| month | day | visitor | score | home | score |
|---|
| November | 2, 2021 | Spurs | 90 | Celtics | 123 |
| November | 3, 2021 | Spurs | 81 | Jazz | 90 |
| November | 7, 2021 | Spurs | 83 | Rockets | 87 |
| November | 8, 2021 | Nuggets | 79 | Spurs | 93 |
| November | 10, 2021 | Spurs | 90 | Suns | 91 |
| November | 12, 2021 | Spurs | 90 | Rockets | 95 |
| November | 13, 2021 | Spurs | 69 | Jazz | 78 |
| November | 14, 2021 | Rockets | 88 | Spurs | 81 |
| November | 18, 2021 | Spurs | 78 | Nuggets | 81 |
| November | 21, 2021 | Spurs | 88 | Grizzlies | 111 |
| November | 27, 2021 | Spurs | 77 | Jazz | 92 |
| November | 29, 2021 | Spurs | 96 | Suns | 94 |
| November | 30, 2021 | Spurs | 97 | Pistons | 107 |
| December | 2, 2021 | Spurs | 93 | Nuggets | 73 |
| December | 5, 2021 | Timberwolves | 90 | Spurs | 95 |
| December | 6, 2021 | Spurs | 91 | Lakers | 110 |
| December | 7, 2021 | Rockets | 89 | Spurs | 83 |
| December | 9, 2021 | Sonics | 102 | Spurs | 100 |
| December | 10, 2021 | Jazz | 71 | Spurs | 96 |
| December | 11, 2021 | Rockets | 84 | Spurs | 93 |
| December | 12, 2021 | Suns | 94 | Spurs | 102 |
| December | 14, 2021 | Timberwolves | 89 | Spurs | 88 |
| December | 15, 2021 | Rockets | 85 | Spurs | 88 |
| December | 16, 2021 | Knicks | 109 | Spurs | 108 |
| December | 17, 2021 | Lakers | 79 | Spurs | 90 |
| December | 18, 2021 | 76ers | 114 | Spurs | 109 |
| December | 19, 2021 | Spurs | 98 | Sonics | 91 |
| December | 20, 2021 | Spurs | 97 | Timberwolves | 84 |
| December | 25, 2021 | Spurs | 90 | Clippers | 100 |
| December | 26, 2021 | Spurs | 107 | Jazz | 80 |
| December | 29, 2021 | Spurs | 79 | Nuggets | 90 |
| December | 30, 2021 | Clippers | 113 | Spurs | 106 |
| December | 31, 2021 | Lakers | 79 | Spurs | 107 |
| January | 3, 2022 | Timberwolves | 96 | Spurs | 107 |
| January | 7, 2022 | Spurs | 104 | Nuggets | 112 |
| January | 8, 2022 | Spurs | 89 | Clippers | 95 |
| January | 9, 2022 | Lakers | 90 | Spurs | 93 |
| January | 11, 2022 | Heat | 98 | Spurs | 89 |
| January | 12, 2022 | Spurs | 99 | Sonics | 91 |
| January | 19, 2022 | Raptors | 100 | Spurs | 88 |
| January | 23, 2022 | Warriors | 104 | Spurs | 132 |
| January | 24, 2022 | Spurs | 96 | 76ers | 130 |
| January | 25, 2022 | Cavaliers | 78 | Spurs | 101 |
| January | 26, 2022 | Timberwolves | 97 | Spurs | 109 |
| February | 5, 2022 | Spurs | 111 | Timberwolves | 82 |
| February | 6, 2022 | Spurs | 98 | Knicks | 116 |
| February | 9, 2022 | Jazz | 87 | Spurs | 98 |
| February | 12, 2022 | Grizzlies | 95 | Spurs | 93 |
| February | 15, 2022 | Sonics | 94 | Spurs | 95 |
| February | 16, 2022 | Spurs | 97 | Lakers | 65 |
| February | 18, 2022 | Bulls | 96 | Spurs | 86 |
| February | 20, 2022 | Warriors | 101 | Spurs | 111 |
| February | 21, 2022 | Rockets | 102 | Spurs | 95 |
| February | 22, 2022 | Spurs | 89 | Hornets | 76 |
| February | 24, 2022 | Pistons | 91 | Spurs | 102 |
| February | 26, 2022 | Hornets | 85 | Spurs | 80 |
| February | 28, 2022 | Nuggets | 112 | Spurs | 103 |
| March | 1, 2022 | Spurs | 113 | Warriors | 117 |
| March | 3, 2022 | Jazz | 79 | Spurs | 93 |
| March | 4, 2022 | Spurs | 111 | Heat | 125 |
| March | 5, 2022 | Clippers | 84 | Spurs | 81 |
| March | 7, 2022 | Suns | 100 | Spurs | 90 |
| March | 8, 2022 | Lakers | 78 | Spurs | 94 |
| March | 10, 2022 | Spurs | 92 | Nuggets | 84 |
| March | 11, 2022 | Sonics | 98 | Spurs | 97 |
| March | 15, 2022 | Sonics | 95 | Spurs | 104 |
| March | 18, 2022 | Suns | 84 | Spurs | 110 |
| March | 19, 2022 | Warriors | 111 | Spurs | 102 |
| March | 20, 2022 | Spurs | 108 | Raptors | 90 |
| March | 22, 2022 | Spurs | 124 | Warriors | 113 |
| March | 24, 2022 | Spurs | 85 | Bulls | 104 |
| March | 29, 2022 | Spurs | 96 | Jazz | 72 |
| March | 31, 2022 | Spurs | 109 | Warriors | 103 |
| April | 1, 2022 | Celtics | 93 | Spurs | 89 |
| April | 2, 2022 | Spurs | 91 | Sonics | 106 |
| April | 6, 2022 | Suns | 100 | Spurs | 93 |
| April | 8, 2022 | Spurs | 106 | Clippers | 78 |
| April | 9, 2022 | Spurs | 92 | Suns | 88 |
| April | 11, 2022 | Spurs | 90 | Clippers | 95 |
| April | 16, 2022 | Spurs | 88 | Timberwolves | 118 |
| April | 18, 2022 | Spurs | 99 | Cavaliers | 93 |
| April | 20, 2022 | Spurs | 74 | Lakers | 85 |
| Post | 1, 2022 | Spurs | 92 | Rockets | 94 |
| Post | 2, 2022 | Spurs | 86 | Rockets | 102 |
| Post | 3, 2022 | Rockets | 85 | Spurs | 93 |
| Post | 4, 2022 | Rockets | 85 | Spurs | 91 |
| Post | 5, 2022 | Spurs | 84 | Rockets | 77 |
| Post | 6, 2022 | Rockets | 88 | Spurs | 95 |
| Post | 7, 2022 | Spurs | | Rockets | |
| Post | 8, 2022 | Spurs | 75 | Clippers | 99 |
| Post | 9, 2022 | Spurs | 92 | Clippers | 76 |
| Post | 10, 2022 | Clippers | 102 | Spurs | 92 |
| Post | 11, 2022 | Clippers | 80 | Spurs | 83 |
| Post | 12, 2022 | Spurs | 73 | Clippers | 81 |
| Post | 13, 2022 | Clippers | 71 | Spurs | 107 |
| Post | 14, 2022 | Spurs | 93 | Clippers | 91 |
| Post | 15, 2022 | Spurs | 102 | Nuggets | 109 |
| Post | 16, 2022 | Spurs | 104 | Nuggets | 109 |
| Post | 17, 2022 | Nuggets | 108 | Spurs | 98 |
| Post | 18, 2022 | Nuggets | 95 | Spurs | 111 |
| Post | 19, 2022 | Spurs | 95 | Nuggets | 87 |
| Post | 20, 2022 | Nuggets | 94 | Spurs | 95 |
| Post | 21, 2022 | Spurs | 96 | Nuggets | 86 |
| Post | 22, 2022 | Spurs | 97 | Heat | 107 |
| Post | 23, 2022 | Spurs | 100 | Heat | 104 |
| Post | 24, 2022 | Heat | 96 | Spurs | 98 |
| Post | 25, 2022 | Heat | 110 | Spurs | 104 |
| Post | 26, 2022 | Heat | 111 | Spurs | 102 |