| month | day | visitor | score | home | score |
|---|
| November | 2, 2021 | Celtics | 103 | Knicks | 124 |
| November | 5, 2021 | 76ers | 89 | Celtics | 115 |
| November | 6, 2021 | Celtics | 110 | Raptors | 120 |
| November | 7, 2021 | Celtics | 131 | Heat | 110 |
| November | 10, 2021 | Celtics | 112 | Nets | 106 |
| November | 13, 2021 | Grizzlies | 114 | Celtics | 124 |
| November | 14, 2021 | Raptors | 115 | Celtics | 149 |
| November | 18, 2021 | Rockets | 123 | Celtics | 105 |
| November | 22, 2021 | Kings | 97 | Celtics | 115 |
| November | 23, 2021 | Celtics | 108 | 76ers | 104 |
| November | 24, 2021 | Raptors | 110 | Celtics | 127 |
| November | 25, 2021 | Bulls | 108 | Celtics | 118 |
| November | 26, 2021 | Grizzlies | 101 | Celtics | 111 |
| November | 28, 2021 | Mavericks | 115 | Celtics | 105 |
| November | 29, 2021 | Bucks | 111 | Celtics | 107 |
| November | 30, 2021 | Celtics | 107 | Nets | 92 |
| December | 1, 2021 | Nets | 83 | Celtics | 114 |
| December | 8, 2021 | Celtics | 130 | Pelicans | 139 |
| December | 9, 2021 | Jazz | 100 | Celtics | 122 |
| December | 12, 2021 | Suns | 107 | Celtics | 124 |
| December | 13, 2021 | Nuggets | 134 | Celtics | 143 |
| December | 15, 2021 | Spurs | 96 | Celtics | 136 |
| December | 17, 2021 | Celtics | 101 | Bulls | 111 |
| December | 24, 2021 | Pelicans | 157 | Celtics | 129 |
| December | 26, 2021 | 76ers | 89 | Celtics | 126 |
| December | 28, 2021 | Knicks | 106 | Celtics | 126 |
| December | 31, 2021 | Lakers | 105 | Celtics | 126 |
| January | 1, 2022 | Grizzlies | 99 | Celtics | 109 |
| January | 2, 2022 | Celtics | 121 | Grizzlies | 120 |
| January | 4, 2022 | Wolves | 91 | Celtics | 116 |
| January | 5, 2022 | Pelicans | 115 | Celtics | 113 |
| January | 6, 2022 | 76ers | 99 | Celtics | 120 |
| January | 8, 2022 | Knicks | 99 | Celtics | 104 |
| January | 10, 2022 | Celtics | 121 | Heat | 125 |
| January | 22, 2022 | Celtics | 111 | 76ers | 86 |
| January | 24, 2022 | Celtics | 105 | Hawks | 113 |
| January | 27, 2022 | Celtics | 117 | Sonics | 96 |
| January | 28, 2022 | Celtics | 99 | Pacers | 109 |
| January | 30, 2022 | Celtics | 98 | Wolves | 92 |
| January | 31, 2022 | Celtics | 112 | Hawks | 104 |
| February | 2, 2022 | Heat | | Celtics | |
| February | 13, 2022 | Celtics | | Pelicans | |
| February | 17, 2022 | Celtics | | Warriors | |
| February | 19, 2022 | Celtics | | Raptors | |
| February | 21, 2022 | Celtics | | Jazz | |
| February | 22, 2022 | Nets | | Celtics | |
| February | 23, 2022 | Celtics | | Blazers | |
| February | 24, 2022 | Celtics | | Pelicans | |
| February | 25, 2022 | Celtics | | Lakers | |
| February | 26, 2022 | Clippers | | Celtics | |
| March | 1, 2022 | Bulls | | Celtics | |
| March | 2, 2022 | Hawks | | Celtics | |
| March | 3, 2022 | Warriors | | Celtics | |
| March | 4, 2022 | Celtics | | Knicks | |
| March | 7, 2022 | 76ers | | Celtics | |
| March | 9, 2022 | Celtics | | Bulls | |
| March | 10, 2022 | Bulls | | Celtics | |
| March | 12, 2022 | Bucks | | Celtics | |
| March | 16, 2022 | Pacers | | Celtics | |
| March | 17, 2022 | Celtics | | Knicks | |
| March | 18, 2022 | Celtics | | Knicks | |
| March | 19, 2022 | Heat | | Celtics | |
| March | 20, 2022 | Nets | | Celtics | |
| March | 21, 2022 | Celtics | | Spurs | |
| March | 22, 2022 | Celtics | | Nuggets | |
| March | 23, 2022 | Celtics | | Suns | |
| March | 25, 2022 | Celtics | | Pacers | |
| March | 26, 2022 | Pelicans | | Celtics | |
| March | 28, 2022 | Hawks | | Celtics | |
| March | 29, 2022 | Celtics | | Kings | |
| March | 30, 2022 | Celtics | | Bucks | |
| April | 6, 2022 | Sonics | | Celtics | |
| April | 7, 2022 | Celtics | | Clippers | |
| April | 10, 2022 | Celtics | | Heat | |
| April | 14, 2022 | Blazers | | Celtics | |
| April | 15, 2022 | Celtics | | Bucks | |
| April | 16, 2022 | Pacers | | Celtics | |
| April | 18, 2022 | Celtics | | Heat | |
| April | 20, 2022 | Celtics | | Nets | |
| April | 24, 2022 | Celtics | | Mavericks | |
| April | 25, 2022 | Celtics | | Grizzlies | |
| April | 26, 2022 | Celtics | | Rockets | |