| month | day | visitor | score | home | score |
|---|
| November | 4, 2021 | 76ers | 91 | Knicks | 102 |
| November | 7, 2021 | Knicks | 111 | Nets | 98 |
| November | 9, 2021 | Hawks | 80 | Knicks | 100 |
| November | 11, 2021 | Knicks | 80 | Bulls | 86 |
| November | 12, 2021 | Celtics | 77 | Knicks | 70 |
| November | 13, 2021 | Knicks | 101 | Magic | 87 |
| November | 15, 2021 | Magic | 101 | Knicks | 87 |
| November | 16, 2021 | Hornets | 84 | Knicks | 76 |
| November | 20, 2021 | Knicks | 71 | Heat | 76 |
| November | 22, 2021 | Knicks | 94 | Bucks | 100 |
| November | 23, 2021 | Knicks | 106 | Raptors | 116 |
| November | 25, 2021 | Knicks | 104 | Hornets | 73 |
| November | 27, 2021 | Heat | 101 | Knicks | 91 |
| November | 28, 2021 | Knicks | 97 | 76ers | 93 |
| December | 1, 2021 | Raptors | 103 | Knicks | 111 |
| December | 2, 2021 | Wizards | 78 | Knicks | 88 |
| December | 4, 2021 | Nets | 90 | Knicks | 93 |
| December | 5, 2021 | Bulls | 93 | Knicks | 82 |
| December | 6, 2021 | Pacers | 62 | Knicks | 114 |
| December | 13, 2021 | Knicks | 92 | Magic | 94 |
| December | 15, 2021 | Cavaliers | 77 | Knicks | 104 |
| December | 16, 2021 | Knicks | 92 | Hawks | 94 |
| December | 21, 2021 | Knicks | 99 | Pacers | 77 |
| December | 22, 2021 | Bucks | 84 | Knicks | 86 |
| December | 23, 2021 | Knicks | 94 | Celtics | 77 |
| December | 26, 2021 | Knicks | 93 | 76ers | 58 |
| December | 30, 2021 | Heat | 78 | Knicks | 85 |
| January | 1, 2022 | Knicks | 103 | Pistons | 79 |
| January | 5, 2022 | Knicks | 80 | Wizards | 87 |
| January | 6, 2022 | Pistons | 60 | Knicks | 93 |
| January | 8, 2022 | Celtics | 87 | Knicks | 85 |
| January | 11, 2022 | Knicks | 83 | Cavaliers | 95 |