| month | day | visitor | score | home | score |
|---|
| November | 6, 2021 | Blazers | 83 | Wolves | 80 |
| November | 7, 2021 | Blazers | 79 | Warriors | 106 |
| November | 11, 2021 | Wolves | 73 | Blazers | 78 |
| November | 16, 2021 | Wolves | 75 | Blazers | 94 |
| November | 18, 2021 | Kings | 76 | Blazers | 87 |
| November | 19, 2021 | Blazers | 104 | Grizzlies | 83 |
| November | 20, 2021 | Blazers | 103 | Clippers | 91 |
| November | 24, 2021 | Blazers | 111 | Nuggets | 94 |
| November | 25, 2021 | Blazers | 76 | Lakers | 106 |
| November | 26, 2021 | Blazers | 88 | Clippers | 92 |
| November | 28, 2021 | Nuggets | 113 | Blazers | 104 |
| December | 3, 2021 | Grizzlies | 77 | Blazers | 119 |
| December | 6, 2021 | Spurs | 102 | Blazers | 80 |
| December | 8, 2021 | Rockets | 78 | Blazers | 76 |
| December | 14, 2021 | Jazz | 76 | Blazers | 65 |
| December | 15, 2021 | Lakers | 77 | Blazers | 90 |
| December | 18, 2021 | Blazers | 79 | Spurs | 73 |
| December | 19, 2021 | Spurs | 67 | Blazers | 93 |
| December | 23, 2021 | Warriors | 86 | Blazers | 84 |
| December | 28, 2021 | Blazers | 85 | Mavericks | 79 |
| December | 30, 2021 | Clippers | 84 | Blazers | 106 |
| December | 31, 2021 | Blazers | 77 | Rockets | 76 |
| January | 1, 2022 | Blazers | 86 | Suns | 111 |
| January | 3, 2022 | Blazers | 89 | Kings | 98 |
| January | 4, 2022 | Blazers | 92 | Jazz | 81 |
| January | 5, 2022 | Mavericks | 75 | Blazers | 101 |
| January | 7, 2022 | Blazers | 106 | Pelicans | 102 |
| January | 9, 2022 | Sonics | 103 | Blazers | 96 |
| January | 10, 2022 | Blazers | 96 | Rockets | 76 |
| January | 11, 2022 | Blazers | 88 | Sonics | 109 |
| January | 12, 2022 | Pelicans | 85 | Blazers | 103 |
| January | 13, 2022 | Suns | 85 | Blazers | 92 |