| month | day | visitor | score | home | score |
|---|
| November | 3, 2020 | Knicks | 99 | 76ers | 102 |
| November | 4, 2020 | 76ers | 107 | Bucks | 109 |
| November | 5, 2020 | 76ers | 78 | Celtics | 91 |
| November | 6, 2020 | Blazers | 144 | 76ers | 126 |
| November | 7, 2020 | 76ers | 93 | Knicks | 108 |
| November | 9, 2020 | Bulls | 79 | 76ers | 98 |
| November | 14, 2020 | 76ers | 98 | Bulls | 95 |
| November | 18, 2020 | Bucks | 74 | 76ers | 72 |
| November | 22, 2020 | 76ers | 69 | Pacers | 93 |
| November | 23, 2020 | Celtics | 95 | 76ers | 74 |
| November | 24, 2020 | 76ers | 70 | Nets | 104 |
| November | 27, 2020 | 76ers | 73 | Kings | 106 |
| November | 29, 2020 | Pacers | 85 | 76ers | 84 |
| December | 2, 2020 | Heat | 107 | 76ers | 72 |
| December | 3, 2020 | 76ers | 74 | Nuggets | 110 |
| December | 4, 2020 | Rockets | 126 | 76ers | 82 |
| December | 5, 2020 | 76ers | 70 | Heat | 105 |
| December | 7, 2020 | Warriors | 114 | 76ers | 98 |
| December | 12, 2020 | 76ers | 70 | Knicks | 103 |
| December | 13, 2020 | 76ers | 74 | Nets | 102 |
| December | 17, 2020 | 76ers | 109 | Bucks | 129 |
| December | 18, 2020 | Pelicans | 115 | 76ers | 116 |
| December | 20, 2020 | Hawks | 100 | 76ers | 110 |
| December | 21, 2020 | Raptors | 96 | 76ers | 103 |
| December | 23, 2020 | 76ers | 122 | Pelicans | 130 |
| December | 25, 2020 | Grizzlies | 105 | 76ers | 127 |
| December | 26, 2020 | 76ers | 107 | Celtics | 128 |
| December | 27, 2020 | 76ers | 119 | Suns | 117 |
| December | 28, 2020 | Heat | 69 | 76ers | 100 |
| December | 30, 2020 | 76ers | 89 | Knicks | 92 |
| January | 2, 2021 | Heat | 79 | 76ers | 105 |
| January | 4, 2021 | Grizzlies | 106 | 76ers | 123 |
| January | 6, 2021 | 76ers | 82 | Celtics | 101 |
| January | 7, 2021 | Mavericks | 86 | 76ers | 95 |
| January | 8, 2021 | 76ers | 102 | Wolves | 101 |
| January | 13, 2021 | 76ers | 83 | Nets | 110 |
| January | 14, 2021 | Bucks | 124 | 76ers | 120 |
| January | 15, 2021 | Kings | 102 | 76ers | 100 |
| January | 17, 2021 | Jazz | 89 | 76ers | 84 |
| January | 19, 2021 | 76ers | 106 | Warriors | 101 |
| January | 22, 2021 | Celtics | 107 | 76ers | 101 |
| January | 23, 2021 | Wolves | 114 | 76ers | 106 |
| January | 25, 2021 | 76ers | 89 | Rockets | 111 |
| January | 29, 2021 | Knicks | 97 | 76ers | 103 |
| January | 30, 2021 | 76ers | 118 | Bulls | 114 |
| January | 31, 2021 | 76ers | 83 | Sonics | 134 |
| February | 8, 2021 | 76ers | 83 | Raptors | 123 |
| February | 9, 2021 | 76ers | 95 | Lakers | 125 |
| February | 10, 2021 | 76ers | 111 | Blazers | 108 |
| February | 11, 2021 | Raptors | 118 | 76ers | 96 |
| February | 12, 2021 | 76ers | 120 | Clippers | 118 |
| February | 13, 2021 | 76ers | 88 | Grizzlies | 81 |
| February | 14, 2021 | Pelicans | 110 | 76ers | 122 |
| February | 15, 2021 | Nets | 108 | 76ers | 100 |
| February | 17, 2021 | 76ers | 106 | Hawks | 102 |
| February | 19, 2021 | Knicks | 106 | 76ers | 111 |
| February | 20, 2021 | 76ers | 92 | Mavericks | 81 |
| February | 23, 2021 | Clippers | 118 | 76ers | 104 |
| February | 26, 2021 | Nets | 102 | 76ers | 95 |
| February | 28, 2021 | 76ers | 106 | Spurs | 96 |
| March | 1, 2021 | Lakers | 135 | 76ers | 86 |
| March | 5, 2021 | 76ers | 99 | Grizzlies | 98 |
| March | 7, 2021 | 76ers | 95 | Celtics | 111 |
| March | 10, 2021 | Hawks | 127 | 76ers | 117 |
| March | 11, 2021 | 76ers | 100 | Jazz | 109 |
| March | 12, 2021 | 76ers | 91 | Pelicans | 121 |
| March | 14, 2021 | 76ers | 100 | Hawks | 109 |
| March | 16, 2021 | Raptors | 106 | 76ers | 98 |
| March | 21, 2021 | Bulls | 111 | 76ers | 88 |
| March | 27, 2021 | Pelicans | 126 | 76ers | 130 |
| March | 29, 2021 | 76ers | 90 | Pacers | 129 |
| March | 30, 2021 | Sonics | 106 | 76ers | 113 |
| March | 31, 2021 | 76ers | 98 | Raptors | 112 |
| April | 2, 2021 | 76ers | 77 | Heat | 89 |
| April | 6, 2021 | 76ers | 86 | Heat | 90 |
| April | 8, 2021 | Spurs | 107 | 76ers | 108 |
| April | 9, 2021 | Bulls | 95 | 76ers | 101 |
| April | 12, 2021 | Pacers | 121 | 76ers | 86 |
| April | 13, 2021 | 76ers | 88 | Pelicans | 132 |
| April | 16, 2021 | Nuggets | 106 | 76ers | 83 |
| April | 18, 2021 | Nets | 101 | 76ers | 98 |
| April | 19, 2021 | Suns | 115 | 76ers | 104 |