| month | day | visitor | score | home | score |
|---|
| November | 2, 2005 | Kings | 85 | Spurs | 91 |
| November | 6, 2005 | Kings | 87 | Spurs | 104 |
| November | 9, 2005 | Spurs | 91 | Blazers | 109 |
| November | 10, 2005 | Grizzlies | 107 | Spurs | 91 |
| November | 12, 2005 | Nets | 91 | Spurs | 82 |
| November | 14, 2005 | Spurs | 78 | Bobcats | 98 |
| November | 18, 2005 | Spurs | 90 | Kings | 108 |
| November | 24, 2005 | Spurs | 78 | Kings | 104 |
| November | 26, 2005 | Kings | 84 | Spurs | 104 |
| November | 27, 2005 | Spurs | 76 | Suns | 82 |
| November | 28, 2005 | Spurs | 88 | Nets | 109 |
| November | 30, 2005 | Blazers | 99 | Spurs | 91 |
| December | 1, 2005 | Blazers | 83 | Spurs | 102 |
| December | 3, 2005 | Wizards | 93 | Spurs | 98 |
| December | 7, 2005 | Spurs | 98 | Bucks | 104 |
| December | 10, 2005 | Spurs | 94 | Suns | 68 |
| December | 16, 2005 | Spurs | 93 | Blazers | 87 |
| December | 17, 2005 | Spurs | 75 | Suns | 87 |
| December | 21, 2005 | Spurs | 98 | Grizzlies | 127 |
| December | 23, 2005 | Bucks | 107 | Spurs | 101 |
| December | 26, 2005 | Suns | 100 | Spurs | 93 |
| January | 3, 2006 | Spurs | 101 | Blazers | 87 |
| January | 4, 2006 | Suns | 70 | Spurs | 103 |
| January | 5, 2006 | Suns | 83 | Spurs | 102 |
| January | 6, 2006 | Grizzlies | 111 | Spurs | 101 |
| January | 7, 2006 | Spurs | 77 | Blazers | 108 |
| January | 8, 2006 | Spurs | 83 | Kings | 106 |
| January | 9, 2006 | Bobcats | 91 | Spurs | 112 |
| January | 11, 2006 | Grizzlies | 89 | Spurs | 98 |
| January | 12, 2006 | Spurs | 75 | Wizards | 115 |
| January | 14, 2006 | Suns | 88 | Spurs | 92 |
| January | 15, 2006 | Spurs | 86 | Grizzlies | 95 |