| month | day | visitor | score | home | score |
|---|
| November | 2, 2021 | Kings | 109 | Grizzlies | 103 |
| November | 7, 2021 | Spurs | 91 | Grizzlies | 101 |
| November | 11, 2021 | Nuggets | 127 | Grizzlies | 99 |
| November | 15, 2021 | Nuggets | 144 | Grizzlies | 96 |
| November | 18, 2021 | Grizzlies | 67 | Lakers | 119 |
| November | 19, 2021 | Blazers | 104 | Grizzlies | 83 |
| November | 20, 2021 | Jazz | 122 | Grizzlies | 81 |
| November | 21, 2021 | Grizzlies | 111 | Nuggets | 114 |
| November | 24, 2021 | Grizzlies | 86 | Spurs | 95 |
| November | 26, 2021 | Suns | 103 | Grizzlies | 89 |
| November | 27, 2021 | Pelicans | 112 | Grizzlies | 103 |
| December | 2, 2021 | Warriors | 96 | Grizzlies | 89 |
| December | 3, 2021 | Grizzlies | 77 | Blazers | 119 |
| December | 5, 2021 | Grizzlies | 98 | Sonics | 112 |
| December | 6, 2021 | Grizzlies | 81 | Mavericks | 79 |
| December | 7, 2021 | Pelicans | 89 | Grizzlies | 115 |
| December | 13, 2021 | Grizzlies | 92 | Wolves | 100 |
| December | 14, 2021 | Wolves | 88 | Grizzlies | 97 |
| December | 18, 2021 | Grizzlies | 85 | Clippers | 139 |
| December | 19, 2021 | Clippers | 110 | Grizzlies | 113 |
| December | 21, 2021 | Grizzlies | 107 | Suns | 112 |
| December | 24, 2021 | Rockets | 97 | Grizzlies | 83 |
| December | 25, 2021 | Mavericks | 79 | Grizzlies | 84 |
| December | 26, 2021 | Lakers | 93 | Grizzlies | 84 |
| December | 27, 2021 | Grizzlies | 82 | Jazz | 98 |
| December | 29, 2021 | Grizzlies | 89 | Pelicans | 100 |
| December | 30, 2021 | Grizzlies | 91 | Jazz | 85 |
| December | 31, 2021 | Grizzlies | 94 | Mavericks | 89 |
| January | 4, 2022 | Grizzlies | 106 | Kings | 108 |
| January | 6, 2022 | Grizzlies | 75 | Rockets | 91 |
| January | 10, 2022 | Sonics | 100 | Grizzlies | 87 |
| January | 13, 2022 | Grizzlies | 68 | Warriors | 83 |