| month | day | visitor | score | home | score |
|---|
| November | 2, 2021 | Heat | 67 | Celtics | 81 |
| November | 3, 2021 | Heat | 77 | Nets | 83 |
| November | 5, 2021 | Cavaliers | 56 | Heat | 89 |
| November | 6, 2021 | Heat | 82 | Hawks | 63 |
| November | 11, 2021 | Heat | 98 | Pistons | 56 |
| November | 14, 2021 | Hornets | 85 | Heat | 81 |
| November | 15, 2021 | Heat | 85 | Pacers | 63 |
| November | 20, 2021 | Knicks | 71 | Heat | 76 |
| November | 21, 2021 | Heat | 74 | Magic | 80 |
| November | 23, 2021 | Heat | 83 | Hornets | 89 |
| November | 27, 2021 | Heat | 101 | Knicks | 91 |
| November | 29, 2021 | Bulls | 88 | Heat | 85 |
| November | 30, 2021 | Heat | 84 | Bucks | 78 |
| December | 1, 2021 | 76ers | 80 | Heat | 89 |
| December | 4, 2021 | Pistons | 74 | Heat | 99 |
| December | 6, 2021 | Heat | 60 | Cavaliers | 74 |
| December | 8, 2021 | Magic | 76 | Heat | 73 |
| December | 20, 2021 | Pacers | 61 | Heat | 90 |
| December | 22, 2021 | 76ers | 69 | Heat | 96 |
| December | 26, 2021 | Hawks | 99 | Heat | 79 |
| December | 27, 2021 | Nets | 100 | Heat | 77 |
| December | 28, 2021 | Heat | 93 | 76ers | 64 |
| December | 29, 2021 | Heat | 89 | Wizards | 80 |
| December | 30, 2021 | Heat | 78 | Knicks | 85 |
| December | 31, 2021 | Wizards | 65 | Heat | 75 |
| January | 2, 2022 | Bucks | 51 | Heat | 94 |
| January | 5, 2022 | Celtics | 63 | Heat | 90 |
| January | 6, 2022 | Heat | 86 | Raptors | 80 |
| January | 7, 2022 | Raptors | 95 | Heat | 111 |
| January | 9, 2022 | Heat | 81 | Magic | 82 |
| January | 11, 2022 | Celtics | 59 | Heat | 92 |
| January | 12, 2022 | Heat | 84 | Bulls | 87 |