| month | day | visitor | score | home | score |
|---|
| November | 3, 2021 | Pelicans | 93 | Mavericks | 75 |
| November | 5, 2021 | Mavericks | 66 | Pelicans | 92 |
| November | 9, 2021 | Lakers | 94 | Mavericks | 88 |
| November | 10, 2021 | Mavericks | 74 | Rockets | 89 |
| November | 11, 2021 | Warriors | 85 | Mavericks | 68 |
| November | 13, 2021 | Mavericks | 76 | Spurs | 75 |
| November | 15, 2021 | Mavericks | 81 | Jazz | 90 |
| November | 17, 2021 | Mavericks | 77 | Sonics | 94 |
| November | 18, 2021 | Jazz | 85 | Mavericks | 90 |
| November | 21, 2021 | Mavericks | 70 | Warriors | 77 |
| November | 25, 2021 | Sonics | 119 | Mavericks | 82 |
| November | 26, 2021 | Mavericks | 90 | Wolves | 109 |
| November | 27, 2021 | Mavericks | 79 | Nuggets | 93 |
| November | 30, 2021 | Suns | 85 | Mavericks | 83 |
| December | 3, 2021 | Spurs | 87 | Mavericks | 85 |
| December | 5, 2021 | Clippers | 86 | Mavericks | 78 |
| December | 6, 2021 | Grizzlies | 81 | Mavericks | 79 |
| December | 7, 2021 | Jazz | 75 | Mavericks | 76 |
| December | 15, 2021 | Mavericks | 76 | Pelicans | 91 |
| December | 16, 2021 | Mavericks | 108 | Clippers | 105 |
| December | 20, 2021 | Mavericks | 91 | Kings | 95 |
| December | 21, 2021 | Mavericks | 93 | Nuggets | 102 |
| December | 25, 2021 | Mavericks | 79 | Grizzlies | 84 |
| December | 28, 2021 | Blazers | 85 | Mavericks | 79 |
| December | 30, 2021 | Kings | 100 | Mavericks | 98 |
| December | 31, 2021 | Grizzlies | 94 | Mavericks | 89 |
| January | 1, 2022 | Mavericks | 71 | Lakers | 68 |
| January | 3, 2022 | Rockets | 73 | Mavericks | 82 |
| January | 5, 2022 | Mavericks | 75 | Blazers | 101 |
| January | 7, 2022 | Wolves | 79 | Mavericks | 83 |
| January | 8, 2022 | Mavericks | 93 | Suns | 84 |
| January | 10, 2022 | Nuggets | 103 | Mavericks | 94 |