| month | day | visitor | score | home | score |
|---|
| November | 2, 2021 | Bucks | 79 | Hornets | 94 |
| November | 5, 2021 | Hornets | 80 | Pacers | 70 |
| November | 7, 2021 | Cavaliers | 73 | Hornets | 86 |
| November | 8, 2021 | Raptors | 89 | Hornets | 96 |
| November | 9, 2021 | Hornets | 82 | Nets | 95 |
| November | 11, 2021 | Hornets | 107 | Raptors | 91 |
| November | 12, 2021 | Hornets | 84 | 76ers | 92 |
| November | 14, 2021 | Hornets | 85 | Heat | 81 |
| November | 15, 2021 | Pistons | 90 | Hornets | 98 |
| November | 16, 2021 | Hornets | 84 | Knicks | 76 |
| November | 18, 2021 | Hornets | 74 | Bucks | 91 |
| November | 22, 2021 | Hornets | 80 | Hawks | 88 |
| November | 23, 2021 | Heat | 83 | Hornets | 89 |
| November | 24, 2021 | Nets | 99 | Hornets | 82 |
| November | 25, 2021 | Knicks | 104 | Hornets | 73 |
| November | 29, 2021 | Hornets | 109 | Pacers | 75 |
| December | 1, 2021 | Hornets | 76 | Wizards | 78 |
| December | 2, 2021 | Celtics | 57 | Hornets | 85 |
| December | 3, 2021 | Hornets | 87 | Hawks | 86 |
| December | 7, 2021 | 76ers | 98 | Hornets | 97 |
| December | 9, 2021 | Pacers | 67 | Hornets | 87 |
| December | 13, 2021 | Hornets | 105 | Celtics | 82 |
| December | 16, 2021 | Bulls | 84 | Hornets | 80 |
| December | 20, 2021 | Wizards | 57 | Hornets | 96 |
| December | 26, 2021 | Hornets | 94 | Pistons | 71 |
| December | 27, 2021 | Magic | 64 | Hornets | 106 |
| December | 28, 2021 | Pistons | 75 | Hornets | 104 |
| December | 29, 2021 | Hornets | 96 | Bulls | 99 |
| January | 3, 2022 | Hornets | 90 | Magic | 71 |
| January | 10, 2022 | Hornets | 91 | Cavaliers | 75 |
| January | 11, 2022 | Raptors | 108 | Hornets | 118 |
| January | 13, 2022 | Hawks | 98 | Hornets | 106 |