| month | day | visitor | score | home | score |
|---|
| November | 2, 2021 | Pelicans | 117 | Heat | 123 |
| November | 5, 2021 | Spurs | 111 | Heat | 100 |
| November | 7, 2021 | Celtics | 135 | Heat | 102 |
| November | 9, 2021 | Heat | 114 | Pelicans | 100 |
| November | 10, 2021 | Kings | 106 | Heat | 88 |
| November | 12, 2021 | Rockets | 95 | Heat | 97 |
| November | 16, 2021 | Nets | 116 | Heat | 99 |
| November | 18, 2021 | Heat | 77 | Nets | 99 |
| November | 22, 2021 | Grizzlies | 83 | Heat | 120 |
| November | 23, 2021 | Lakers | 100 | Heat | 109 |
| November | 27, 2021 | Heat | 105 | Knicks | 99 |
| November | 28, 2021 | Knicks | 113 | Heat | 104 |
| December | 1, 2021 | Raptors | 119 | Heat | 101 |
| December | 2, 2021 | Heat | 80 | 76ers | 101 |
| December | 3, 2021 | Pelicans | 102 | Heat | 87 |
| December | 5, 2021 | 76ers | 123 | Heat | 86 |
| December | 9, 2021 | Hawks | 101 | Heat | 112 |
| December | 10, 2021 | Heat | 94 | Knicks | 89 |
| December | 14, 2021 | Heat | 81 | Nets | 96 |
| December | 16, 2021 | Heat | 111 | Sonics | 108 |
| December | 18, 2021 | Heat | 83 | Blazers | 113 |
| December | 21, 2021 | Bulls | 110 | Heat | 125 |
| December | 24, 2021 | Blazers | 94 | Heat | 110 |
| December | 26, 2021 | Heat | 112 | Hawks | 109 |
| December | 28, 2021 | Heat | 91 | 76ers | 81 |
| January | 2, 2022 | Heat | 97 | 76ers | 100 |
| January | 3, 2022 | Heat | 114 | Bucks | 130 |
| January | 6, 2022 | Heat | 112 | Lakers | 123 |
| January | 9, 2022 | Heat | 111 | Bulls | 128 |
| January | 10, 2022 | Celtics | 119 | Heat | 130 |
| January | 11, 2022 | Jazz | 112 | Heat | 120 |
| January | 12, 2022 | Heat | 85 | Rockets | 124 |
| January | 17, 2022 | Heat | 100 | Nets | 107 |
| January | 18, 2022 | Heat | 115 | Raptors | 125 |
| January | 19, 2022 | Heat | 116 | Clippers | 118 |
| January | 20, 2022 | Heat | 89 | Warriors | 122 |
| January | 21, 2022 | Bucks | 126 | Heat | 135 |
| January | 22, 2022 | Grizzlies | 107 | Heat | 108 |
| January | 26, 2022 | Heat | 91 | Knicks | 112 |
| February | 2, 2022 | Heat | 121 | Celtics | 116 |
| February | 4, 2022 | Heat | 91 | Spurs | 99 |
| February | 8, 2022 | Heat | 101 | Mavericks | 104 |
| February | 9, 2022 | Heat | 97 | Pacers | 91 |
| February | 10, 2022 | Clippers | 106 | Heat | 121 |
| February | 12, 2022 | Heat | 96 | Kings | 95 |
| February | 13, 2022 | Warriors | 86 | Heat | 97 |
| February | 15, 2022 | Heat | 97 | Pacers | 107 |
| February | 16, 2022 | Bucks | 107 | Heat | 102 |
| February | 18, 2022 | Heat | 122 | Hawks | 139 |
| February | 20, 2022 | Heat | 98 | Bucks | 127 |
| February | 23, 2022 | Pacers | 103 | Heat | 136 |
| February | 25, 2022 | Nuggets | 114 | Heat | 92 |
| February | 26, 2022 | Heat | 104 | Pelicans | 110 |
| February | 28, 2022 | Nets | 96 | Heat | 100 |
| March | 4, 2022 | Heat | 88 | Suns | 100 |
| March | 5, 2022 | Heat | 124 | Jazz | 98 |
| March | 7, 2022 | Hawks | 106 | Heat | 100 |
| March | 8, 2022 | Sonics | 73 | Heat | 102 |
| March | 14, 2022 | Heat | 90 | Nets | 87 |
| March | 18, 2022 | Hawks | 103 | Heat | 106 |
| March | 19, 2022 | Heat | 117 | Celtics | 108 |
| March | 20, 2022 | Heat | 97 | Bulls | 114 |
| March | 22, 2022 | Raptors | 122 | Heat | 109 |
| March | 26, 2022 | Heat | 107 | Raptors | 110 |
| March | 28, 2022 | Pelicans | 95 | Heat | 109 |
| March | 29, 2022 | Suns | 105 | Heat | 91 |
| April | 2, 2022 | 76ers | 94 | Heat | 101 |
| April | 4, 2022 | Bulls | 117 | Heat | 111 |
| April | 5, 2022 | Heat | 98 | Wolves | 111 |
| April | 6, 2022 | 76ers | 90 | Heat | 102 |
| April | 7, 2022 | Heat | 87 | Knicks | 92 |
| April | 8, 2022 | Heat | 94 | Pelicans | 98 |
| April | 10, 2022 | Celtics | 109 | Heat | 102 |
| April | 11, 2022 | Pacers | 97 | Heat | 102 |
| April | 12, 2022 | Heat | 92 | Nuggets | 111 |
| April | 14, 2022 | Heat | 105 | Grizzlies | 108 |
| April | 15, 2022 | Wolves | 103 | Heat | 91 |
| April | 18, 2022 | Celtics | 119 | Heat | 109 |
| April | 19, 2022 | Grizzlies | 96 | Heat | 103 |
| April | 20, 2022 | Heat | 98 | Grizzlies | 116 |
| April | 21, 2022 | Mavericks | 92 | Heat | 83 |
| April | 22, 2022 | Knicks | 110 | Heat | 103 |