| month | day | visitor | score | home | score |
|---|
| November | 4, 2022 | Knicks | 115 | Spurs | 111 |
| November | 5, 2022 | Spurs | 102 | Heat | 109 |
| November | 10, 2022 | Spurs | 102 | Wolves | 104 |
| November | 13, 2022 | Lakers | 119 | Spurs | 124 |
| November | 15, 2022 | Rockets | 107 | Spurs | 78 |
| November | 18, 2022 | Spurs | 72 | Mavericks | 115 |
| November | 19, 2022 | Grizzlies | 102 | Spurs | 91 |
| November | 22, 2022 | Jazz | 110 | Spurs | 94 |
| November | 27, 2022 | Jazz | 93 | Spurs | 94 |
| November | 29, 2022 | Suns | 104 | Spurs | 118 |
| December | 5, 2022 | Jazz | 106 | Spurs | 105 |
| December | 6, 2022 | Spurs | 86 | Clippers | 115 |
| December | 7, 2022 | Bucks | 87 | Spurs | 96 |
| December | 8, 2022 | Wolves | 101 | Spurs | 87 |
| December | 10, 2022 | Nuggets | 109 | Spurs | 106 |
| December | 11, 2022 | Warriors | 91 | Spurs | 113 |
| December | 13, 2022 | Hawks | 117 | Spurs | 102 |
| December | 15, 2022 | Spurs | 113 | Celtics | 128 |
| December | 17, 2022 | Spurs | 72 | Rockets | 98 |
| December | 20, 2022 | Spurs | 100 | Mavericks | 108 |
| December | 21, 2022 | Spurs | 116 | Pelicans | 125 |
| December | 22, 2022 | Mavericks | 110 | Spurs | 112 |
| December | 23, 2022 | Pacers | 95 | Spurs | 103 |
| December | 31, 2022 | Kings | 103 | Spurs | 96 |
| January | 1, 2023 | Blazers | 91 | Spurs | 93 |
| January | 2, 2023 | Nets | 113 | Spurs | 101 |
| January | 3, 2023 | Spurs | 93 | Kings | 141 |
| January | 5, 2023 | Lakers | 107 | Spurs | 93 |
| January | 7, 2023 | Spurs | 81 | Sonics | 106 |
| January | 8, 2023 | Sonics | 135 | Spurs | 104 |
| January | 9, 2023 | Spurs | 125 | Clippers | 114 |
| January | 11, 2023 | Clippers | 120 | Spurs | 121 |
| January | 14, 2023 | Spurs | 80 | Wolves | 89 |
| January | 17, 2023 | Spurs | 102 | Mavericks | 107 |
| January | 20, 2023 | Mavericks | 105 | Spurs | 81 |
| January | 21, 2023 | Clippers | 118 | Spurs | 125 |
| January | 25, 2023 | Spurs | 90 | Bulls | 93 |
| January | 27, 2023 | Spurs | 98 | Jazz | 128 |
| January | 28, 2023 | Blazers | 103 | Spurs | 94 |
| January | 29, 2023 | Spurs | 96 | Bucks | 101 |
| February | 1, 2023 | Kings | 107 | Spurs | 109 |
| February | 2, 2023 | Spurs | 96 | Nuggets | 130 |
| February | 4, 2023 | Heat | 94 | Spurs | 97 |
| February | 9, 2023 | Spurs | 101 | Jazz | 119 |
| February | 11, 2023 | Pelicans | 115 | Spurs | 95 |
| February | 12, 2023 | Warriors | 99 | Spurs | 114 |
| February | 13, 2023 | Spurs | 80 | Kings | 121 |
| February | 15, 2023 | Spurs | 81 | Rockets | 96 |
| February | 16, 2023 | Bulls | 112 | Spurs | 88 |
| February | 21, 2023 | Spurs | 130 | Nuggets | 129 |
| February | 24, 2023 | Wolves | 105 | Spurs | 100 |
| February | 26, 2023 | Spurs | 107 | Hawks | 122 |
| February | 28, 2023 | 76ers | 90 | Spurs | 105 |
| March | 2, 2023 | Spurs | 80 | Knicks | 98 |
| March | 3, 2023 | Spurs | 99 | Sonics | 131 |
| March | 4, 2023 | Spurs | 84 | Nuggets | 105 |
| March | 6, 2023 | Rockets | 104 | Spurs | 101 |
| March | 8, 2023 | Spurs | 85 | Suns | 97 |
| March | 9, 2023 | Spurs | 93 | Lakers | 101 |
| March | 11, 2023 | Sonics | 84 | Spurs | 96 |
| March | 12, 2023 | Spurs | 96 | Lakers | 88 |
| March | 15, 2023 | Mavericks | 80 | Spurs | 101 |
| March | 21, 2023 | Celtics | 75 | Spurs | 83 |
| March | 23, 2023 | Spurs | 81 | Warriors | 84 |
| March | 27, 2023 | Spurs | 99 | Nets | 111 |
| March | 29, 2023 | Spurs | 70 | Grizzlies | 106 |
| March | 30, 2023 | Spurs | 83 | Suns | 100 |
| April | 1, 2023 | Rockets | 82 | Spurs | 75 |
| April | 3, 2023 | Spurs | 88 | Wolves | 103 |
| April | 4, 2023 | Raptors | 103 | Spurs | 106 |
| April | 7, 2023 | Suns | 98 | Spurs | 116 |
| April | 8, 2023 | Spurs | 79 | 76ers | 99 |
| April | 9, 2023 | Spurs | 106 | Warriors | 85 |
| April | 10, 2023 | Nuggets | 115 | Spurs | 100 |
| April | 11, 2023 | Spurs | 83 | Blazers | 104 |
| April | 12, 2023 | Spurs | 92 | Jazz | 118 |
| April | 13, 2023 | Wolves | 103 | Spurs | 99 |
| April | 14, 2023 | Spurs | 103 | Raptors | 104 |
| April | 16, 2023 | Spurs | 100 | Suns | 89 |
| April | 22, 2023 | Spurs | 84 | Blazers | 80 |
| April | 24, 2023 | Spurs | 86 | Pacers | 114 |
| April | 25, 2023 | Nuggets | 93 | Spurs | 91 |