| month | day | visitor | score | home | score |
|---|
| November | 2, 2021 | Magic | 71 | 76ers | 75 |
| November | 4, 2021 | 76ers | 91 | Knicks | 102 |
| November | 6, 2021 | 76ers | 70 | Cavaliers | 80 |
| November | 10, 2021 | Hawks | 89 | 76ers | 85 |
| November | 12, 2021 | Hornets | 84 | 76ers | 92 |
| November | 14, 2021 | Magic | 89 | 76ers | 92 |
| November | 20, 2021 | 76ers | 90 | Pacers | 78 |
| November | 23, 2021 | 76ers | 72 | Celtics | 108 |
| November | 25, 2021 | Pacers | 69 | 76ers | 91 |
| November | 26, 2021 | 76ers | 99 | Hawks | 95 |
| November | 27, 2021 | Wizards | 68 | 76ers | 93 |
| November | 28, 2021 | Knicks | 97 | 76ers | 93 |
| November | 29, 2021 | Nets | 79 | 76ers | 91 |
| December | 1, 2021 | 76ers | 80 | Heat | 89 |
| December | 3, 2021 | 76ers | 85 | Nets | 94 |
| December | 7, 2021 | 76ers | 98 | Hornets | 97 |
| December | 19, 2021 | 76ers | 82 | Celtics | 73 |
| December | 22, 2021 | 76ers | 69 | Heat | 96 |
| December | 24, 2021 | 76ers | 71 | Bulls | 81 |
| December | 25, 2021 | Cavaliers | 87 | 76ers | 69 |
| December | 26, 2021 | Knicks | 93 | 76ers | 58 |
| December | 27, 2021 | Pistons | 80 | 76ers | 72 |
| December | 28, 2021 | Heat | 93 | 76ers | 64 |
| December | 31, 2021 | 76ers | 83 | Pistons | 90 |
| January | 1, 2022 | 76ers | 57 | Wizards | 74 |
| January | 3, 2022 | 76ers | 65 | Raptors | 90 |
| January | 4, 2022 | Raptors | 67 | 76ers | 95 |
| January | 6, 2022 | Celtics | 75 | 76ers | 74 |
| January | 7, 2022 | Bucks | 72 | 76ers | 82 |
| January | 8, 2022 | Bulls | 77 | 76ers | 65 |
| January | 10, 2022 | 76ers | 82 | Bucks | 103 |
| January | 13, 2022 | 76ers | 77 | Magic | 76 |