| month | day | visitor | score | home | score |
|---|
| November | 2, 2022 | Pistons | 110 | Bulls | 96 |
| November | 3, 2022 | Bulls | 116 | Pistons | 110 |
| November | 4, 2022 | Nuggets | 107 | Pistons | 132 |
| November | 10, 2022 | Pistons | 104 | Warriors | 109 |
| November | 11, 2022 | Pistons | 112 | 76ers | 85 |
| November | 13, 2022 | Timberwolves | 101 | Pistons | 113 |
| November | 15, 2022 | Pistons | 110 | Raptors | 136 |
| November | 16, 2022 | Pistons | 96 | Celtics | 114 |
| November | 17, 2022 | Grizzlies | 91 | Pistons | 126 |
| November | 19, 2022 | Pistons | 123 | Lakers | 114 |
| November | 20, 2022 | Pistons | 143 | Raptors | 124 |
| November | 22, 2022 | Pistons | 115 | Grizzlies | 83 |
| November | 23, 2022 | Raptors | 98 | Pistons | 106 |
| November | 24, 2022 | Spurs | 92 | Pistons | 119 |
| November | 26, 2022 | Pistons | 130 | Grizzlies | 125 |
| November | 27, 2022 | Pistons | 103 | Cavaliers | 107 |
| November | 28, 2022 | Pistons | 113 | Bulls | 115 |
| December | 1, 2022 | Heat | 120 | Pistons | 110 |
| December | 3, 2022 | Pistons | 121 | Knicks | 93 |
| December | 4, 2022 | Pistons | 120 | Hornets | 117 |
| December | 5, 2022 | Cavaliers | 106 | Pistons | 119 |
| December | 11, 2022 | Clippers | 76 | Pistons | 117 |
| December | 12, 2022 | Grizzlies | 92 | Pistons | 110 |
| December | 14, 2022 | Pistons | 99 | Heat | 121 |
| December | 19, 2022 | Rockets | 114 | Pistons | 99 |
| December | 20, 2022 | Heat | 127 | Pistons | 89 |
| December | 23, 2022 | Pistons | 102 | Knicks | 112 |
| December | 24, 2022 | Warriors | 105 | Pistons | 120 |
| December | 25, 2022 | Sonics | 86 | Pistons | 108 |
| December | 26, 2022 | 76ers | 91 | Pistons | 115 |
| December | 27, 2022 | 76ers | 92 | Pistons | 108 |
| December | 29, 2022 | Pistons | 101 | Heat | 98 |
| December | 30, 2022 | Pistons | 122 | Knicks | 131 |
| December | 31, 2022 | Cavaliers | 100 | Pistons | 119 |
| January | 1, 2023 | Pistons | 103 | Hornets | 109 |
| January | 2, 2023 | Pistons | 93 | Hornets | 121 |
| January | 4, 2023 | Grizzlies | 113 | Pistons | 103 |
| January | 9, 2023 | Celtics | 130 | Pistons | 112 |
| January | 10, 2023 | Lakers | 116 | Pistons | 125 |
| January | 12, 2023 | Pistons | 120 | Raptors | 103 |
| January | 16, 2023 | Raptors | 108 | Pistons | 106 |
| January | 17, 2023 | Hornets | 110 | Pistons | 116 |
| January | 19, 2023 | Pistons | 116 | Sonics | 104 |
| January | 20, 2023 | Pistons | 122 | Grizzlies | 131 |
| January | 22, 2023 | Bulls | 104 | Pistons | 126 |
| January | 24, 2023 | Pistons | 95 | Heat | 113 |
| January | 25, 2023 | Pistons | 120 | Knicks | 91 |
| January | 26, 2023 | Bulls | 103 | Pistons | 136 |
| January | 27, 2023 | Celtics | 111 | Pistons | 91 |
| February | 8, 2023 | Pistons | 118 | Bulls | 105 |
| February | 9, 2023 | Pistons | 89 | Celtics | 113 |
| February | 10, 2023 | Hornets | 127 | Pistons | 109 |
| February | 12, 2023 | Raptors | 114 | Pistons | 118 |
| February | 13, 2023 | Pistons | 100 | Spurs | 103 |
| February | 15, 2023 | Raptors | 94 | Pistons | 105 |
| February | 16, 2023 | Pistons | 95 | Heat | 118 |
| February | 18, 2023 | Pistons | 121 | 76ers | 99 |
| February | 19, 2023 | Jazz | 98 | Pistons | 139 |
| February | 22, 2023 | 76ers | 88 | Pistons | 124 |
| February | 24, 2023 | Hornets | 95 | Pistons | 108 |
| February | 25, 2023 | Suns | 103 | Pistons | 114 |
| February | 28, 2023 | Pistons | 92 | Jazz | 115 |
| March | 1, 2023 | Knicks | 98 | Pistons | 108 |
| March | 6, 2023 | Pistons | 118 | Clippers | 94 |
| March | 7, 2023 | Cavaliers | 94 | Pistons | 115 |
| March | 9, 2023 | Bulls | 95 | Pistons | 110 |
| March | 13, 2023 | Pistons | 101 | Bulls | 93 |
| March | 14, 2023 | Pistons | 119 | Nuggets | 97 |
| March | 15, 2023 | Knicks | 96 | Pistons | 112 |
| March | 17, 2023 | Pistons | 112 | Cavaliers | 83 |
| March | 18, 2023 | Pistons | 90 | Rockets | 92 |
| March | 20, 2023 | Heat | 117 | Pistons | 121 |
| March | 21, 2023 | Pistons | 106 | Celtics | 130 |
| March | 24, 2023 | Pistons | 117 | Cavaliers | 102 |
| March | 26, 2023 | Pistons | 124 | Suns | 116 |
| April | 1, 2023 | Knicks | 86 | Pistons | 115 |
| April | 2, 2023 | Celtics | 128 | Pistons | 105 |
| April | 6, 2023 | Pistons | 107 | Grizzlies | 95 |
| April | 12, 2023 | Pistons | 141 | Timberwolves | 121 |
| April | 15, 2023 | Grizzlies | 95 | Pistons | 99 |
| April | 17, 2023 | Pistons | 107 | 76ers | 98 |
| April | 18, 2023 | Cavaliers | 93 | Pistons | 109 |
| Post | 1, 2023 | Grizzlies | 101 | Pistons | 97 |
| Post | 2, 2023 | Grizzlies | 85 | Pistons | 99 |
| Post | 3, 2023 | Pistons | 107 | Grizzlies | 101 |
| Post | 4, 2023 | Pistons | 103 | Grizzlies | 97 |
| Post | 5, 2023 | Grizzlies | 94 | Pistons | 107 |
| Post | 6, 2023 | Pistons | | Grizzlies | |
| Post | 7, 2023 | Grizzlies | | Pistons | |
| Post | 8, 2023 | Pistons | 97 | Heat | 121 |
| Post | 9, 2023 | Pistons | 104 | Heat | 116 |
| Post | 10, 2023 | Heat | | Pistons | |
| Post | 11, 2023 | Heat | | Pistons | |
| Post | 12, 2023 | Pistons | | Heat | |
| Post | 13, 2023 | Heat | | Pistons | |
| Post | 14, 2023 | Pistons | | Heat | |