| month | day | visitor | score | home | score |
|---|
| November | 3, 2021 | Pelicans | 93 | Mavericks | 75 |
| November | 5, 2021 | Mavericks | 66 | Pelicans | 92 |
| November | 8, 2021 | Suns | 90 | Pelicans | 126 |
| November | 10, 2021 | Pelicans | 104 | Lakers | 109 |
| November | 12, 2021 | Sonics | 106 | Pelicans | 115 |
| November | 17, 2021 | Pelicans | 108 | Wolves | 94 |
| November | 19, 2021 | Pelicans | 100 | Nuggets | 110 |
| November | 20, 2021 | Pelicans | 112 | Suns | 103 |
| November | 22, 2021 | Pelicans | 121 | Sonics | 102 |
| November | 26, 2021 | Pelicans | 87 | Kings | 83 |
| November | 27, 2021 | Pelicans | 112 | Grizzlies | 103 |
| November | 28, 2021 | Warriors | 81 | Pelicans | 86 |
| December | 1, 2021 | Pelicans | 83 | Clippers | 101 |
| December | 2, 2021 | Pelicans | 67 | Jazz | 114 |
| December | 4, 2021 | Jazz | 83 | Pelicans | 103 |
| December | 6, 2021 | Clippers | 111 | Pelicans | 81 |
| December | 7, 2021 | Pelicans | 89 | Grizzlies | 115 |
| December | 8, 2021 | Kings | 93 | Pelicans | 114 |
| December | 15, 2021 | Mavericks | 76 | Pelicans | 91 |
| December | 20, 2021 | Pelicans | 82 | Warriors | 88 |
| December | 21, 2021 | Pelicans | 85 | Spurs | 93 |
| December | 22, 2021 | Wolves | 84 | Pelicans | 95 |
| December | 24, 2021 | Pelicans | 76 | Jazz | 79 |
| December | 29, 2021 | Grizzlies | 89 | Pelicans | 100 |
| December | 31, 2021 | Nuggets | 112 | Pelicans | 127 |
| January | 1, 2022 | Rockets | 87 | Pelicans | 84 |
| January | 3, 2022 | Nuggets | 111 | Pelicans | 116 |
| January | 7, 2022 | Blazers | 106 | Pelicans | 102 |
| January | 9, 2022 | Lakers | 86 | Pelicans | 104 |
| January | 11, 2022 | Pelicans | 91 | Rockets | 85 |
| January | 12, 2022 | Pelicans | 85 | Blazers | 103 |
| January | 13, 2022 | Spurs | 96 | Pelicans | 89 |