| month | day | visitor | score | home | score |
|---|
| November | 3, 2020 | Blazers | 78 | Cavaliers | 85 |
| November | 6, 2020 | Cavaliers | 97 | Knicks | 81 |
| November | 9, 2020 | Cavaliers | 77 | Heat | 84 |
| November | 12, 2020 | Jazz | 95 | Cavaliers | 72 |
| November | 17, 2020 | Cavaliers | 81 | Heat | 97 |
| November | 18, 2020 | Cavaliers | 87 | Pistons | 92 |
| November | 20, 2020 | Bulls | 100 | Cavaliers | 78 |
| November | 21, 2020 | Heat | 97 | Cavaliers | 69 |
| November | 22, 2020 | Cavaliers | 83 | Warriors | 94 |
| November | 23, 2020 | Cavaliers | 86 | Grizzlies | 102 |
| November | 24, 2020 | Cavaliers | 86 | Sonics | 100 |
| November | 25, 2020 | Celtics | 98 | Cavaliers | 80 |
| November | 27, 2020 | Cavaliers | 86 | Wolves | 90 |
| November | 28, 2020 | Pistons | 81 | Cavaliers | 91 |
| November | 30, 2020 | Cavaliers | 89 | Pacers | 77 |
| December | 1, 2020 | Bucks | 91 | Cavaliers | 92 |
| December | 4, 2020 | Cavaliers | 71 | Bucks | 82 |
| December | 6, 2020 | Sonics | 98 | Cavaliers | 84 |
| December | 7, 2020 | Cavaliers | 91 | Magic | 92 |
| December | 10, 2020 | Rockets | 107 | Cavaliers | 100 |
| December | 13, 2020 | Pistons | 73 | Cavaliers | 71 |
| December | 23, 2020 | Cavaliers | 82 | Wizards | 104 |
| December | 26, 2020 | Cavaliers | 90 | Raptors | 108 |
| January | 4, 2021 | Magic | 91 | Cavaliers | 92 |
| January | 6, 2021 | Bobcats | 91 | Cavaliers | 89 |
| January | 7, 2021 | Bulls | 89 | Cavaliers | 91 |
| January | 8, 2021 | Celtics | 101 | Cavaliers | 88 |
| January | 11, 2021 | Cavaliers | 84 | Suns | 96 |
| January | 12, 2021 | Cavaliers | 82 | Jazz | 108 |
| January | 13, 2021 | Cavaliers | 101 | Clippers | 132 |
| January | 14, 2021 | Suns | 102 | Cavaliers | 99 |
| January | 15, 2021 | Knicks | 126 | Cavaliers | 84 |
| January | 17, 2021 | Grizzlies | 72 | Cavaliers | 97 |
| January | 20, 2021 | Cavaliers | 93 | Celtics | 88 |
| January | 21, 2021 | Cavaliers | 97 | Hawks | 74 |
| January | 22, 2021 | Mavericks | 72 | Cavaliers | 82 |
| January | 23, 2021 | Raptors | 113 | Cavaliers | 99 |
| January | 25, 2021 | Cavaliers | 88 | Nuggets | 100 |
| January | 27, 2021 | 76ers | 78 | Cavaliers | 89 |
| January | 31, 2021 | Nets | 83 | Cavaliers | 88 |
| February | 1, 2021 | Cavaliers | 73 | Wizards | 94 |
| February | 4, 2021 | Cavaliers | 74 | Pacers | 76 |
| February | 6, 2021 | Pelicans | 115 | Cavaliers | 91 |
| February | 11, 2021 | Cavaliers | 83 | Nets | 98 |
| February | 13, 2021 | Bucks | 75 | Cavaliers | 62 |
| February | 15, 2021 | Magic | 86 | Cavaliers | 82 |
| February | 16, 2021 | Cavaliers | 72 | Hawks | 74 |
| February | 19, 2021 | Lakers | 99 | Cavaliers | 93 |
| February | 20, 2021 | Cavaliers | 75 | Bulls | 85 |
| February | 21, 2021 | Cavaliers | 76 | Knicks | 107 |
| February | 22, 2021 | Cavaliers | 66 | Raptors | 109 |
| February | 23, 2021 | Cavaliers | 86 | Pelicans | 105 |
| February | 26, 2021 | Bobcats | 76 | Cavaliers | 74 |
| March | 3, 2021 | Cavaliers | 86 | Bobcats | 95 |
| March | 7, 2021 | Warriors | 85 | Cavaliers | 67 |
| March | 9, 2021 | Raptors | 110 | Cavaliers | 92 |
| March | 11, 2021 | Wizards | 99 | Cavaliers | 86 |
| March | 12, 2021 | Cavaliers | 79 | Pistons | 77 |
| March | 17, 2021 | 76ers | 89 | Cavaliers | 84 |
| March | 19, 2021 | Pacers | 80 | Cavaliers | 74 |
| March | 20, 2021 | Cavaliers | 52 | Bobcats | 82 |
| March | 23, 2021 | Clippers | 105 | Cavaliers | 86 |
| March | 25, 2021 | Cavaliers | 67 | 76ers | 80 |
| March | 28, 2021 | Nuggets | 92 | Cavaliers | 67 |
| March | 29, 2021 | Kings | 112 | Cavaliers | 88 |
| March | 30, 2021 | Heat | 107 | Cavaliers | 109 |
| April | 1, 2021 | Hawks | 58 | Cavaliers | 84 |
| April | 5, 2021 | Cavaliers | 73 | Mavericks | 85 |
| April | 8, 2021 | Cavaliers | 77 | Magic | 94 |
| April | 9, 2021 | Cavaliers | 78 | Lakers | 98 |
| April | 11, 2021 | Cavaliers | 66 | Blazers | 97 |
| April | 12, 2021 | Spurs | 90 | Cavaliers | 84 |
| April | 14, 2021 | Wizards | 104 | Cavaliers | 79 |
| April | 17, 2021 | Knicks | 110 | Cavaliers | 85 |
| April | 18, 2021 | Cavaliers | 83 | Celtics | 99 |
| April | 20, 2021 | Cavaliers | 77 | Kings | 110 |
| April | 21, 2021 | Cavaliers | 82 | Rockets | 101 |
| April | 23, 2021 | Cavaliers | 63 | Nets | 81 |
| April | 25, 2021 | Wolves | 91 | Cavaliers | 83 |
| April | 26, 2021 | Cavaliers | 65 | 76ers | 75 |
| April | 27, 2021 | Nets | 91 | Cavaliers | 65 |
| April | 29, 2021 | Cavaliers | 85 | Spurs | 82 |