| month | day | visitor | score | home | score |
|---|
| November | 2, 2021 | Pistons | 114 | Lakers | 105 |
| November | 3, 2021 | Pistons | 109 | Raptors | 85 |
| November | 4, 2021 | Pistons | 117 | Raptors | 95 |
| November | 6, 2021 | Pistons | 102 | Suns | 110 |
| November | 7, 2021 | Pistons | 104 | Celtics | 117 |
| November | 10, 2021 | Pistons | 78 | Bulls | 81 |
| November | 11, 2021 | Bulls | 84 | Pistons | 59 |
| November | 12, 2021 | Pistons | 103 | Grizzlies | 116 |
| November | 15, 2021 | Pistons | 110 | 76ers | 115 |
| November | 19, 2021 | Pistons | 104 | Timberwolves | 113 |
| November | 20, 2021 | Knicks | 133 | Pistons | 101 |
| November | 22, 2021 | Pistons | 101 | Jazz | 94 |
| November | 23, 2021 | Pistons | 76 | Heat | 132 |
| November | 24, 2021 | Pistons | 87 | Heat | 105 |
| November | 26, 2021 | Raptors | 99 | Pistons | 117 |
| November | 28, 2021 | Hornets | 83 | Pistons | 108 |
| November | 29, 2021 | Cavaliers | 87 | Pistons | 100 |
| November | 30, 2021 | Spurs | 97 | Pistons | 107 |
| December | 1, 2021 | Raptors | 108 | Pistons | 118 |
| December | 6, 2021 | 76ers | 105 | Pistons | 116 |
| December | 7, 2021 | Heat | 103 | Pistons | 112 |
| December | 8, 2021 | Pistons | 111 | 76ers | 117 |
| December | 9, 2021 | Raptors | 97 | Pistons | 114 |
| December | 10, 2021 | 76ers | 99 | Pistons | 105 |
| December | 11, 2021 | Cavaliers | 107 | Pistons | 118 |
| December | 14, 2021 | Pistons | 83 | Hornets | 92 |
| December | 21, 2021 | Pistons | 84 | Grizzlies | 114 |
| December | 22, 2021 | Timberwolves | 103 | Pistons | 105 |
| December | 23, 2021 | Pistons | 104 | Knicks | 106 |
| December | 25, 2021 | Bulls | 108 | Pistons | 85 |
| December | 27, 2021 | Pistons | 73 | Bulls | 101 |
| December | 31, 2021 | Pistons | 91 | Sonics | 147 |
| January | 2, 2022 | Pistons | 108 | Grizzlies | 99 |
| January | 3, 2022 | Pistons | 101 | Heat | 123 |
| January | 4, 2022 | Pistons | 110 | Cavaliers | 88 |
| January | 5, 2022 | Grizzlies | 115 | Pistons | 108 |
| January | 7, 2022 | Pistons | 128 | Raptors | 121 |
| January | 8, 2022 | Pistons | 93 | Celtics | 126 |
| January | 9, 2022 | Cavaliers | 103 | Pistons | 104 |
| January | 10, 2022 | Rockets | 117 | Pistons | 100 |
| January | 12, 2022 | Pistons | 101 | Knicks | 125 |
| January | 13, 2022 | Heat | 97 | Pistons | 95 |
| January | 14, 2022 | Hornets | 91 | Pistons | 95 |
| January | 15, 2022 | Pistons | 95 | Clippers | 111 |
| January | 16, 2022 | Pistons | 93 | Hornets | 90 |
| January | 17, 2022 | Raptors | 95 | Pistons | 113 |
| January | 18, 2022 | Pistons | 100 | Cavaliers | 110 |
| January | 20, 2022 | Grizzlies | 105 | Pistons | 94 |
| January | 26, 2022 | Pistons | 95 | Cavaliers | 103 |
| January | 27, 2022 | Jazz | 83 | Pistons | 81 |
| February | 5, 2022 | 76ers | 100 | Pistons | 92 |
| February | 7, 2022 | Pistons | 101 | Warriors | 107 |
| February | 9, 2022 | Bulls | 91 | Pistons | 76 |
| February | 10, 2022 | Suns | 84 | Pistons | 110 |
| February | 12, 2022 | Pistons | 85 | Knicks | 110 |
| February | 14, 2022 | Pistons | 102 | 76ers | 106 |
| February | 15, 2022 | Pistons | 92 | Celtics | 136 |
| February | 18, 2022 | Hornets | 93 | Pistons | 104 |
| February | 19, 2022 | Pistons | 94 | Grizzlies | 102 |
| February | 21, 2022 | Cavaliers | 98 | Pistons | 108 |
| February | 23, 2022 | Celtics | 113 | Pistons | 115 |
| February | 24, 2022 | Pistons | 91 | Spurs | 102 |
| February | 25, 2022 | Nuggets | 89 | Pistons | 87 |
| February | 26, 2022 | Pistons | 78 | Knicks | 115 |
| February | 27, 2022 | Bulls | 94 | Pistons | 69 |
| March | 4, 2022 | Lakers | 97 | Pistons | 107 |
| March | 10, 2022 | Grizzlies | 73 | Pistons | 88 |
| March | 12, 2022 | Pistons | 118 | Nuggets | 113 |
| March | 18, 2022 | Pistons | 99 | Hornets | 101 |
| March | 19, 2022 | Celtics | 106 | Pistons | 105 |
| March | 23, 2022 | Heat | | Pistons | |
| March | 25, 2022 | Pistons | | Rockets | |
| March | 26, 2022 | Pistons | | Heat | |
| March | 27, 2022 | Warriors | | Pistons | |
| March | 28, 2022 | Pistons | | Bulls | |
| March | 30, 2022 | Pistons | | Bulls | |
| April | 1, 2022 | Knicks | | Pistons | |
| April | 10, 2022 | Grizzlies | | Pistons | |
| April | 15, 2022 | Knicks | | Pistons | |
| April | 16, 2022 | Celtics | | Pistons | |
| April | 18, 2022 | Clippers | | Pistons | |
| April | 20, 2022 | Sonics | | Pistons | |