| month | day | visitor | score | home | score |
|---|
| November | 9, 2020 | Rockets | 133 | Warriors | 110 |
| November | 11, 2020 | Sonics | 75 | Rockets | 111 |
| November | 12, 2020 | Rockets | 97 | Heat | 96 |
| November | 14, 2020 | Rockets | 105 | Suns | 85 |
| November | 15, 2020 | Rockets | 104 | Spurs | 114 |
| November | 16, 2020 | Wolves | 108 | Rockets | 122 |
| November | 18, 2020 | Rockets | 98 | Celtics | 120 |
| November | 20, 2020 | Rockets | 105 | Nuggets | 103 |
| November | 23, 2020 | Rockets | 125 | Wolves | 121 |
| November | 24, 2020 | Mavericks | 91 | Rockets | 95 |
| November | 26, 2020 | Rockets | 123 | Blazers | 102 |
| November | 27, 2020 | Raptors | 125 | Rockets | 120 |
| November | 29, 2020 | Rockets | 124 | Warriors | 116 |
| November | 30, 2020 | Jazz | 99 | Rockets | 119 |
| December | 1, 2020 | Rockets | 116 | Nuggets | 112 |
| December | 3, 2020 | Rockets | 71 | Lakers | 117 |
| December | 4, 2020 | Rockets | 126 | 76ers | 82 |
| December | 10, 2020 | Warriors | 107 | Rockets | 122 |
| December | 12, 2020 | Clippers | 80 | Rockets | 101 |
| December | 15, 2020 | Kings | 97 | Rockets | 112 |
| December | 17, 2020 | Spurs | 104 | Rockets | 113 |
| December | 19, 2020 | Rockets | 134 | Sonics | 102 |
| December | 21, 2020 | Kings | 111 | Rockets | 117 |
| December | 22, 2020 | Pacers | 109 | Rockets | 111 |
| December | 25, 2020 | Rockets | 109 | Suns | 122 |
| December | 26, 2020 | Suns | 114 | Rockets | 136 |
| December | 27, 2020 | Rockets | 100 | Jazz | 96 |
| December | 30, 2020 | Bulls | 108 | Rockets | 123 |
| December | 31, 2020 | Mavericks | 95 | Rockets | 94 |
| January | 1, 2021 | Clippers | 106 | Rockets | 105 |
| January | 2, 2021 | Rockets | 108 | Lakers | 104 |
| January | 3, 2021 | Nuggets | 96 | Rockets | 131 |
| January | 4, 2021 | Rockets | 106 | Suns | 92 |
| January | 6, 2021 | Hawks | 100 | Rockets | 128 |
| January | 8, 2021 | Suns | 81 | Rockets | 138 |
| January | 10, 2021 | Pelicans | 119 | Rockets | 140 |
| January | 12, 2021 | Heat | 73 | Rockets | 123 |
| January | 13, 2021 | Sonics | 98 | Rockets | 121 |
| January | 14, 2021 | Nuggets | 93 | Rockets | 132 |
| January | 15, 2021 | Mavericks | 91 | Rockets | 94 |
| January | 18, 2021 | Lakers | 115 | Rockets | 126 |
| January | 20, 2021 | Rockets | 119 | Pelicans | 110 |
| January | 22, 2021 | Rockets | 95 | Mavericks | 87 |
| January | 24, 2021 | Rockets | 125 | Kings | 89 |
| January | 25, 2021 | 76ers | 89 | Rockets | 111 |
| January | 26, 2021 | Rockets | 89 | Grizzlies | 111 |
| January | 29, 2021 | Rockets | 94 | Kings | 85 |
| February | 1, 2021 | Rockets | 129 | Raptors | 124 |
| February | 2, 2021 | Rockets | 106 | Jazz | 95 |
| February | 8, 2021 | Blazers | 108 | Rockets | 128 |
| February | 14, 2021 | Rockets | 118 | Knicks | 105 |
| February | 15, 2021 | Spurs | 102 | Rockets | 115 |
| February | 16, 2021 | Jazz | 90 | Rockets | 109 |
| February | 19, 2021 | Rockets | 107 | Mavericks | 105 |
| February | 20, 2021 | Lakers | 104 | Rockets | 120 |
| February | 26, 2021 | Rockets | 130 | Wolves | 115 |
| February | 27, 2021 | Jazz | 93 | Rockets | 105 |
| March | 3, 2021 | Rockets | 123 | Bucks | 124 |
| March | 4, 2021 | Rockets | 126 | Hawks | 113 |
| March | 5, 2021 | Rockets | 118 | Sonics | 95 |
| March | 6, 2021 | Rockets | 109 | Spurs | 100 |
| March | 8, 2021 | Grizzlies | 103 | Rockets | 120 |
| March | 9, 2021 | Rockets | 121 | Blazers | 124 |
| March | 10, 2021 | Nets | 119 | Rockets | 115 |
| March | 12, 2021 | Blazers | 94 | Rockets | 122 |
| March | 13, 2021 | Rockets | 90 | Mavericks | 118 |
| March | 14, 2021 | Wolves | 114 | Rockets | 134 |
| March | 16, 2021 | Suns | 93 | Rockets | 103 |
| March | 20, 2021 | Nuggets | 95 | Rockets | 99 |
| March | 22, 2021 | Warriors | 94 | Rockets | 122 |
| March | 25, 2021 | Knicks | 91 | Rockets | 103 |
| March | 27, 2021 | Rockets | 108 | Bulls | 102 |
| March | 28, 2021 | Rockets | 104 | Nets | 109 |
| March | 30, 2021 | Rockets | 115 | Clippers | 97 |
| March | 31, 2021 | Wolves | 115 | Rockets | 114 |
| April | 1, 2021 | Rockets | 97 | Spurs | 101 |
| April | 3, 2021 | Bucks | 109 | Rockets | 118 |
| April | 7, 2021 | Rockets | 110 | Wolves | 113 |
| April | 8, 2021 | Rockets | 97 | Jazz | 85 |
| April | 17, 2021 | Rockets | 108 | Clippers | 93 |
| April | 23, 2021 | Rockets | 124 | Pacers | 116 |
| April | 26, 2021 | Celtics | 109 | Rockets | 112 |
| Post | 1, 2021 | Spurs | 108 | Rockets | 122 |
| Post | 2, 2021 | Spurs | 110 | Rockets | 130 |
| Post | 3, 2021 | Rockets | 112 | Spurs | 129 |
| Post | 4, 2021 | Rockets | 124 | Spurs | 105 |
| Post | 5, 2021 | Spurs | 96 | Rockets | 109 |
| Post | 6, 2021 | Rockets | | Spurs | |
| Post | 7, 2021 | Spurs | | Rockets | |
| Post | 8, 2021 | Nuggets | 94 | Rockets | 112 |
| Post | 9, 2021 | Nuggets | 99 | Rockets | 122 |
| Post | 10, 2021 | Rockets | 120 | Nuggets | 99 |
| Post | 11, 2021 | Rockets | 101 | Nuggets | 104 |
| Post | 12, 2021 | Nuggets | 83 | Rockets | 91 |
| Post | 13, 2021 | Rockets | | Nuggets | |
| Post | 14, 2021 | Nuggets | | Rockets | |
| Post | 15, 2021 | Lakers | 88 | Rockets | 113 |
| Post | 16, 2021 | Lakers | 101 | Rockets | 107 |
| Post | 17, 2021 | Rockets | 102 | Lakers | 97 |
| Post | 18, 2021 | Rockets | 123 | Lakers | 103 |
| Post | 19, 2021 | Lakers | | Rockets | |
| Post | 20, 2021 | Rockets | | Lakers | |
| Post | 21, 2021 | Lakers | | Rockets | |
| Post | 22, 2021 | Pelicans | 107 | Rockets | 122 |
| Post | 23, 2021 | Pelicans | 112 | Rockets | 125 |
| Post | 24, 2021 | Rockets | 106 | Pelicans | 116 |
| Post | 25, 2021 | Rockets | 100 | Pelicans | 121 |
| Post | 26, 2021 | Rockets | 108 | Pelicans | 132 |
| Post | 27, 2021 | Pelicans | 140 | Rockets | 110 |