| month | day | visitor | score | home | score |
|---|
| November | 2, 2022 | Pistons | 118 | Lakers | 104 |
| November | 3, 2022 | Pistons | 116 | Raptors | 114 |
| November | 4, 2022 | Pistons | 108 | Raptors | 121 |
| November | 6, 2022 | Pistons | 128 | Suns | 120 |
| November | 7, 2022 | Pistons | 95 | Celtics | 108 |
| November | 10, 2022 | Pistons | 98 | Bulls | 118 |
| November | 11, 2022 | Bulls | 111 | Pistons | 110 |
| November | 12, 2022 | Pistons | 119 | Grizzlies | 99 |
| November | 15, 2022 | Pistons | 108 | 76ers | 92 |
| November | 19, 2022 | Pistons | 104 | Timberwolves | 114 |
| November | 20, 2022 | Knicks | 106 | Pistons | 108 |
| November | 22, 2022 | Pistons | 120 | Jazz | 97 |
| November | 23, 2022 | Pistons | 98 | Heat | 131 |
| November | 24, 2022 | Pistons | 81 | Heat | 119 |
| November | 26, 2022 | Raptors | 82 | Pistons | 119 |
| November | 28, 2022 | Hornets | 97 | Pistons | 116 |
| November | 29, 2022 | Cavaliers | 96 | Pistons | 98 |
| November | 30, 2022 | Spurs | 102 | Pistons | 106 |
| December | 1, 2022 | Raptors | 104 | Pistons | 92 |
| December | 6, 2022 | 76ers | 89 | Pistons | 108 |
| December | 7, 2022 | Heat | 100 | Pistons | 128 |
| December | 8, 2022 | Pistons | 123 | 76ers | 105 |
| December | 9, 2022 | Raptors | 88 | Pistons | 105 |
| December | 10, 2022 | 76ers | 97 | Pistons | 117 |
| December | 11, 2022 | Cavaliers | 110 | Pistons | 100 |
| December | 14, 2022 | Pistons | 86 | Hornets | 106 |
| December | 21, 2022 | Pistons | 95 | Grizzlies | 64 |
| December | 22, 2022 | Timberwolves | 88 | Pistons | 117 |
| December | 23, 2022 | Pistons | 114 | Knicks | 116 |
| December | 25, 2022 | Bulls | 97 | Pistons | 108 |
| December | 27, 2022 | Pistons | 99 | Bulls | 111 |
| December | 31, 2022 | Pistons | 109 | Sonics | 123 |
| January | 2, 2023 | Pistons | 103 | Grizzlies | 91 |
| January | 3, 2023 | Pistons | 100 | Heat | 94 |
| January | 4, 2023 | Pistons | 104 | Cavaliers | 93 |
| January | 5, 2023 | Grizzlies | 122 | Pistons | 116 |
| January | 7, 2023 | Pistons | 89 | Raptors | 124 |
| January | 8, 2023 | Pistons | 97 | Celtics | 82 |
| January | 9, 2023 | Cavaliers | 100 | Pistons | 106 |
| January | 10, 2023 | Rockets | 95 | Pistons | 122 |
| January | 12, 2023 | Pistons | 102 | Knicks | 107 |
| January | 13, 2023 | Heat | 100 | Pistons | 122 |
| January | 14, 2023 | Hornets | 101 | Pistons | 109 |
| January | 15, 2023 | Pistons | 94 | Clippers | 100 |
| January | 16, 2023 | Pistons | 100 | Hornets | 113 |
| January | 17, 2023 | Raptors | 100 | Pistons | 107 |
| January | 18, 2023 | Pistons | 101 | Cavaliers | 93 |
| January | 20, 2023 | Grizzlies | 102 | Pistons | 115 |
| January | 26, 2023 | Pistons | 105 | Cavaliers | 103 |
| January | 27, 2023 | Jazz | 91 | Pistons | 101 |
| February | 5, 2023 | 76ers | | Pistons | |
| February | 7, 2023 | Pistons | | Warriors | |
| February | 9, 2023 | Bulls | | Pistons | |
| February | 10, 2023 | Suns | | Pistons | |
| February | 12, 2023 | Pistons | | Knicks | |
| February | 14, 2023 | Pistons | | 76ers | |
| February | 15, 2023 | Pistons | | Celtics | |
| February | 18, 2023 | Hornets | | Pistons | |
| February | 19, 2023 | Pistons | | Grizzlies | |
| February | 21, 2023 | Cavaliers | | Pistons | |
| February | 23, 2023 | Celtics | | Pistons | |
| February | 24, 2023 | Pistons | | Spurs | |
| February | 25, 2023 | Nuggets | | Pistons | |
| February | 26, 2023 | Pistons | | Knicks | |
| February | 27, 2023 | Bulls | | Pistons | |
| March | 4, 2023 | Lakers | | Pistons | |
| March | 10, 2023 | Grizzlies | | Pistons | |
| March | 12, 2023 | Pistons | | Nuggets | |
| March | 18, 2023 | Pistons | | Hornets | |
| March | 19, 2023 | Celtics | | Pistons | |
| March | 23, 2023 | Heat | | Pistons | |
| March | 25, 2023 | Pistons | | Rockets | |
| March | 26, 2023 | Pistons | | Heat | |
| March | 27, 2023 | Warriors | | Pistons | |
| March | 28, 2023 | Pistons | | Bulls | |
| March | 30, 2023 | Pistons | | Bulls | |
| April | 1, 2023 | Knicks | | Pistons | |
| April | 10, 2023 | Grizzlies | | Pistons | |
| April | 15, 2023 | Knicks | | Pistons | |
| April | 16, 2023 | Celtics | | Pistons | |
| April | 18, 2023 | Clippers | | Pistons | |
| April | 20, 2023 | Sonics | | Pistons | |