76ers | 93 | Heat | 118 |
| February | 5, 2022 | 76ers | 100 | Pistons | 92 |
| February | 6, 2022 | Hornets | 104 | 76ers | 102 |
| February | 8, 2022 | 76ers | 97 | Timberwolves | 116 |
| February | 11, 2022 | Celtics | 125 | 76ers | 117 |
| February | 13, 2022 | 76ers | 118 | Suns | 107 |
| February | 14, 2022 | Pistons | 102 | 76ers | 106 |
| February | 15, 2022 | Bulls | 81 | 76ers | 107 |
| February | 17, 2022 | 76ers | 102 | Nuggets | 101 |
| February | 20, 2022 | 76ers | 112 | Cavaliers | 96 |
| February | 21, 2022 | 76ers | 93 | Heat | 123 |
| February | 26, 2022 | 76ers | 112 | Raptors | 116 |
| February | 27, 2022 | Cavaliers | 90 | 76ers | 121 |
| March | 2, 2022 | Bulls | 95 | 76ers | 127 |
| March | 4, 2022 | 76ers | 96 | Raptors | 102 |
| March | 6, 2022 | Heat | 139 | 76ers | 129 |
| March | 7, 2022 | Timberwolves | 94 | 76ers | 119 |
| March | 9, 2022 | 76ers | 101 | Hornets | 113 |
| March | 11, 2022 | Hornets | 82 | 76ers | 108 |
| March | 12, 2022 | 76ers | 116 | Grizzlies | 119 |
| March | 14, 2022 | 76ers | 113 | Hornets | 109 |
| March | 16, 2022 | 76ers | 98 | Bulls | 109 |
| March | 18, 2022 | Raptors | 89 | 76ers | 126 |
| March | 19, 2022 | 76ers | 108 | Knicks | 139 |
| March | 22, 2022 | Grizzlies | | 76ers | |
| March | 23, 2022 | 76ers | | Sonics | |
| March | 24, 2022 | 76ers | | Jazz | |
| March | 26, 2022 | Celtics | | 76ers | |
| March | 31, 2022 | Cavaliers | | 76ers | |
| April | 2, 2022 | Heat | | 76ers | |
| April | 3, 2022 | Hornets | | 76ers | |
| April | 4, 2022 | 76ers | | Grizzlies | |
| April | 6, 2022 | 76ers | | Heat | |
| April | 7, 2022 | 76ers | | Celtics | |
| April | 8, 2022 | Nuggets | | 76ers | |
| April | 9, 2022 | Rockets | | 76ers | |
| April | 10, 2022 | Clippers | | 76ers | |
| April | 13, 2022 | Hornets | | 76ers | |
| April | 14, 2022 | 76ers | | Grizzlies | |
| April | 15, 2022 | 76ers | | Clippers | |
| April | 17, 2022 | Heat | | 76ers | |
| April | 18, 2022 | Raptors | | 76ers | |
| April | 19, 2022 | 76ers | | Hornets | |