| month | day | visitor | score | home | score |
|---|
| November | 3, 2021 | Nuggets | 129 | Grizzlies | 98 |
| November | 6, 2021 | Grizzlies | 93 | Wolves | 108 |
| November | 11, 2021 | Warriors | 81 | Grizzlies | 115 |
| November | 13, 2021 | Grizzlies | 114 | Celtics | 124 |
| November | 17, 2021 | Grizzlies | 88 | Nets | 101 |
| November | 18, 2021 | Hawks | 103 | Grizzlies | 118 |
| November | 19, 2021 | Grizzlies | 114 | Spurs | 90 |
| November | 21, 2021 | Bulls | 108 | Grizzlies | 101 |
| November | 22, 2021 | Grizzlies | 126 | Heat | 114 |
| November | 23, 2021 | Pelicans | 118 | Grizzlies | 110 |
| November | 24, 2021 | Grizzlies | 79 | Knicks | 107 |
| November | 26, 2021 | Grizzlies | 101 | Celtics | 111 |
| November | 27, 2021 | Grizzlies | 118 | Pelicans | 130 |
| December | 5, 2021 | Nets | 82 | Grizzlies | 101 |
| December | 9, 2021 | Wolves | 96 | Grizzlies | 92 |
| December | 11, 2021 | Bulls | 102 | Grizzlies | 106 |
| December | 12, 2021 | Grizzlies | 130 | Pacers | 116 |
| December | 15, 2021 | Grizzlies | 109 | Lakers | 122 |
| December | 17, 2021 | Grizzlies | 90 | Suns | 87 |
| December | 18, 2021 | Raptors | 106 | Grizzlies | 100 |
| December | 23, 2021 | Grizzlies | 106 | Bucks | 92 |
| December | 24, 2021 | Grizzlies | 106 | Raptors | 111 |
| December | 25, 2021 | Grizzlies | 86 | 76ers | 92 |
| December | 28, 2021 | Grizzlies | 96 | Hawks | 78 |
| December | 30, 2021 | Grizzlies | 97 | Hawks | 101 |
| January | 1, 2022 | Grizzlies | 99 | Celtics | 109 |
| January | 2, 2022 | Celtics | 121 | Grizzlies | 120 |
| January | 3, 2022 | Jazz | 80 | Grizzlies | 106 |
| January | 4, 2022 | Grizzlies | 109 | 76ers | 86 |
| January | 10, 2022 | Grizzlies | 81 | Nets | 91 |
| January | 13, 2022 | Grizzlies | 107 | Pacers | 104 |
| January | 14, 2022 | Raptors | 114 | Grizzlies | 90 |
| January | 16, 2022 | Suns | 102 | Grizzlies | 110 |
| January | 19, 2022 | Grizzlies | 85 | Sonics | 87 |
| January | 22, 2022 | Grizzlies | 106 | Heat | 97 |
| January | 23, 2022 | Pacers | 103 | Grizzlies | 102 |
| January | 24, 2022 | Grizzlies | 90 | Knicks | 102 |
| January | 26, 2022 | Rockets | 93 | Grizzlies | 95 |
| January | 28, 2022 | Bulls | 94 | Grizzlies | 110 |
| January | 30, 2022 | Grizzlies | 88 | Knicks | 99 |
| February | 1, 2022 | Grizzlies | | Bucks | |
| February | 4, 2022 | Clippers | | Grizzlies | |
| February | 13, 2022 | 76ers | | Grizzlies | |
| February | 14, 2022 | Grizzlies | | Raptors | |
| February | 17, 2022 | Mavericks | | Grizzlies | |
| February | 18, 2022 | Bucks | | Grizzlies | |
| February | 19, 2022 | Bulls | | Grizzlies | |
| February | 20, 2022 | Grizzlies | | Bulls | |
| February | 21, 2022 | Grizzlies | | Pacers | |
| February | 24, 2022 | Bucks | | Grizzlies | |
| February | 25, 2022 | Bucks | | Grizzlies | |
| February | 26, 2022 | Bucks | | Grizzlies | |
| March | 3, 2022 | Lakers | | Grizzlies | |
| March | 5, 2022 | 76ers | | Grizzlies | |
| March | 8, 2022 | Grizzlies | | Rockets | |
| March | 9, 2022 | Kings | | Grizzlies | |
| March | 11, 2022 | Hawks | | Grizzlies | |
| March | 13, 2022 | Pelicans | | Grizzlies | |
| March | 14, 2022 | Raptors | | Grizzlies | |
| March | 16, 2022 | Grizzlies | | Bulls | |
| March | 18, 2022 | Grizzlies | | Raptors | |
| March | 20, 2022 | Sonics | | Grizzlies | |
| March | 21, 2022 | Grizzlies | | Nuggets | |
| March | 23, 2022 | Grizzlies | | Clippers | |
| March | 24, 2022 | Pelicans | | Grizzlies | |
| March | 26, 2022 | Grizzlies | | Jazz | |
| March | 29, 2022 | Spurs | | Grizzlies | |
| March | 30, 2022 | Grizzlies | | Nets | |
| April | 6, 2022 | Grizzlies | | Blazers | |
| April | 7, 2022 | Pacers | | Grizzlies | |
| April | 12, 2022 | Grizzlies | | Mavericks | |
| April | 13, 2022 | Blazers | | Grizzlies | |
| April | 14, 2022 | Heat | | Grizzlies | |
| April | 16, 2022 | Grizzlies | | Hawks | |
| April | 17, 2022 | Nets | | Grizzlies | |
| April | 18, 2022 | Grizzlies | | Kings | |
| April | 19, 2022 | Grizzlies | | Heat | |
| April | 20, 2022 | Heat | | Grizzlies | |
| April | 22, 2022 | Grizzlies | | Warriors | |
| April | 23, 2022 | Knicks | | Grizzlies | |
| April | 25, 2022 | Celtics | | Grizzlies | |
| April | 26, 2022 | Knicks | | Grizzlies | |