| month | day | visitor | score | home | score |
|---|
| November | 3, 2021 | Bucks | 92 | Pistons | 60 |
| November | 4, 2021 | Bulls | 82 | Pistons | 81 |
| November | 7, 2021 | Pistons | 62 | Wizards | 95 |
| November | 10, 2021 | Pacers | 78 | Pistons | 81 |
| November | 11, 2021 | Heat | 98 | Pistons | 56 |
| November | 15, 2021 | Pistons | 90 | Hornets | 98 |
| November | 16, 2021 | Pistons | 75 | Bucks | 86 |
| November | 18, 2021 | Pistons | 87 | Raptors | 115 |
| November | 21, 2021 | Hawks | 83 | Pistons | 85 |
| November | 23, 2021 | Cavaliers | 69 | Pistons | 83 |
| November | 30, 2021 | Pistons | 95 | Hawks | 108 |
| December | 2, 2021 | Pistons | 61 | Cavaliers | 101 |
| December | 3, 2021 | Magic | 98 | Pistons | 79 |
| December | 4, 2021 | Pistons | 74 | Heat | 99 |
| December | 7, 2021 | Celtics | 75 | Pistons | 66 |
| December | 13, 2021 | Pistons | 61 | Bulls | 95 |
| December | 15, 2021 | Raptors | 111 | Pistons | 93 |
| December | 18, 2021 | Pacers | 79 | Pistons | 71 |
| December | 19, 2021 | Wizards | 63 | Pistons | 70 |
| December | 22, 2021 | Pistons | 77 | Nets | 92 |
| December | 23, 2021 | Pistons | 101 | Raptors | 107 |
| December | 24, 2021 | Pistons | 71 | Celtics | 89 |
| December | 26, 2021 | Hornets | 94 | Pistons | 71 |
| December | 27, 2021 | Pistons | 80 | 76ers | 72 |
| December | 28, 2021 | Pistons | 75 | Hornets | 104 |
| December | 31, 2021 | 76ers | 83 | Pistons | 90 |
| January | 1, 2022 | Knicks | 103 | Pistons | 79 |
| January | 2, 2022 | Pistons | 85 | Magic | 82 |
| January | 3, 2022 | Pistons | 73 | Pacers | 83 |
| January | 4, 2022 | Hawks | 94 | Pistons | 68 |
| January | 6, 2022 | Pistons | 60 | Knicks | 93 |
| January | 10, 2022 | Nets | 111 | Pistons | 94 |