| month | day | visitor | score | home | score |
|---|
| November | 2, 2021 | Pelicans | 125 | Heat | 108 |
| November | 5, 2021 | Spurs | 102 | Heat | 121 |
| November | 7, 2021 | Celtics | 131 | Heat | 110 |
| November | 9, 2021 | Heat | 114 | Pelicans | 129 |
| November | 10, 2021 | Kings | 92 | Heat | 102 |
| November | 12, 2021 | Rockets | 111 | Heat | 105 |
| November | 16, 2021 | Nets | 97 | Heat | 103 |
| November | 18, 2021 | Heat | 108 | Nets | 90 |
| November | 22, 2021 | Grizzlies | 126 | Heat | 114 |
| November | 23, 2021 | Lakers | 93 | Heat | 105 |
| November | 27, 2021 | Heat | 98 | Knicks | 100 |
| November | 28, 2021 | Knicks | 106 | Heat | 89 |
| December | 1, 2021 | Raptors | 115 | Heat | 111 |
| December | 2, 2021 | Heat | 94 | 76ers | 101 |
| December | 3, 2021 | Pelicans | 116 | Heat | 101 |
| December | 5, 2021 | 76ers | 103 | Heat | 129 |
| December | 9, 2021 | Hawks | 109 | Heat | 122 |
| December | 10, 2021 | Heat | 101 | Knicks | 119 |
| December | 14, 2021 | Heat | 78 | Nets | 102 |
| December | 16, 2021 | Heat | 107 | Sonics | 105 |
| December | 18, 2021 | Heat | 102 | Blazers | 122 |
| December | 21, 2021 | Bulls | 107 | Heat | 115 |
| December | 24, 2021 | Blazers | 104 | Heat | 102 |
| December | 26, 2021 | Heat | 103 | Hawks | 100 |
| December | 28, 2021 | Heat | 95 | 76ers | 105 |
| January | 2, 2022 | Heat | 130 | 76ers | 111 |
| January | 3, 2022 | Heat | 103 | Bucks | 115 |
| January | 6, 2022 | Heat | 118 | Lakers | 111 |
| January | 9, 2022 | Heat | 97 | Bulls | 104 |
| January | 10, 2022 | Celtics | 121 | Heat | 125 |
| January | 11, 2022 | Jazz | 113 | Heat | 100 |
| January | 12, 2022 | Heat | 93 | Rockets | 97 |
| January | 17, 2022 | Heat | 84 | Nets | 90 |
| January | 18, 2022 | Heat | 99 | Raptors | 128 |
| January | 19, 2022 | Heat | 120 | Clippers | 113 |
| January | 20, 2022 | Heat | 101 | Warriors | 129 |
| January | 21, 2022 | Bucks | 130 | Heat | 94 |
| January | 22, 2022 | Grizzlies | 106 | Heat | 97 |
| January | 26, 2022 | Heat | 96 | Knicks | 115 |
| February | 2, 2022 | Heat | | Celtics | |
| February | 4, 2022 | Heat | | Spurs | |
| February | 8, 2022 | Heat | | Mavericks | |
| February | 9, 2022 | Heat | | Pacers | |
| February | 10, 2022 | Clippers | | Heat | |
| February | 12, 2022 | Heat | | Kings | |
| February | 13, 2022 | Warriors | | Heat | |
| February | 15, 2022 | Heat | | Pacers | |
| February | 16, 2022 | Bucks | | Heat | |
| February | 18, 2022 | Heat | | Hawks | |
| February | 20, 2022 | Heat | | Bucks | |
| February | 23, 2022 | Pacers | | Heat | |
| February | 25, 2022 | Nuggets | | Heat | |
| February | 26, 2022 | Heat | | Pelicans | |
| February | 28, 2022 | Nets | | Heat | |
| March | 4, 2022 | Heat | | Suns | |
| March | 5, 2022 | Heat | | Jazz | |
| March | 7, 2022 | Hawks | | Heat | |
| March | 8, 2022 | Sonics | | Heat | |
| March | 14, 2022 | Heat | | Nets | |
| March | 18, 2022 | Hawks | | Heat | |
| March | 19, 2022 | Heat | | Celtics | |
| March | 20, 2022 | Heat | | Bulls | |
| March | 22, 2022 | Raptors | | Heat | |
| March | 26, 2022 | Heat | | Raptors | |
| March | 28, 2022 | Pelicans | | Heat | |
| March | 29, 2022 | Suns | | Heat | |
| April | 2, 2022 | 76ers | | Heat | |
| April | 4, 2022 | Bulls | | Heat | |
| April | 5, 2022 | Heat | | Wolves | |
| April | 6, 2022 | 76ers | | Heat | |
| April | 7, 2022 | Heat | | Knicks | |
| April | 8, 2022 | Heat | | Pelicans | |
| April | 10, 2022 | Celtics | | Heat | |
| April | 11, 2022 | Pacers | | Heat | |
| April | 12, 2022 | Heat | | Nuggets | |
| April | 14, 2022 | Heat | | Grizzlies | |
| April | 15, 2022 | Wolves | | Heat | |
| April | 18, 2022 | Celtics | | Heat | |
| April | 19, 2022 | Grizzlies | | Heat | |
| April | 20, 2022 | Heat | | Grizzlies | |
| April | 21, 2022 | Mavericks | | Heat | |
| April | 22, 2022 | Knicks | | Heat | |