| month | day | visitor | score | home | score |
|---|
| November | 2, 2027 | Grizzlies | 90 | Pelicans | 106 |
| November | 8, 2027 | Grizzlies | 84 | Heat | 80 |
| November | 14, 2027 | 76ers | 72 | Grizzlies | 84 |
| November | 15, 2027 | Pelicans | 94 | Grizzlies | 86 |
| November | 16, 2027 | Grizzlies | 98 | Pacers | 74 |
| November | 17, 2027 | Grizzlies | 88 | Nets | 90 |
| November | 18, 2027 | Heat | 91 | Grizzlies | 105 |
| November | 19, 2027 | Grizzlies | 113 | Celtics | 93 |
| November | 20, 2027 | Grizzlies | 123 | Knicks | 105 |
| November | 21, 2027 | Grizzlies | 84 | 76ers | 90 |
| November | 22, 2027 | Grizzlies | 93 | Mavericks | 92 |
| December | 1, 2027 | Grizzlies | 109 | Heat | 99 |
| December | 2, 2027 | Sonics | 80 | Grizzlies | 102 |
| December | 8, 2027 | Wolves | 94 | Grizzlies | 106 |
| December | 10, 2027 | Nuggets | 82 | Grizzlies | 97 |
| December | 11, 2027 | Grizzlies | 77 | Sonics | 90 |
| December | 14, 2027 | Celtics | 102 | Grizzlies | 106 |
| December | 16, 2027 | Bucks | 78 | Grizzlies | 96 |
| December | 18, 2027 | Lakers | 85 | Grizzlies | 108 |
| December | 20, 2027 | Grizzlies | 91 | Wolves | 109 |
| December | 22, 2027 | Grizzlies | 100 | Bucks | 103 |
| December | 24, 2027 | Grizzlies | 80 | Pelicans | 82 |
| December | 27, 2027 | Nets | 81 | Grizzlies | 103 |
| December | 28, 2027 | Grizzlies | 104 | Kings | 98 |
| December | 31, 2027 | Knicks | 105 | Grizzlies | 121 |
| January | 2, 2028 | Grizzlies | 115 | Nets | 90 |
| January | 6, 2028 | Grizzlies | 102 | Pelicans | 100 |
| January | 7, 2028 | Grizzlies | 122 | Spurs | 102 |
| January | 9, 2028 | Grizzlies | 114 | Warriors | 108 |
| January | 10, 2028 | Grizzlies | 114 | Knicks | 107 |
| January | 11, 2028 | Nets | 103 | Grizzlies | 115 |
| January | 12, 2028 | Celtics | 92 | Grizzlies | 110 |
| January | 13, 2028 | Pacers | 100 | Grizzlies | 111 |
| January | 18, 2028 | Nets | 80 | Grizzlies | 115 |
| January | 21, 2028 | Pelicans | 100 | Grizzlies | 89 |
| January | 22, 2028 | Warriors | 75 | Grizzlies | 97 |
| January | 23, 2028 | Nets | 94 | Grizzlies | 102 |
| January | 24, 2028 | Spurs | 97 | Grizzlies | 137 |
| January | 25, 2028 | Pelicans | 77 | Grizzlies | 105 |
| January | 27, 2028 | Grizzlies | 112 | Celtics | 83 |
| January | 29, 2028 | Kings | 102 | Grizzlies | 117 |
| January | 31, 2028 | Bulls | 89 | Grizzlies | 95 |
| February | 7, 2028 | Celtics | | Grizzlies | |
| February | 9, 2028 | Grizzlies | | 76ers | |
| February | 10, 2028 | Grizzlies | | Clippers | |
| February | 11, 2028 | Jazz | | Grizzlies | |
| February | 14, 2028 | Bucks | | Grizzlies | |
| February | 19, 2028 | Grizzlies | | Heat | |
| February | 23, 2028 | Grizzlies | | Knicks | |
| February | 25, 2028 | Knicks | | Grizzlies | |
| February | 27, 2028 | Grizzlies | | Rockets | |
| March | 1, 2028 | Pelicans | | Grizzlies | |
| March | 3, 2028 | Raptors | | Grizzlies | |
| March | 6, 2028 | 76ers | | Grizzlies | |
| March | 11, 2028 | Grizzlies | | Raptors | |
| March | 12, 2028 | Grizzlies | | Suns | |
| March | 16, 2028 | Pacers | | Grizzlies | |
| March | 25, 2028 | Bulls | | Grizzlies | |
| March | 30, 2028 | Grizzlies | | 76ers | |
| April | 1, 2028 | Knicks | | Grizzlies | |
| April | 2, 2028 | Rockets | | Grizzlies | |
| April | 3, 2028 | Heat | | Grizzlies | |
| April | 4, 2028 | Grizzlies | | Pacers | |
| April | 5, 2028 | Knicks | | Grizzlies | |
| April | 8, 2028 | Grizzlies | | Jazz | |
| April | 9, 2028 | Grizzlies | | Celtics | |
| April | 16, 2028 | Grizzlies | | Heat | |
| April | 18, 2028 | Grizzlies | | Bulls | |
| April | 21, 2028 | Grizzlies | | Bucks | |
| April | 22, 2028 | 76ers | | Grizzlies | |
| April | 23, 2028 | Grizzlies | | Nets | |
| April | 24, 2028 | Grizzlies | | 76ers | |
| April | 27, 2028 | Grizzlies | | Lakers | |
| April | 29, 2028 | Mavericks | | Grizzlies | |
| April | 30, 2028 | Grizzlies | | Raptors | |
| May | 3, 2028 | Heat | | Grizzlies | |
| May | 4, 2028 | Suns | | Grizzlies | |
| May | 8, 2028 | Clippers | | Grizzlies | |
| May | 9, 2028 | Grizzlies | | Bulls | |
| May | 10, 2028 | Raptors | | Grizzlies | |
| May | 12, 2028 | Grizzlies | | Nuggets | |
| May | 14, 2028 | Grizzlies | | Celtics | |