| month | day | visitor | score | home | score |
|---|
| November | 3, 2020 | Nuggets | 124 | Grizzlies | 106 |
| November | 6, 2020 | Grizzlies | 80 | Wolves | 108 |
| November | 11, 2020 | Warriors | 107 | Grizzlies | 111 |
| November | 13, 2020 | Grizzlies | 81 | Celtics | 93 |
| November | 17, 2020 | Grizzlies | 84 | Nets | 100 |
| November | 18, 2020 | Hawks | 104 | Grizzlies | 114 |
| November | 19, 2020 | Grizzlies | 91 | Spurs | 107 |
| November | 21, 2020 | Bulls | 79 | Grizzlies | 76 |
| November | 22, 2020 | Grizzlies | 77 | Heat | 81 |
| November | 23, 2020 | Pelicans | 120 | Grizzlies | 97 |
| November | 24, 2020 | Grizzlies | 86 | Knicks | 103 |
| November | 26, 2020 | Grizzlies | 91 | Celtics | 110 |
| November | 27, 2020 | Grizzlies | 107 | Pelicans | 114 |
| December | 5, 2020 | Nets | 90 | Grizzlies | 100 |
| December | 9, 2020 | Wolves | 128 | Grizzlies | 110 |
| December | 11, 2020 | Bulls | 91 | Grizzlies | 93 |
| December | 12, 2020 | Grizzlies | 103 | Pacers | 109 |
| December | 15, 2020 | Grizzlies | 110 | Lakers | 108 |
| December | 17, 2020 | Grizzlies | 105 | Suns | 92 |
| December | 18, 2020 | Raptors | 119 | Grizzlies | 90 |
| December | 23, 2020 | Grizzlies | 110 | Bucks | 115 |
| December | 24, 2020 | Grizzlies | 101 | Raptors | 114 |
| December | 25, 2020 | Grizzlies | 84 | 76ers | 90 |
| December | 28, 2020 | Grizzlies | 105 | Hawks | 109 |
| December | 30, 2020 | Grizzlies | 106 | Hawks | 105 |
| January | 1, 2021 | Grizzlies | 72 | Celtics | 99 |
| January | 2, 2021 | Celtics | 76 | Grizzlies | 93 |
| January | 3, 2021 | Jazz | 101 | Grizzlies | 95 |
| January | 4, 2021 | Grizzlies | 92 | 76ers | 87 |
| January | 10, 2021 | Grizzlies | 84 | Nets | 103 |
| January | 13, 2021 | Grizzlies | 88 | Pacers | 98 |
| January | 14, 2021 | Raptors | 113 | Grizzlies | 107 |
| January | 16, 2021 | Suns | 85 | Grizzlies | 90 |
| January | 19, 2021 | Grizzlies | 95 | Sonics | 116 |
| January | 22, 2021 | Grizzlies | 92 | Heat | 67 |
| January | 23, 2021 | Pacers | 94 | Grizzlies | 99 |
| January | 24, 2021 | Grizzlies | 87 | Knicks | 83 |
| January | 26, 2021 | Rockets | 89 | Grizzlies | 97 |
| January | 28, 2021 | Bulls | 93 | Grizzlies | 104 |
| January | 30, 2021 | Grizzlies | 88 | Knicks | 89 |
| February | 1, 2021 | Grizzlies | | Bucks | |
| February | 4, 2021 | Clippers | | Grizzlies | |
| February | 13, 2021 | 76ers | | Grizzlies | |
| February | 14, 2021 | Grizzlies | | Raptors | |
| February | 17, 2021 | Mavericks | | Grizzlies | |
| February | 18, 2021 | Bucks | | Grizzlies | |
| February | 19, 2021 | Bulls | | Grizzlies | |
| February | 20, 2021 | Grizzlies | | Bulls | |
| February | 21, 2021 | Grizzlies | | Pacers | |
| February | 24, 2021 | Bucks | | Grizzlies | |
| February | 25, 2021 | Bucks | | Grizzlies | |
| February | 26, 2021 | Bucks | | Grizzlies | |
| March | 3, 2021 | Lakers | | Grizzlies | |
| March | 5, 2021 | 76ers | | Grizzlies | |
| March | 8, 2021 | Grizzlies | | Rockets | |
| March | 9, 2021 | Kings | | Grizzlies | |
| March | 11, 2021 | Hawks | | Grizzlies | |
| March | 13, 2021 | Pelicans | | Grizzlies | |
| March | 14, 2021 | Raptors | | Grizzlies | |
| March | 16, 2021 | Grizzlies | | Bulls | |
| March | 18, 2021 | Grizzlies | | Raptors | |
| March | 20, 2021 | Sonics | | Grizzlies | |
| March | 21, 2021 | Grizzlies | | Nuggets | |
| March | 23, 2021 | Grizzlies | | Clippers | |
| March | 24, 2021 | Pelicans | | Grizzlies | |
| March | 26, 2021 | Grizzlies | | Jazz | |
| March | 29, 2021 | Spurs | | Grizzlies | |
| March | 30, 2021 | Grizzlies | | Nets | |
| April | 6, 2021 | Grizzlies | | Blazers | |
| April | 7, 2021 | Pacers | | Grizzlies | |
| April | 12, 2021 | Grizzlies | | Mavericks | |
| April | 13, 2021 | Blazers | | Grizzlies | |
| April | 14, 2021 | Heat | | Grizzlies | |
| April | 16, 2021 | Grizzlies | | Hawks | |
| April | 17, 2021 | Nets | | Grizzlies | |
| April | 18, 2021 | Grizzlies | | Kings | |
| April | 19, 2021 | Grizzlies | | Heat | |
| April | 20, 2021 | Heat | | Grizzlies | |
| April | 22, 2021 | Grizzlies | | Warriors | |
| April | 23, 2021 | Knicks | | Grizzlies | |
| April | 25, 2021 | Celtics | | Grizzlies | |
| April | 26, 2021 | Knicks | | Grizzlies | |