| month | day | visitor | score | home | score |
|---|
| November | 3, 2020 | Warriors | 105 | Lakers | 102 |
| November | 4, 2020 | Warriors | 105 | Lakers | 120 |
| November | 5, 2020 | Clippers | 103 | Lakers | 114 |
| November | 6, 2020 | Lakers | 119 | Hawks | 115 |
| November | 7, 2020 | Lakers | 95 | Jazz | 98 |
| November | 8, 2020 | Bulls | 80 | Lakers | 107 |
| November | 10, 2020 | Lakers | 92 | Clippers | 115 |
| November | 12, 2020 | Lakers | 113 | Nuggets | 115 |
| November | 13, 2020 | Lakers | 98 | Spurs | 121 |
| November | 14, 2020 | Lakers | 118 | Wolves | 116 |
| November | 15, 2020 | Kings | 99 | Lakers | 81 |
| November | 20, 2020 | Lakers | 105 | Bucks | 132 |
| November | 22, 2020 | Suns | 103 | Lakers | 126 |
| November | 23, 2020 | Lakers | 99 | Heat | 82 |
| November | 25, 2020 | Sonics | 108 | Lakers | 122 |
| November | 26, 2020 | Lakers | 105 | Warriors | 114 |
| December | 1, 2020 | Pelicans | 116 | Lakers | 111 |
| December | 3, 2020 | Rockets | 78 | Lakers | 91 |
| December | 5, 2020 | Lakers | 114 | Kings | 91 |
| December | 7, 2020 | Clippers | 98 | Lakers | 109 |
| December | 8, 2020 | Kings | 93 | Lakers | 111 |
| December | 12, 2020 | Lakers | 117 | Raptors | 130 |
| December | 14, 2020 | Lakers | 119 | Clippers | 126 |
| December | 15, 2020 | Grizzlies | 110 | Lakers | 108 |
| December | 19, 2020 | Jazz | 95 | Lakers | 122 |
| December | 21, 2020 | Sonics | 114 | Lakers | 117 |
| December | 23, 2020 | Knicks | 105 | Lakers | 103 |
| December | 24, 2020 | Clippers | 83 | Lakers | 115 |
| December | 25, 2020 | Lakers | 116 | Clippers | 104 |
| December | 29, 2020 | Lakers | 117 | Blazers | 129 |
| December | 31, 2020 | Lakers | 93 | Celtics | 89 |
| January | 2, 2021 | Rockets | 88 | Lakers | 90 |
| January | 5, 2021 | Lakers | 59 | Spurs | 89 |
| January | 6, 2021 | Heat | 94 | Lakers | 70 |
| January | 7, 2021 | Kings | 75 | Lakers | 82 |
| January | 8, 2021 | Lakers | 76 | Nets | 94 |
| January | 14, 2021 | Lakers | 86 | Mavericks | 90 |
| January | 15, 2021 | Lakers | 78 | Blazers | 104 |
| January | 16, 2021 | Raptors | 101 | Lakers | 74 |
| January | 18, 2021 | Lakers | 71 | Rockets | 86 |
| January | 20, 2021 | Lakers | 85 | Nuggets | 113 |
| January | 21, 2021 | Lakers | 67 | Kings | 87 |
| January | 23, 2021 | Lakers | 78 | Jazz | 102 |
| January | 31, 2021 | Lakers | 74 | Knicks | 90 |
| February | 1, 2021 | Sonics | | Lakers | |
| February | 8, 2021 | Nuggets | | Lakers | |
| February | 9, 2021 | 76ers | | Lakers | |
| February | 14, 2021 | Blazers | | Lakers | |
| February | 15, 2021 | Lakers | | Warriors | |
| February | 18, 2021 | Jazz | | Lakers | |
| February | 20, 2021 | Lakers | | Rockets | |
| February | 21, 2021 | Nets | | Lakers | |
| February | 22, 2021 | Lakers | | Suns | |
| February | 25, 2021 | Celtics | | Lakers | |
| February | 28, 2021 | Lakers | | Pelicans | |
| March | 1, 2021 | Lakers | | 76ers | |
| March | 2, 2021 | Wolves | | Lakers | |
| March | 3, 2021 | Lakers | | Grizzlies | |
| March | 6, 2021 | Mavericks | | Lakers | |
| March | 9, 2021 | Spurs | | Lakers | |
| March | 10, 2021 | Warriors | | Lakers | |
| March | 12, 2021 | Spurs | | Lakers | |
| March | 16, 2021 | Bucks | | Lakers | |
| March | 18, 2021 | Suns | | Lakers | |
| March | 19, 2021 | Nuggets | | Lakers | |
| March | 23, 2021 | Lakers | | Sonics | |
| March | 26, 2021 | Lakers | | Kings | |
| March | 27, 2021 | Wolves | | Lakers | |
| March | 28, 2021 | Lakers | | Blazers | |
| March | 31, 2021 | Pacers | | Lakers | |
| April | 2, 2021 | Lakers | | Mavericks | |
| April | 8, 2021 | Lakers | | Bulls | |
| April | 10, 2021 | Lakers | | Pacers | |
| April | 11, 2021 | Lakers | | Warriors | |
| April | 15, 2021 | Blazers | | Lakers | |
| April | 16, 2021 | Lakers | | Sonics | |
| April | 17, 2021 | Hawks | | Lakers | |
| April | 18, 2021 | Lakers | | Suns | |
| April | 21, 2021 | Lakers | | Wolves | |
| April | 22, 2021 | Lakers | | Sonics | |
| April | 23, 2021 | Mavericks | | Lakers | |
| April | 25, 2021 | Blazers | | Lakers | |