| month | day | visitor | score | home | score |
|---|
| November | 3, 2018 | Bobcats | 72 | Spurs | 89 |
| November | 4, 2018 | Blazers | 63 | Spurs | 80 |
| November | 5, 2018 | Spurs | 122 | Magic | 84 |
| November | 8, 2018 | Nets | 77 | Spurs | 79 |
| November | 9, 2018 | Wizards | 91 | Spurs | 74 |
| November | 10, 2018 | Spurs | 77 | Rockets | 81 |
| November | 12, 2018 | Spurs | 76 | Warriors | 59 |
| November | 15, 2018 | Hornets | 96 | Spurs | 105 |
| November | 17, 2018 | Rockets | 76 | Spurs | 88 |
| November | 18, 2018 | Spurs | 86 | Hornets | 85 |
| November | 19, 2018 | Grizzlies | 67 | Spurs | 88 |
| November | 20, 2018 | Spurs | 73 | Wizards | 74 |
| November | 24, 2018 | Spurs | 87 | Wolves | 80 |
| November | 25, 2018 | Wolves | 79 | Spurs | 101 |
| November | 28, 2018 | Heat | 84 | Spurs | 90 |
| November | 29, 2018 | Spurs | 87 | Jazz | 72 |
| December | 1, 2018 | Suns | 65 | Spurs | 79 |
| December | 5, 2018 | Spurs | 98 | Clippers | 93 |
| December | 6, 2018 | Spurs | 82 | Nets | 79 |
| December | 8, 2018 | Mavericks | 77 | Spurs | 80 |
| December | 9, 2018 | Spurs | 78 | Blazers | 99 |
| December | 14, 2018 | Spurs | 92 | Hawks | 88 |
| December | 16, 2018 | Spurs | 83 | Heat | 81 |
| December | 19, 2018 | Spurs | 88 | Pacers | 96 |
| December | 22, 2018 | Spurs | 76 | Bulls | 96 |
| December | 23, 2018 | Warriors | 63 | Spurs | 102 |
| December | 28, 2018 | Spurs | 77 | Suns | 76 |
| December | 29, 2018 | Magic | 97 | Spurs | 101 |
| January | 1, 2019 | Spurs | 84 | Sonics | 113 |
| January | 2, 2019 | Hawks | 58 | Spurs | 77 |
| January | 5, 2019 | Spurs | 88 | Bucks | 77 |
| January | 11, 2019 | Spurs | 83 | Clippers | 85 |
| January | 15, 2019 | Spurs | 85 | Kings | 93 |
| January | 19, 2019 | Sonics | 83 | Spurs | 93 |
| January | 20, 2019 | Clippers | 102 | Spurs | 99 |
| January | 24, 2019 | Spurs | 75 | Blazers | 89 |
| January | 25, 2019 | Sonics | 100 | Spurs | 81 |
| January | 27, 2019 | Spurs | 87 | Suns | 71 |
| January | 29, 2019 | Celtics | 78 | Spurs | 91 |
| January | 31, 2019 | Spurs | 79 | Knicks | 88 |
| February | 2, 2019 | Clippers | 92 | Spurs | 99 |
| February | 4, 2019 | Nuggets | 80 | Spurs | 83 |
| February | 5, 2019 | Kings | 80 | Spurs | 98 |
| February | 6, 2019 | Lakers | 74 | Spurs | 78 |
| February | 7, 2019 | Spurs | 64 | Celtics | 74 |
| February | 11, 2019 | Warriors | 46 | Spurs | 97 |
| February | 12, 2019 | Spurs | 81 | Nuggets | 109 |
| February | 13, 2019 | Spurs | 75 | Pistons | 79 |
| February | 14, 2019 | Spurs | 83 | Bobcats | 70 |
| February | 15, 2019 | Raptors | 64 | Spurs | 86 |
| February | 16, 2019 | Spurs | 94 | Lakers | 95 |
| February | 17, 2019 | Jazz | 79 | Spurs | 91 |
| February | 22, 2019 | Spurs | 103 | Hornets | 98 |
| February | 23, 2019 | Spurs | 92 | Kings | 72 |
| February | 25, 2019 | Spurs | 85 | Mavericks | 87 |
| February | 26, 2019 | Spurs | 77 | Sonics | 106 |
| February | 27, 2019 | Knicks | 72 | Spurs | 107 |
| February | 28, 2019 | Pacers | 85 | Spurs | 97 |
| March | 3, 2019 | Bucks | 77 | Spurs | 85 |
| March | 5, 2019 | Bulls | 96 | Spurs | 93 |
| March | 6, 2019 | Spurs | 62 | 76ers | 70 |
| March | 7, 2019 | Spurs | 76 | Grizzlies | 69 |
| March | 8, 2019 | Kings | 83 | Spurs | 77 |
| March | 9, 2019 | Spurs | 92 | Jazz | 79 |
| March | 10, 2019 | Rockets | 68 | Spurs | 79 |
| March | 11, 2019 | Spurs | 107 | Wolves | 69 |
| March | 12, 2019 | Jazz | 82 | Spurs | 103 |
| March | 14, 2019 | Spurs | 78 | Grizzlies | 74 |
| March | 19, 2019 | Mavericks | 62 | Spurs | 81 |
| March | 26, 2019 | Spurs | 91 | Raptors | 77 |
| March | 30, 2019 | Suns | 73 | Spurs | 66 |
| April | 4, 2019 | Spurs | 72 | Lakers | 76 |
| April | 10, 2019 | Spurs | 79 | Warriors | 63 |
| April | 12, 2019 | Spurs | 70 | Cavaliers | 81 |
| April | 16, 2019 | Lakers | 86 | Spurs | 80 |
| April | 20, 2019 | Spurs | 70 | Mavericks | 96 |
| April | 21, 2019 | Grizzlies | 81 | Spurs | 73 |
| April | 23, 2019 | 76ers | 62 | Spurs | 80 |
| April | 24, 2019 | Hornets | 88 | Spurs | 96 |
| April | 25, 2019 | Nuggets | 103 | Spurs | 71 |
| April | 27, 2019 | Pistons | 73 | Spurs | 84 |
| April | 29, 2019 | Cavaliers | 72 | Spurs | 94 |
| Post | 1, 2019 | Mavericks | 79 | Spurs | 70 |
| Post | 2, 2019 | Mavericks | 91 | Spurs | 79 |
| Post | 3, 2019 | Spurs | 91 | Mavericks | 92 |
| Post | 4, 2019 | Spurs | 65 | Mavericks | 56 |
| Post | 5, 2019 | Mavericks | 89 | Spurs | 75 |
| Post | 6, 2019 | Spurs | | Mavericks | |
| Post | 7, 2019 | Mavericks | | Spurs | |