| month | day | visitor | score | home | score |
|---|
| November | 9, 2020 | Rockets | 125 | Warriors | 130 |
| November | 11, 2020 | Sonics | 107 | Rockets | 110 |
| November | 12, 2020 | Rockets | 116 | Heat | 87 |
| November | 14, 2020 | Rockets | 109 | Suns | 105 |
| November | 15, 2020 | Rockets | 110 | Spurs | 128 |
| November | 16, 2020 | Wolves | 103 | Rockets | 109 |
| November | 18, 2020 | Rockets | 106 | Celtics | 91 |
| November | 20, 2020 | Rockets | 99 | Nuggets | 128 |
| November | 23, 2020 | Rockets | 95 | Wolves | 98 |
| November | 24, 2020 | Mavericks | 101 | Rockets | 95 |
| November | 26, 2020 | Rockets | 124 | Blazers | 112 |
| November | 27, 2020 | Raptors | 101 | Rockets | 107 |
| November | 29, 2020 | Rockets | 103 | Warriors | 112 |
| November | 30, 2020 | Jazz | 81 | Rockets | 90 |
| December | 1, 2020 | Rockets | 86 | Nuggets | 109 |
| December | 3, 2020 | Rockets | 78 | Lakers | 91 |
| December | 4, 2020 | Rockets | 90 | 76ers | 111 |
| December | 10, 2020 | Warriors | 115 | Rockets | 120 |
| December | 12, 2020 | Clippers | 120 | Rockets | 118 |
| December | 15, 2020 | Kings | 74 | Rockets | 86 |
| December | 17, 2020 | Spurs | 99 | Rockets | 124 |
| December | 19, 2020 | Rockets | 87 | Sonics | 121 |
| December | 21, 2020 | Kings | 87 | Rockets | 104 |
| December | 22, 2020 | Pacers | 103 | Rockets | 92 |
| December | 25, 2020 | Rockets | 79 | Suns | 104 |
| December | 26, 2020 | Suns | 106 | Rockets | 100 |
| December | 27, 2020 | Rockets | 77 | Jazz | 104 |
| December | 30, 2020 | Bulls | 103 | Rockets | 95 |
| December | 31, 2020 | Mavericks | 82 | Rockets | 110 |
| January | 1, 2021 | Clippers | 104 | Rockets | 113 |
| January | 2, 2021 | Rockets | 88 | Lakers | 90 |
| January | 3, 2021 | Nuggets | 92 | Rockets | 117 |
| January | 4, 2021 | Rockets | 92 | Suns | 131 |
| January | 6, 2021 | Hawks | 116 | Rockets | 101 |
| January | 8, 2021 | Suns | 94 | Rockets | 89 |
| January | 10, 2021 | Pelicans | 109 | Rockets | 104 |
| January | 12, 2021 | Heat | 89 | Rockets | 116 |
| January | 13, 2021 | Sonics | 109 | Rockets | 113 |
| January | 14, 2021 | Nuggets | 96 | Rockets | 85 |
| January | 15, 2021 | Mavericks | 78 | Rockets | 91 |
| January | 18, 2021 | Lakers | 71 | Rockets | 86 |
| January | 20, 2021 | Rockets | 74 | Pelicans | 102 |
| January | 22, 2021 | Rockets | 81 | Mavericks | 89 |
| January | 24, 2021 | Rockets | 108 | Kings | 115 |
| January | 25, 2021 | 76ers | 93 | Rockets | 103 |
| January | 26, 2021 | Rockets | 89 | Grizzlies | 97 |
| January | 29, 2021 | Rockets | 96 | Kings | 111 |
| February | 1, 2021 | Rockets | | Raptors | |
| February | 2, 2021 | Rockets | | Jazz | |
| February | 8, 2021 | Blazers | | Rockets | |
| February | 14, 2021 | Rockets | | Knicks | |
| February | 15, 2021 | Spurs | | Rockets | |
| February | 16, 2021 | Jazz | | Rockets | |
| February | 19, 2021 | Rockets | | Mavericks | |
| February | 20, 2021 | Lakers | | Rockets | |
| February | 26, 2021 | Rockets | | Wolves | |
| February | 27, 2021 | Jazz | | Rockets | |
| March | 3, 2021 | Rockets | | Bucks | |
| March | 4, 2021 | Rockets | | Hawks | |
| March | 5, 2021 | Rockets | | Sonics | |
| March | 6, 2021 | Rockets | | Spurs | |
| March | 8, 2021 | Grizzlies | | Rockets | |
| March | 9, 2021 | Rockets | | Blazers | |
| March | 10, 2021 | Nets | | Rockets | |
| March | 12, 2021 | Blazers | | Rockets | |
| March | 13, 2021 | Rockets | | Mavericks | |
| March | 14, 2021 | Wolves | | Rockets | |
| March | 16, 2021 | Suns | | Rockets | |
| March | 20, 2021 | Nuggets | | Rockets | |
| March | 22, 2021 | Warriors | | Rockets | |
| March | 25, 2021 | Knicks | | Rockets | |
| March | 27, 2021 | Rockets | | Bulls | |
| March | 28, 2021 | Rockets | | Nets | |
| March | 30, 2021 | Rockets | | Clippers | |
| March | 31, 2021 | Wolves | | Rockets | |
| April | 1, 2021 | Rockets | | Spurs | |
| April | 3, 2021 | Bucks | | Rockets | |
| April | 7, 2021 | Rockets | | Wolves | |
| April | 8, 2021 | Rockets | | Jazz | |
| April | 17, 2021 | Rockets | | Clippers | |
| April | 23, 2021 | Rockets | | Pacers | |
| April | 26, 2021 | Celtics | | Rockets | |