| month | day | visitor | score | home | score |
|---|
| November | 4, 2020 | Pistons | 72 | Grizzlies | 77 |
| November | 5, 2020 | Bobcats | 71 | Pistons | 76 |
| November | 6, 2020 | Pistons | 76 | Raptors | 94 |
| November | 7, 2020 | Pistons | 88 | 76ers | 85 |
| November | 10, 2020 | Knicks | 104 | Pistons | 100 |
| November | 11, 2020 | Bulls | 78 | Pistons | 66 |
| November | 12, 2020 | Pistons | 71 | Celtics | 97 |
| November | 15, 2020 | Pistons | 77 | Kings | 113 |
| November | 17, 2020 | Magic | 74 | Pistons | 79 |
| November | 18, 2020 | Cavaliers | 87 | Pistons | 92 |
| November | 19, 2020 | Heat | 103 | Pistons | 91 |
| November | 21, 2020 | Pacers | 71 | Pistons | 63 |
| November | 22, 2020 | Pistons | 70 | Bulls | 93 |
| November | 23, 2020 | Nets | 83 | Pistons | 84 |
| November | 28, 2020 | Pistons | 81 | Cavaliers | 91 |
| December | 3, 2020 | Pistons | 79 | 76ers | 65 |
| December | 5, 2020 | Pistons | 58 | Magic | 81 |
| December | 6, 2020 | Pistons | 73 | Pacers | 78 |
| December | 7, 2020 | Pistons | 90 | Rockets | 92 |
| December | 8, 2020 | Knicks | 91 | Pistons | 94 |
| December | 9, 2020 | Pistons | 80 | Bucks | 73 |
| December | 12, 2020 | Wizards | 82 | Pistons | 79 |
| December | 13, 2020 | Pistons | 73 | Cavaliers | 71 |
| December | 14, 2020 | Pacers | 76 | Pistons | 89 |
| December | 16, 2020 | Grizzlies | 80 | Pistons | 83 |
| December | 19, 2020 | Magic | 85 | Pistons | 68 |
| December | 21, 2020 | Bulls | 98 | Pistons | 83 |
| December | 22, 2020 | 76ers | 69 | Pistons | 73 |
| December | 24, 2020 | Rockets | 70 | Pistons | 88 |
| December | 26, 2020 | Pistons | 85 | Nuggets | 108 |
| December | 28, 2020 | Nets | 91 | Pistons | 77 |
| January | 1, 2021 | Warriors | 72 | Pistons | 75 |
| January | 6, 2021 | Pistons | 86 | Pelicans | 99 |
| January | 7, 2021 | Pistons | 73 | Mavericks | 63 |
| January | 9, 2021 | Bucks | 75 | Pistons | 79 |
| January | 17, 2021 | Wolves | 87 | Pistons | 74 |
| January | 20, 2021 | Pistons | 83 | Sonics | 79 |
| January | 22, 2021 | Pistons | 67 | Nets | 91 |
| January | 23, 2021 | Kings | 83 | Pistons | 109 |
| January | 25, 2021 | Hawks | 86 | Pistons | 82 |
| January | 26, 2021 | Pistons | 67 | Wizards | 90 |
| January | 27, 2021 | Mavericks | 70 | Pistons | 71 |
| January | 28, 2021 | Pistons | 87 | Bucks | 99 |
| January | 31, 2021 | Pistons | 65 | Warriors | 90 |
| February | 2, 2021 | Raptors | 81 | Pistons | 91 |
| February | 5, 2021 | Pistons | 68 | Bobcats | 81 |
| February | 6, 2021 | Pistons | 68 | Clippers | 92 |
| February | 7, 2021 | Heat | 80 | Pistons | 84 |
| February | 12, 2021 | Pistons | 70 | Celtics | 83 |
| February | 13, 2021 | Spurs | 77 | Pistons | 85 |
| February | 21, 2021 | Celtics | 81 | Pistons | 92 |
| February | 23, 2021 | Blazers | 80 | Pistons | 83 |
| February | 27, 2021 | Celtics | 104 | Pistons | 77 |
| February | 28, 2021 | Bucks | 80 | Pistons | 62 |
| March | 4, 2021 | Pistons | 68 | Heat | 85 |
| March | 6, 2021 | Pistons | 60 | Wolves | 84 |
| March | 9, 2021 | Pistons | 83 | Hawks | 86 |
| March | 10, 2021 | Wizards | 93 | Pistons | 82 |
| March | 11, 2021 | Pistons | 87 | Suns | 96 |
| March | 12, 2021 | Cavaliers | 79 | Pistons | 77 |
| March | 13, 2021 | 76ers | 71 | Pistons | 75 |
| March | 15, 2021 | Lakers | 80 | Pistons | 69 |
| March | 16, 2021 | Pistons | 86 | Raptors | 97 |
| March | 18, 2021 | Pistons | 110 | Knicks | 111 |
| March | 19, 2021 | Suns | 90 | Pistons | 78 |
| March | 20, 2021 | Pistons | 71 | Jazz | 86 |
| March | 21, 2021 | Pistons | 87 | Lakers | 85 |
| March | 24, 2021 | Pistons | 73 | Magic | 81 |
| March | 25, 2021 | Clippers | 97 | Pistons | 76 |
| March | 27, 2021 | Pistons | 84 | Knicks | 112 |
| March | 30, 2021 | Pistons | 75 | Nets | 86 |
| April | 5, 2021 | Hawks | 72 | Pistons | 68 |
| April | 9, 2021 | Nuggets | 84 | Pistons | 86 |
| April | 10, 2021 | Sonics | 85 | Pistons | 100 |
| April | 11, 2021 | Jazz | 97 | Pistons | 90 |
| April | 12, 2021 | Pistons | 55 | Bulls | 105 |
| April | 13, 2021 | Pelicans | 113 | Pistons | 78 |
| April | 15, 2021 | Pistons | 70 | Wizards | 84 |
| April | 19, 2021 | Pistons | 73 | Blazers | 83 |
| April | 22, 2021 | Pistons | 63 | Heat | 81 |
| April | 27, 2021 | Pistons | 60 | Spurs | 83 |
| April | 29, 2021 | Pistons | 51 | Bobcats | 84 |