| month | day | visitor | score | home | score |
|---|
| November | 4, 2021 | Knicks | 120 | Spurs | 103 |
| November | 5, 2021 | Spurs | 102 | Heat | 121 |
| November | 10, 2021 | Spurs | 108 | Wolves | 132 |
| November | 13, 2021 | Lakers | 89 | Spurs | 94 |
| November | 15, 2021 | Rockets | 114 | Spurs | 100 |
| November | 18, 2021 | Spurs | 100 | Mavericks | 119 |
| November | 19, 2021 | Grizzlies | 114 | Spurs | 90 |
| November | 22, 2021 | Jazz | 90 | Spurs | 116 |
| November | 27, 2021 | Jazz | 119 | Spurs | 100 |
| November | 29, 2021 | Suns | 112 | Spurs | 104 |
| December | 5, 2021 | Jazz | 104 | Spurs | 91 |
| December | 6, 2021 | Spurs | 108 | Clippers | 111 |
| December | 7, 2021 | Bucks | 117 | Spurs | 123 |
| December | 8, 2021 | Wolves | 83 | Spurs | 107 |
| December | 10, 2021 | Nuggets | 122 | Spurs | 100 |
| December | 11, 2021 | Warriors | 95 | Spurs | 132 |
| December | 13, 2021 | Hawks | 118 | Spurs | 116 |
| December | 15, 2021 | Spurs | 96 | Celtics | 136 |
| December | 17, 2021 | Spurs | 110 | Rockets | 125 |
| December | 20, 2021 | Spurs | 102 | Mavericks | 105 |
| December | 21, 2021 | Spurs | 102 | Pelicans | 119 |
| December | 22, 2021 | Mavericks | 116 | Spurs | 114 |
| December | 23, 2021 | Pacers | 115 | Spurs | 122 |
| December | 31, 2021 | Kings | 90 | Spurs | 93 |
| January | 1, 2022 | Blazers | 98 | Spurs | 95 |
| January | 2, 2022 | Nets | 106 | Spurs | 86 |
| January | 3, 2022 | Spurs | 106 | Kings | 110 |
| January | 5, 2022 | Lakers | 102 | Spurs | 115 |
| January | 7, 2022 | Spurs | 99 | Sonics | 98 |
| January | 8, 2022 | Sonics | 107 | Spurs | 113 |
| January | 9, 2022 | Spurs | 94 | Clippers | 111 |
| January | 11, 2022 | Clippers | 125 | Spurs | 115 |
| January | 14, 2022 | Spurs | 92 | Wolves | 78 |
| January | 17, 2022 | Spurs | 98 | Mavericks | 113 |
| January | 20, 2022 | Mavericks | 106 | Spurs | 99 |
| January | 21, 2022 | Clippers | 101 | Spurs | 104 |
| January | 25, 2022 | Spurs | 106 | Bulls | 120 |
| January | 27, 2022 | Spurs | 119 | Jazz | 110 |
| January | 28, 2022 | Blazers | 95 | Spurs | 102 |
| January | 29, 2022 | Spurs | 113 | Bucks | 117 |
| February | 1, 2022 | Kings | | Spurs | |
| February | 2, 2022 | Spurs | | Nuggets | |
| February | 4, 2022 | Heat | | Spurs | |
| February | 9, 2022 | Spurs | | Jazz | |
| February | 11, 2022 | Pelicans | | Spurs | |
| February | 12, 2022 | Warriors | | Spurs | |
| February | 13, 2022 | Spurs | | Kings | |
| February | 15, 2022 | Spurs | | Rockets | |
| February | 16, 2022 | Bulls | | Spurs | |
| February | 21, 2022 | Spurs | | Nuggets | |
| February | 24, 2022 | Wolves | | Spurs | |
| February | 26, 2022 | Spurs | | Hawks | |
| February | 28, 2022 | 76ers | | Spurs | |
| March | 2, 2022 | Spurs | | Knicks | |
| March | 3, 2022 | Spurs | | Sonics | |
| March | 4, 2022 | Spurs | | Nuggets | |
| March | 6, 2022 | Rockets | | Spurs | |
| March | 8, 2022 | Spurs | | Suns | |
| March | 9, 2022 | Spurs | | Lakers | |
| March | 11, 2022 | Sonics | | Spurs | |
| March | 12, 2022 | Spurs | | Lakers | |
| March | 15, 2022 | Mavericks | | Spurs | |
| March | 21, 2022 | Celtics | | Spurs | |
| March | 23, 2022 | Spurs | | Warriors | |
| March | 27, 2022 | Spurs | | Nets | |
| March | 29, 2022 | Spurs | | Grizzlies | |
| March | 30, 2022 | Spurs | | Suns | |
| April | 1, 2022 | Rockets | | Spurs | |
| April | 3, 2022 | Spurs | | Wolves | |
| April | 4, 2022 | Raptors | | Spurs | |
| April | 7, 2022 | Suns | | Spurs | |
| April | 8, 2022 | Spurs | | 76ers | |
| April | 9, 2022 | Spurs | | Warriors | |
| April | 10, 2022 | Nuggets | | Spurs | |
| April | 11, 2022 | Spurs | | Blazers | |
| April | 12, 2022 | Spurs | | Jazz | |
| April | 13, 2022 | Wolves | | Spurs | |
| April | 14, 2022 | Spurs | | Raptors | |
| April | 16, 2022 | Spurs | | Suns | |
| April | 22, 2022 | Spurs | | Blazers | |
| April | 24, 2022 | Spurs | | Pacers | |
| April | 25, 2022 | Nuggets | | Spurs | |