| month | day | visitor | score | home | score |
|---|
| November | 3, 2021 | Raptors | 80 | Celtics | 100 |
| November | 4, 2021 | Wizards | 107 | Raptors | 99 |
| November | 5, 2021 | Celtics | 100 | Raptors | 91 |
| November | 6, 2021 | Raptors | 89 | Nets | 126 |
| November | 8, 2021 | Raptors | 89 | Hornets | 96 |
| November | 9, 2021 | Raptors | 92 | Cavaliers | 105 |
| November | 11, 2021 | Hornets | 107 | Raptors | 91 |
| November | 13, 2021 | Raptors | 81 | Bulls | 85 |
| November | 18, 2021 | Pistons | 87 | Raptors | 115 |
| November | 23, 2021 | Knicks | 106 | Raptors | 116 |
| November | 25, 2021 | Raptors | 95 | Hawks | 96 |
| November | 28, 2021 | Raptors | 84 | Wizards | 90 |
| December | 1, 2021 | Raptors | 103 | Knicks | 111 |
| December | 8, 2021 | Cavaliers | 102 | Raptors | 107 |
| December | 14, 2021 | Raptors | 98 | Hawks | 105 |
| December | 15, 2021 | Raptors | 111 | Pistons | 93 |
| December | 16, 2021 | Raptors | 101 | Bucks | 112 |
| December | 18, 2021 | Nets | 107 | Raptors | 93 |
| December | 20, 2021 | Magic | 79 | Raptors | 96 |
| December | 23, 2021 | Pistons | 101 | Raptors | 107 |
| December | 28, 2021 | Bulls | 112 | Raptors | 93 |
| December | 30, 2021 | Raptors | 94 | Magic | 91 |
| January | 1, 2022 | Raptors | 100 | Pacers | 65 |
| January | 3, 2022 | 76ers | 65 | Raptors | 90 |
| January | 4, 2022 | Raptors | 67 | 76ers | 95 |
| January | 5, 2022 | Pacers | 108 | Raptors | 107 |
| January | 6, 2022 | Heat | 86 | Raptors | 80 |
| January | 7, 2022 | Raptors | 95 | Heat | 111 |
| January | 8, 2022 | Hawks | 121 | Raptors | 100 |
| January | 9, 2022 | Pacers | 75 | Raptors | 98 |
| January | 11, 2022 | Raptors | 108 | Hornets | 118 |
| January | 12, 2022 | Bucks | 86 | Raptors | 107 |