| month | day | visitor | score | home | score |
|---|
| November | 2, 2021 | Clippers | 106 | Wolves | 96 |
| November | 4, 2021 | Suns | 82 | Clippers | 113 |
| November | 5, 2021 | Spurs | 101 | Clippers | 111 |
| November | 7, 2021 | Clippers | 107 | Rockets | 86 |
| November | 9, 2021 | Jazz | 95 | Clippers | 93 |
| November | 14, 2021 | Sonics | 113 | Clippers | 115 |
| November | 16, 2021 | Warriors | 97 | Clippers | 81 |
| November | 17, 2021 | Clippers | 100 | Lakers | 125 |
| November | 20, 2021 | Blazers | 103 | Clippers | 91 |
| November | 21, 2021 | Rockets | 69 | Clippers | 87 |
| November | 24, 2021 | Lakers | 90 | Clippers | 116 |
| November | 25, 2021 | Nuggets | 102 | Clippers | 108 |
| November | 26, 2021 | Blazers | 88 | Clippers | 92 |
| November | 27, 2021 | Clippers | 102 | Spurs | 94 |
| December | 1, 2021 | Pelicans | 83 | Clippers | 101 |
| December | 5, 2021 | Clippers | 86 | Mavericks | 78 |
| December | 6, 2021 | Clippers | 111 | Pelicans | 81 |
| December | 7, 2021 | Kings | 103 | Clippers | 106 |
| December | 8, 2021 | Clippers | 105 | Suns | 118 |
| December | 16, 2021 | Mavericks | 108 | Clippers | 105 |
| December | 17, 2021 | Clippers | 95 | Spurs | 113 |
| December | 18, 2021 | Grizzlies | 85 | Clippers | 139 |
| December | 19, 2021 | Clippers | 110 | Grizzlies | 113 |
| December | 25, 2021 | Clippers | 102 | Sonics | 89 |
| December | 27, 2021 | Clippers | 80 | Warriors | 99 |
| December | 29, 2021 | Clippers | 97 | Rockets | 77 |
| December | 30, 2021 | Clippers | 84 | Blazers | 106 |
| January | 1, 2022 | Clippers | 90 | Kings | 102 |
| January | 6, 2022 | Wolves | 89 | Clippers | 116 |
| January | 11, 2022 | Clippers | 99 | Jazz | 102 |
| January | 12, 2022 | Clippers | 117 | Nuggets | 127 |
| January | 13, 2022 | Wolves | 113 | Clippers | 108 |