| month | day | visitor | score | home | score |
|---|
| November | 3, 2020 | Nuggets | 96 | Grizzlies | 113 |
| November | 6, 2020 | Grizzlies | 100 | Wolves | 97 |
| November | 11, 2020 | Warriors | 110 | Grizzlies | 125 |
| November | 13, 2020 | Grizzlies | 84 | Celtics | 120 |
| November | 17, 2020 | Grizzlies | 107 | Nets | 114 |
| November | 18, 2020 | Hawks | 107 | Grizzlies | 124 |
| November | 19, 2020 | Grizzlies | 113 | Spurs | 111 |
| November | 21, 2020 | Bulls | 83 | Grizzlies | 109 |
| November | 22, 2020 | Grizzlies | 107 | Heat | 99 |
| November | 23, 2020 | Pelicans | 117 | Grizzlies | 92 |
| November | 24, 2020 | Grizzlies | 105 | Knicks | 112 |
| November | 26, 2020 | Grizzlies | 84 | Celtics | 108 |
| November | 27, 2020 | Grizzlies | 107 | Pelicans | 110 |
| December | 5, 2020 | Nets | 94 | Grizzlies | 95 |
| December | 9, 2020 | Wolves | 120 | Grizzlies | 119 |
| December | 11, 2020 | Bulls | 100 | Grizzlies | 105 |
| December | 12, 2020 | Grizzlies | 99 | Pacers | 102 |
| December | 15, 2020 | Grizzlies | 114 | Lakers | 137 |
| December | 17, 2020 | Grizzlies | 127 | Suns | 118 |
| December | 18, 2020 | Raptors | 97 | Grizzlies | 113 |
| December | 23, 2020 | Grizzlies | 109 | Bucks | 115 |
| December | 24, 2020 | Grizzlies | 109 | Raptors | 130 |
| December | 25, 2020 | Grizzlies | 105 | 76ers | 127 |
| December | 28, 2020 | Grizzlies | 114 | Hawks | 123 |
| December | 30, 2020 | Grizzlies | 112 | Hawks | 119 |
| January | 1, 2021 | Grizzlies | 98 | Celtics | 121 |
| January | 2, 2021 | Celtics | 121 | Grizzlies | 103 |
| January | 3, 2021 | Jazz | 103 | Grizzlies | 99 |
| January | 4, 2021 | Grizzlies | 106 | 76ers | 123 |
| January | 10, 2021 | Grizzlies | 101 | Nets | 96 |
| January | 13, 2021 | Grizzlies | 86 | Pacers | 105 |
| January | 14, 2021 | Raptors | 126 | Grizzlies | 106 |
| January | 16, 2021 | Suns | 112 | Grizzlies | 102 |
| January | 19, 2021 | Grizzlies | 108 | Sonics | 118 |
| January | 22, 2021 | Grizzlies | 108 | Heat | 109 |
| January | 23, 2021 | Pacers | 107 | Grizzlies | 101 |
| January | 24, 2021 | Grizzlies | 102 | Knicks | 121 |
| January | 26, 2021 | Rockets | 89 | Grizzlies | 111 |
| January | 28, 2021 | Bulls | 119 | Grizzlies | 110 |
| January | 30, 2021 | Grizzlies | 95 | Knicks | 106 |
| February | 1, 2021 | Grizzlies | 107 | Bucks | 110 |
| February | 4, 2021 | Clippers | 108 | Grizzlies | 90 |
| February | 13, 2021 | 76ers | 88 | Grizzlies | 81 |
| February | 14, 2021 | Grizzlies | 93 | Raptors | 107 |
| February | 17, 2021 | Mavericks | 104 | Grizzlies | 64 |
| February | 18, 2021 | Bucks | 119 | Grizzlies | 108 |
| February | 19, 2021 | Bulls | 121 | Grizzlies | 98 |
| February | 20, 2021 | Grizzlies | 88 | Bulls | 126 |
| February | 21, 2021 | Grizzlies | 81 | Pacers | 103 |
| February | 24, 2021 | Bucks | 107 | Grizzlies | 89 |
| February | 25, 2021 | Bucks | 110 | Grizzlies | 95 |
| February | 26, 2021 | Bucks | 119 | Grizzlies | 77 |
| March | 3, 2021 | Lakers | 112 | Grizzlies | 88 |
| March | 5, 2021 | 76ers | 99 | Grizzlies | 98 |
| March | 8, 2021 | Grizzlies | 103 | Rockets | 120 |
| March | 9, 2021 | Kings | 84 | Grizzlies | 98 |
| March | 11, 2021 | Hawks | 116 | Grizzlies | 121 |
| March | 13, 2021 | Pelicans | 125 | Grizzlies | 102 |
| March | 14, 2021 | Raptors | 105 | Grizzlies | 79 |
| March | 16, 2021 | Grizzlies | 86 | Bulls | 122 |
| March | 18, 2021 | Grizzlies | 88 | Raptors | 96 |
| March | 20, 2021 | Sonics | 100 | Grizzlies | 87 |
| March | 21, 2021 | Grizzlies | 91 | Nuggets | 107 |
| March | 23, 2021 | Grizzlies | 90 | Clippers | 106 |
| March | 24, 2021 | Pelicans | 138 | Grizzlies | 92 |
| March | 26, 2021 | Grizzlies | 77 | Jazz | 104 |
| March | 29, 2021 | Spurs | 104 | Grizzlies | 80 |
| March | 30, 2021 | Grizzlies | 92 | Nets | 112 |
| April | 6, 2021 | Grizzlies | 102 | Blazers | 127 |
| April | 7, 2021 | Pacers | 103 | Grizzlies | 88 |
| April | 12, 2021 | Grizzlies | 72 | Mavericks | 96 |
| April | 13, 2021 | Blazers | 121 | Grizzlies | 119 |
| April | 14, 2021 | Heat | 94 | Grizzlies | 77 |
| April | 16, 2021 | Grizzlies | 96 | Hawks | 115 |
| April | 17, 2021 | Nets | 145 | Grizzlies | 80 |
| April | 18, 2021 | Grizzlies | 76 | Kings | 88 |
| April | 19, 2021 | Grizzlies | 82 | Heat | 92 |
| April | 20, 2021 | Heat | 79 | Grizzlies | 70 |
| April | 22, 2021 | Grizzlies | 101 | Warriors | 125 |
| April | 23, 2021 | Knicks | 107 | Grizzlies | 96 |
| April | 25, 2021 | Celtics | 102 | Grizzlies | 86 |
| April | 26, 2021 | Knicks | 101 | Grizzlies | 94 |