| month | day | visitor | score | home | score |
|---|
| November | 2, 2021 | Sonics | 92 | Lakers | 103 |
| November | 4, 2021 | Lakers | 90 | Sonics | 99 |
| November | 9, 2021 | Lakers | 94 | Mavericks | 88 |
| November | 10, 2021 | Pelicans | 104 | Lakers | 109 |
| November | 14, 2021 | Lakers | 97 | Warriors | 92 |
| November | 15, 2021 | Warriors | 82 | Lakers | 86 |
| November | 16, 2021 | Lakers | 85 | Rockets | 88 |
| November | 17, 2021 | Clippers | 100 | Lakers | 125 |
| November | 18, 2021 | Grizzlies | 67 | Lakers | 119 |
| November | 19, 2021 | Kings | 71 | Lakers | 106 |
| November | 21, 2021 | Kings | 83 | Lakers | 102 |
| November | 22, 2021 | Lakers | 64 | Jazz | 80 |
| November | 23, 2021 | Spurs | 82 | Lakers | 114 |
| November | 24, 2021 | Lakers | 90 | Clippers | 116 |
| November | 25, 2021 | Blazers | 76 | Lakers | 106 |
| November | 28, 2021 | Lakers | 98 | Spurs | 89 |
| November | 29, 2021 | Lakers | 123 | Nuggets | 127 |
| December | 5, 2021 | Rockets | 78 | Lakers | 85 |
| December | 15, 2021 | Lakers | 77 | Blazers | 90 |
| December | 18, 2021 | Wolves | 66 | Lakers | 80 |
| December | 19, 2021 | Lakers | 77 | Wolves | 70 |
| December | 22, 2021 | Jazz | 55 | Lakers | 82 |
| December | 23, 2021 | Suns | 91 | Lakers | 89 |
| December | 24, 2021 | Lakers | 76 | Suns | 106 |
| December | 25, 2021 | Lakers | 73 | Kings | 92 |
| December | 26, 2021 | Lakers | 93 | Grizzlies | 84 |
| December | 27, 2021 | Lakers | 103 | Suns | 107 |
| January | 1, 2022 | Mavericks | 71 | Lakers | 68 |
| January | 2, 2022 | Warriors | 103 | Lakers | 65 |
| January | 5, 2022 | Nuggets | 95 | Lakers | 110 |
| January | 8, 2022 | Lakers | 103 | Sonics | 98 |
| January | 9, 2022 | Lakers | 86 | Pelicans | 104 |