| month | day | visitor | score | home | score |
|---|
| November | 3, 2021 | Knicks | 90 | 76ers | 100 |
| November | 4, 2021 | 76ers | 117 | Bucks | 136 |
| November | 5, 2021 | 76ers | 128 | Celtics | 138 |
| November | 6, 2021 | Blazers | 97 | 76ers | 82 |
| November | 7, 2021 | 76ers | 86 | Knicks | 119 |
| November | 9, 2021 | Bulls | 119 | 76ers | 106 |
| November | 14, 2021 | 76ers | 118 | Bulls | 122 |
| November | 18, 2021 | Bucks | 120 | 76ers | 114 |
| November | 22, 2021 | 76ers | 109 | Pacers | 103 |
| November | 23, 2021 | Celtics | 112 | 76ers | 102 |
| November | 24, 2021 | 76ers | 71 | Nets | 116 |
| November | 27, 2021 | 76ers | 88 | Kings | 123 |
| November | 29, 2021 | Pacers | 100 | 76ers | 93 |
| December | 2, 2021 | Heat | 80 | 76ers | 101 |
| December | 3, 2021 | 76ers | 118 | Nuggets | 114 |
| December | 4, 2021 | Rockets | 96 | 76ers | 77 |
| December | 5, 2021 | 76ers | 123 | Heat | 86 |
| December | 7, 2021 | Warriors | 90 | 76ers | 118 |
| December | 12, 2021 | 76ers | 101 | Knicks | 100 |
| December | 13, 2021 | 76ers | 101 | Nets | 113 |
| December | 17, 2021 | 76ers | 99 | Bucks | 119 |
| December | 18, 2021 | Pelicans | 133 | 76ers | 112 |
| December | 20, 2021 | Hawks | 93 | 76ers | 87 |
| December | 21, 2021 | Raptors | 118 | 76ers | 103 |
| December | 23, 2021 | 76ers | 82 | Pelicans | 121 |
| December | 25, 2021 | Grizzlies | 104 | 76ers | 95 |
| December | 26, 2021 | 76ers | 89 | Celtics | 111 |
| December | 27, 2021 | 76ers | 91 | Suns | 108 |
| December | 28, 2021 | Heat | 91 | 76ers | 81 |
| December | 30, 2021 | 76ers | 90 | Knicks | 115 |
| January | 2, 2022 | Heat | 97 | 76ers | 100 |
| January | 4, 2022 | Grizzlies | 112 | 76ers | 76 |
| January | 6, 2022 | 76ers | 112 | Celtics | 120 |
| January | 7, 2022 | Mavericks | 116 | 76ers | 115 |
| January | 8, 2022 | 76ers | 88 | Wolves | 111 |
| January | 13, 2022 | 76ers | 92 | Nets | 100 |
| January | 14, 2022 | Bucks | 118 | 76ers | 128 |
| January | 15, 2022 | Kings | 78 | 76ers | 77 |
| January | 17, 2022 | Jazz | 119 | 76ers | 83 |
| January | 19, 2022 | 76ers | 93 | Warriors | 102 |
| January | 22, 2022 | Celtics | 101 | 76ers | 89 |
| January | 23, 2022 | Wolves | 115 | 76ers | 94 |
| January | 25, 2022 | 76ers | 77 | Rockets | 113 |
| January | 29, 2022 | Knicks | 108 | 76ers | 94 |
| January | 30, 2022 | 76ers | 80 | Bulls | 106 |
| January | 31, 2022 | 76ers | 75 | Sonics | 85 |
| February | 8, 2022 | 76ers | 117 | Raptors | 111 |
| February | 9, 2022 | 76ers | 87 | Lakers | 102 |
| February | 10, 2022 | 76ers | 88 | Blazers | 98 |
| February | 11, 2022 | Raptors | 114 | 76ers | 115 |
| February | 12, 2022 | 76ers | 97 | Clippers | 121 |
| February | 13, 2022 | 76ers | 94 | Grizzlies | 117 |
| February | 14, 2022 | Pelicans | 107 | 76ers | 77 |
| February | 15, 2022 | Nets | 114 | 76ers | 93 |
| February | 17, 2022 | 76ers | 107 | Hawks | 136 |
| February | 19, 2022 | Knicks | 122 | 76ers | 100 |
| February | 20, 2022 | 76ers | 100 | Mavericks | 104 |
| February | 23, 2022 | Clippers | 116 | 76ers | 100 |
| February | 26, 2022 | Nets | 109 | 76ers | 77 |
| February | 28, 2022 | 76ers | 83 | Spurs | 101 |
| March | 1, 2022 | Lakers | 98 | 76ers | 96 |
| March | 5, 2022 | 76ers | 111 | Grizzlies | 100 |
| March | 7, 2022 | 76ers | 82 | Celtics | 121 |
| March | 10, 2022 | Hawks | 131 | 76ers | 125 |
| March | 11, 2022 | 76ers | 93 | Jazz | 109 |
| March | 12, 2022 | 76ers | 97 | Pelicans | 109 |
| March | 14, 2022 | 76ers | 100 | Hawks | 138 |
| March | 16, 2022 | Raptors | 105 | 76ers | 112 |
| March | 21, 2022 | Bulls | 107 | 76ers | 83 |
| March | 27, 2022 | Pelicans | 89 | 76ers | 79 |
| March | 29, 2022 | 76ers | 115 | Pacers | 113 |
| March | 30, 2022 | Sonics | 82 | 76ers | 97 |
| March | 31, 2022 | 76ers | 91 | Raptors | 88 |
| April | 2, 2022 | 76ers | 94 | Heat | 101 |
| April | 6, 2022 | 76ers | 90 | Heat | 102 |
| April | 8, 2022 | Spurs | 93 | 76ers | 76 |
| April | 9, 2022 | Bulls | 129 | 76ers | 85 |
| April | 12, 2022 | Pacers | 109 | 76ers | 101 |
| April | 13, 2022 | 76ers | 89 | Pelicans | 98 |
| April | 16, 2022 | Nuggets | 107 | 76ers | 114 |
| April | 18, 2022 | Nets | 94 | 76ers | 85 |
| April | 19, 2022 | Suns | 93 | 76ers | 100 |