| month | day | visitor | score | home | score |
|---|
| November | 2, 2021 | Bulls | 69 | Wizards | 86 |
| November | 4, 2021 | Bulls | 82 | Pistons | 81 |
| November | 6, 2021 | Celtics | 84 | Bulls | 61 |
| November | 8, 2021 | Cavaliers | 71 | Bulls | 85 |
| November | 9, 2021 | Pacers | 60 | Bulls | 97 |
| November | 11, 2021 | Knicks | 80 | Bulls | 86 |
| November | 12, 2021 | Bulls | 66 | Cavaliers | 77 |
| November | 13, 2021 | Raptors | 81 | Bulls | 85 |
| November | 16, 2021 | Wizards | 83 | Bulls | 94 |
| November | 17, 2021 | Bulls | 87 | Pacers | 69 |
| November | 18, 2021 | Bulls | 78 | Nets | 75 |
| November | 19, 2021 | Bucks | 79 | Bulls | 70 |
| November | 22, 2021 | Wizards | 94 | Bulls | 68 |
| November | 24, 2021 | Bulls | 106 | Bucks | 101 |
| November | 27, 2021 | Hawks | 72 | Bulls | 98 |
| November | 29, 2021 | Bulls | 88 | Heat | 85 |
| November | 30, 2021 | Bulls | 93 | Cavaliers | 92 |
| December | 4, 2021 | Magic | 83 | Bulls | 86 |
| December | 5, 2021 | Bulls | 93 | Knicks | 82 |
| December | 13, 2021 | Pistons | 61 | Bulls | 95 |
| December | 16, 2021 | Bulls | 84 | Hornets | 80 |
| December | 19, 2021 | Bulls | 79 | Nets | 75 |
| December | 20, 2021 | Bulls | 94 | Hawks | 104 |
| December | 22, 2021 | Bulls | 93 | Magic | 70 |
| December | 24, 2021 | 76ers | 71 | Bulls | 81 |
| December | 26, 2021 | Bulls | 93 | Celtics | 77 |
| December | 28, 2021 | Bulls | 112 | Raptors | 93 |
| December | 29, 2021 | Hornets | 96 | Bulls | 99 |
| January | 4, 2022 | Bucks | 71 | Bulls | 91 |
| January | 5, 2022 | Nets | 70 | Bulls | 91 |
| January | 8, 2022 | Bulls | 77 | 76ers | 65 |
| January | 12, 2022 | Heat | 84 | Bulls | 87 |