| month | day | visitor | score | home | score |
|---|
| November | 2, 2021 | Sonics | 92 | Lakers | 103 |
| November | 4, 2021 | Lakers | 90 | Sonics | 99 |
| November | 5, 2021 | Sonics | 125 | Suns | 106 |
| November | 7, 2021 | Kings | 94 | Sonics | 81 |
| November | 10, 2021 | Sonics | 90 | Jazz | 97 |
| November | 12, 2021 | Sonics | 106 | Pelicans | 115 |
| November | 14, 2021 | Sonics | 113 | Clippers | 115 |
| November | 15, 2021 | Sonics | 108 | Suns | 115 |
| November | 17, 2021 | Mavericks | 77 | Sonics | 94 |
| November | 20, 2021 | Rockets | 92 | Sonics | 110 |
| November | 22, 2021 | Pelicans | 121 | Sonics | 102 |
| November | 23, 2021 | Suns | 112 | Sonics | 101 |
| November | 25, 2021 | Sonics | 119 | Mavericks | 82 |
| November | 26, 2021 | Sonics | 78 | Warriors | 96 |
| December | 1, 2021 | Sonics | 91 | Warriors | 107 |
| December | 2, 2021 | Sonics | 98 | Rockets | 86 |
| December | 3, 2021 | Sonics | 105 | Nuggets | 143 |
| December | 5, 2021 | Grizzlies | 98 | Sonics | 112 |
| December | 7, 2021 | Sonics | 91 | Spurs | 111 |
| December | 8, 2021 | Jazz | 95 | Sonics | 110 |
| December | 14, 2021 | Nuggets | 110 | Sonics | 122 |
| December | 15, 2021 | Warriors | 90 | Sonics | 101 |
| December | 16, 2021 | Spurs | 98 | Sonics | 100 |
| December | 25, 2021 | Clippers | 102 | Sonics | 89 |
| December | 26, 2021 | Sonics | 66 | Kings | 107 |
| January | 2, 2022 | Wolves | 104 | Sonics | 95 |
| January | 4, 2022 | Sonics | 104 | Wolves | 106 |
| January | 6, 2022 | Kings | 113 | Sonics | 106 |
| January | 8, 2022 | Lakers | 103 | Sonics | 98 |
| January | 9, 2022 | Sonics | 103 | Blazers | 96 |
| January | 10, 2022 | Sonics | 100 | Grizzlies | 87 |
| January | 11, 2022 | Blazers | 88 | Sonics | 109 |