| month | day | visitor | score | home | score |
|---|
| November | 3, 2020 | Grizzlies | 85 | Suns | 81 |
| November | 4, 2020 | Pistons | 72 | Grizzlies | 77 |
| November | 7, 2020 | Pelicans | 98 | Grizzlies | 81 |
| November | 10, 2020 | Grizzlies | 70 | Bucks | 94 |
| November | 11, 2020 | Grizzlies | 81 | Rockets | 88 |
| November | 12, 2020 | Knicks | 117 | Grizzlies | 104 |
| November | 14, 2020 | Rockets | 106 | Grizzlies | 103 |
| November | 16, 2020 | 76ers | 89 | Grizzlies | 92 |
| November | 17, 2020 | Grizzlies | 74 | Wolves | 77 |
| November | 19, 2020 | Grizzlies | 70 | Spurs | 88 |
| November | 20, 2020 | Grizzlies | 73 | Pacers | 89 |
| November | 22, 2020 | Wolves | 81 | Grizzlies | 98 |
| November | 23, 2020 | Cavaliers | 86 | Grizzlies | 102 |
| November | 24, 2020 | Grizzlies | 91 | Raptors | 110 |
| November | 29, 2020 | Grizzlies | 69 | Clippers | 101 |
| November | 30, 2020 | Celtics | 85 | Grizzlies | 88 |
| December | 2, 2020 | Sonics | 85 | Grizzlies | 93 |
| December | 9, 2020 | Grizzlies | 78 | 76ers | 79 |
| December | 12, 2020 | Suns | 85 | Grizzlies | 79 |
| December | 14, 2020 | Grizzlies | 84 | Blazers | 91 |
| December | 16, 2020 | Grizzlies | 80 | Pistons | 83 |
| December | 17, 2020 | Pacers | 90 | Grizzlies | 78 |
| December | 19, 2020 | Grizzlies | 97 | Lakers | 127 |
| December | 22, 2020 | Wizards | 87 | Grizzlies | 100 |
| December | 24, 2020 | Heat | 104 | Grizzlies | 93 |
| December | 25, 2020 | Rockets | 88 | Grizzlies | 70 |
| December | 26, 2020 | Grizzlies | 93 | Hawks | 73 |
| December | 27, 2020 | Grizzlies | 75 | Clippers | 102 |
| December | 31, 2020 | Grizzlies | 71 | Bobcats | 85 |
| January | 1, 2021 | Magic | 91 | Grizzlies | 66 |
| January | 2, 2021 | Grizzlies | 63 | Mavericks | 95 |
| January | 4, 2021 | Grizzlies | 68 | Heat | 102 |
| January | 7, 2021 | Suns | 102 | Grizzlies | 76 |
| January | 9, 2021 | Grizzlies | 79 | Nets | 100 |
| January | 11, 2021 | Lakers | 98 | Grizzlies | 67 |
| January | 12, 2021 | Kings | 83 | Grizzlies | 91 |
| January | 13, 2021 | Grizzlies | 83 | Sonics | 113 |
| January | 17, 2021 | Grizzlies | 72 | Cavaliers | 97 |
| January | 18, 2021 | Bulls | 118 | Grizzlies | 71 |
| January | 19, 2021 | Blazers | 87 | Grizzlies | 62 |
| January | 21, 2021 | Grizzlies | 68 | Lakers | 83 |
| January | 22, 2021 | Grizzlies | 98 | Knicks | 119 |
| January | 28, 2021 | Sonics | 84 | Grizzlies | 74 |
| January | 30, 2021 | Grizzlies | 66 | Wolves | 79 |
| February | 1, 2021 | Grizzlies | 72 | Jazz | 107 |
| February | 4, 2021 | Warriors | 87 | Grizzlies | 66 |
| February | 7, 2021 | Grizzlies | 66 | Pelicans | 98 |
| February | 12, 2021 | Grizzlies | 68 | Sonics | 99 |
| February | 13, 2021 | Nuggets | 92 | Grizzlies | 93 |
| February | 14, 2021 | Grizzlies | 45 | Warriors | 71 |
| February | 16, 2021 | Grizzlies | 81 | Kings | 110 |
| February | 18, 2021 | Hawks | 73 | Grizzlies | 81 |
| February | 19, 2021 | Blazers | 76 | Grizzlies | 80 |
| February | 20, 2021 | Bucks | 81 | Grizzlies | 85 |
| February | 25, 2021 | Jazz | 95 | Grizzlies | 83 |
| February | 26, 2021 | Grizzlies | 103 | Kings | 100 |
| March | 2, 2021 | Grizzlies | 96 | Nuggets | 125 |
| March | 3, 2021 | Grizzlies | 67 | Blazers | 91 |
| March | 6, 2021 | Raptors | 73 | Grizzlies | 81 |
| March | 7, 2021 | Spurs | 74 | Grizzlies | 84 |
| March | 9, 2021 | Mavericks | 83 | Grizzlies | 89 |
| March | 14, 2021 | Spurs | 84 | Grizzlies | 73 |
| March | 15, 2021 | Grizzlies | 105 | Magic | 99 |
| March | 16, 2021 | Warriors | 77 | Grizzlies | 76 |
| March | 19, 2021 | Nets | 81 | Grizzlies | 79 |
| March | 20, 2021 | Pelicans | 109 | Grizzlies | 98 |
| March | 22, 2021 | Wolves | 82 | Grizzlies | 85 |
| March | 24, 2021 | Grizzlies | 79 | Suns | 85 |
| March | 28, 2021 | Grizzlies | 69 | Bulls | 104 |
| April | 3, 2021 | Grizzlies | 77 | Rockets | 101 |
| April | 5, 2021 | Clippers | 109 | Grizzlies | 106 |
| April | 6, 2021 | Grizzlies | 78 | Nuggets | 71 |
| April | 10, 2021 | Grizzlies | 62 | Celtics | 71 |
| April | 17, 2021 | Grizzlies | 68 | Wizards | 82 |
| April | 21, 2021 | Grizzlies | 69 | Spurs | 84 |
| April | 22, 2021 | Bobcats | 68 | Grizzlies | 66 |
| April | 23, 2021 | Grizzlies | 83 | Mavericks | 70 |
| April | 25, 2021 | Clippers | 101 | Grizzlies | 88 |
| April | 27, 2021 | Lakers | 106 | Grizzlies | 108 |
| April | 29, 2021 | Nuggets | 76 | Grizzlies | 69 |
| April | 30, 2021 | Grizzlies | 66 | Jazz | 99 |
| May | 1, 2021 | Kings | 115 | Grizzlies | 99 |