| month | day | visitor | score | home | score |
|---|
| November | 3, 2020 | 76ers | 87 | Lakers | 106 |
| November | 6, 2020 | Lakers | 87 | Pelicans | 130 |
| November | 8, 2020 | Lakers | 94 | Wizards | 99 |
| November | 9, 2020 | Lakers | 87 | Blazers | 104 |
| November | 13, 2020 | Lakers | 83 | Clippers | 111 |
| November | 14, 2020 | Celtics | 108 | Lakers | 77 |
| November | 15, 2020 | Lakers | 69 | Bulls | 94 |
| November | 16, 2020 | Lakers | 89 | Pacers | 78 |
| November | 17, 2020 | Lakers | 111 | Raptors | 93 |
| November | 21, 2020 | Lakers | 110 | Pelicans | 122 |
| November | 22, 2020 | Hawks | 71 | Lakers | 96 |
| November | 23, 2020 | Lakers | 105 | Nuggets | 106 |
| November | 24, 2020 | Lakers | 79 | Jazz | 78 |
| December | 1, 2020 | Bulls | 109 | Lakers | 74 |
| December | 2, 2020 | Lakers | 96 | Celtics | 110 |
| December | 4, 2020 | Lakers | 119 | Sonics | 107 |
| December | 9, 2020 | Wolves | 111 | Lakers | 103 |
| December | 10, 2020 | Lakers | 106 | Wolves | 98 |
| December | 11, 2020 | Pelicans | 116 | Lakers | 110 |
| December | 12, 2020 | Knicks | 108 | Lakers | 100 |
| December | 17, 2020 | Mavericks | 76 | Lakers | 104 |
| December | 18, 2020 | Kings | 114 | Lakers | 134 |
| December | 19, 2020 | Grizzlies | 97 | Lakers | 127 |
| December | 24, 2020 | Sonics | 105 | Lakers | 127 |
| December | 25, 2020 | Lakers | 78 | Warriors | 89 |
| December | 27, 2020 | Jazz | 93 | Lakers | 92 |
| December | 31, 2020 | Lakers | 116 | Suns | 92 |
| January | 4, 2021 | Lakers | 102 | Wolves | 95 |
| January | 5, 2021 | Nuggets | 97 | Lakers | 153 |
| January | 9, 2021 | Warriors | 82 | Lakers | 111 |
| January | 10, 2021 | Blazers | 98 | Lakers | 103 |
| January | 11, 2021 | Lakers | 98 | Grizzlies | 67 |
| January | 12, 2021 | Lakers | 120 | Sonics | 109 |
| January | 15, 2021 | Lakers | 93 | Mavericks | 88 |
| January | 17, 2021 | Warriors | 90 | Lakers | 68 |
| January | 19, 2021 | Bucks | 111 | Lakers | 104 |
| January | 21, 2021 | Grizzlies | 68 | Lakers | 83 |
| January | 28, 2021 | Blazers | 105 | Lakers | 102 |
| February | 2, 2021 | Rockets | 93 | Lakers | 98 |
| February | 5, 2021 | Wizards | 81 | Lakers | 112 |
| February | 6, 2021 | Lakers | 102 | Spurs | 86 |
| February | 15, 2021 | Nets | 82 | Lakers | 106 |
| February | 16, 2021 | Spurs | 96 | Lakers | 103 |
| February | 18, 2021 | Lakers | 98 | Bucks | 112 |
| February | 19, 2021 | Lakers | 99 | Cavaliers | 93 |
| February | 22, 2021 | Clippers | 114 | Lakers | 104 |
| February | 23, 2021 | Lakers | 96 | 76ers | 77 |
| February | 24, 2021 | Kings | 99 | Lakers | 115 |
| February | 28, 2021 | Nuggets | 113 | Lakers | 120 |
| March | 5, 2021 | Lakers | 99 | Magic | 104 |
| March | 7, 2021 | Heat | 87 | Lakers | 96 |
| March | 9, 2021 | Pelicans | 108 | Lakers | 90 |
| March | 11, 2021 | Mavericks | 76 | Lakers | 99 |
| March | 12, 2021 | Lakers | 95 | Mavericks | 70 |
| March | 14, 2021 | Lakers | 94 | Heat | 102 |
| March | 15, 2021 | Lakers | 80 | Pistons | 69 |
| March | 16, 2021 | Lakers | 99 | Jazz | 102 |
| March | 21, 2021 | Pistons | 87 | Lakers | 85 |
| March | 22, 2021 | Lakers | 103 | Nuggets | 98 |
| March | 23, 2021 | Magic | 102 | Lakers | 110 |
| March | 26, 2021 | Lakers | 91 | Nets | 98 |
| March | 31, 2021 | Lakers | 106 | Suns | 109 |
| April | 4, 2021 | Spurs | 94 | Lakers | 96 |
| April | 5, 2021 | Wolves | 87 | Lakers | 98 |
| April | 7, 2021 | Lakers | 67 | Rockets | 94 |
| April | 8, 2021 | Rockets | 90 | Lakers | 107 |
| April | 9, 2021 | Cavaliers | 78 | Lakers | 98 |
| April | 10, 2021 | Lakers | 101 | Kings | 117 |
| April | 11, 2021 | Pacers | 100 | Lakers | 94 |
| April | 13, 2021 | Lakers | 72 | Blazers | 81 |
| April | 14, 2021 | Lakers | 106 | Bobcats | 92 |
| April | 15, 2021 | Clippers | 111 | Lakers | 97 |
| April | 16, 2021 | Lakers | 105 | Spurs | 85 |
| April | 17, 2021 | Bobcats | 97 | Lakers | 107 |
| April | 18, 2021 | Suns | 106 | Lakers | 112 |
| April | 19, 2021 | Lakers | 87 | Rockets | 90 |
| April | 20, 2021 | Lakers | 88 | Warriors | 99 |
| April | 24, 2021 | Lakers | 101 | Hawks | 75 |
| April | 26, 2021 | Jazz | 92 | Lakers | 111 |
| April | 27, 2021 | Lakers | 106 | Grizzlies | 108 |
| April | 30, 2021 | Lakers | 111 | Knicks | 96 |
| May | 1, 2021 | Raptors | 107 | Lakers | 126 |
| Post | 1, 2021 | Suns | 109 | Lakers | 102 |
| Post | 2, 2021 | Suns | 90 | Lakers | 104 |
| Post | 3, 2021 | Lakers | 91 | Suns | 115 |
| Post | 4, 2021 | Lakers | 110 | Suns | 98 |
| Post | 5, 2021 | Suns | 80 | Lakers | 102 |
| Post | 6, 2021 | Lakers | 100 | Suns | 109 |
| Post | 7, 2021 | Suns | 107 | Lakers | 97 |