| month | day | visitor | score | home | score |
|---|
| November | 2, 2020 | 76ers | 70 | Mavericks | 83 |
| November | 3, 2020 | 76ers | 87 | Lakers | 106 |
| November | 4, 2020 | Wizards | 82 | 76ers | 76 |
| November | 5, 2020 | 76ers | 107 | Knicks | 109 |
| November | 7, 2020 | Pistons | 88 | 76ers | 85 |
| November | 8, 2020 | Celtics | 85 | 76ers | 89 |
| November | 9, 2020 | Sonics | 86 | 76ers | 112 |
| November | 10, 2020 | 76ers | 92 | Nuggets | 103 |
| November | 13, 2020 | Pacers | 97 | 76ers | 94 |
| November | 15, 2020 | Nets | 108 | 76ers | 81 |
| November | 16, 2020 | 76ers | 89 | Grizzlies | 92 |
| November | 18, 2020 | Bulls | 75 | 76ers | 88 |
| November | 25, 2020 | 76ers | 93 | Hawks | 80 |
| November | 29, 2020 | 76ers | 71 | Heat | 90 |
| November | 30, 2020 | 76ers | 102 | Nets | 97 |
| December | 3, 2020 | Pistons | 79 | 76ers | 65 |
| December | 5, 2020 | Bucks | 77 | 76ers | 79 |
| December | 6, 2020 | 76ers | 77 | Bucks | 100 |
| December | 9, 2020 | Grizzlies | 78 | 76ers | 79 |
| December | 10, 2020 | 76ers | 65 | Magic | 80 |
| December | 15, 2020 | Magic | 75 | 76ers | 66 |
| December | 16, 2020 | 76ers | 68 | Suns | 95 |
| December | 22, 2020 | 76ers | 69 | Pistons | 73 |
| January | 1, 2021 | 76ers | 66 | Pelicans | 103 |
| January | 3, 2021 | 76ers | 81 | Pacers | 84 |
| January | 4, 2021 | Pelicans | 89 | 76ers | 69 |
| January | 7, 2021 | 76ers | 65 | Bobcats | 82 |
| January | 8, 2021 | Magic | 86 | 76ers | 62 |
| January | 14, 2021 | Bobcats | 69 | 76ers | 80 |
| January | 16, 2021 | 76ers | 72 | Blazers | 101 |
| January | 18, 2021 | 76ers | 67 | Wizards | 86 |
| January | 19, 2021 | Nets | 87 | 76ers | 88 |
| January | 20, 2021 | 76ers | 82 | Nets | 118 |
| January | 24, 2021 | Knicks | 87 | 76ers | 78 |
| January | 26, 2021 | Bulls | 94 | 76ers | 60 |
| January | 27, 2021 | 76ers | 78 | Cavaliers | 89 |
| January | 28, 2021 | Nuggets | 82 | 76ers | 71 |
| January | 31, 2021 | Clippers | 95 | 76ers | 60 |
| February | 4, 2021 | 76ers | 72 | Knicks | 87 |
| February | 5, 2021 | 76ers | 68 | Magic | 105 |
| February | 11, 2021 | Blazers | 94 | 76ers | 82 |
| February | 14, 2021 | Suns | 86 | 76ers | 56 |
| February | 17, 2021 | Pacers | 87 | 76ers | 60 |
| February | 22, 2021 | Bucks | 77 | 76ers | 75 |
| February | 23, 2021 | Lakers | 96 | 76ers | 77 |
| February | 26, 2021 | 76ers | 64 | Jazz | 89 |
| February | 27, 2021 | 76ers | 71 | Hawks | 90 |
| March | 4, 2021 | Knicks | 96 | 76ers | 107 |
| March | 5, 2021 | 76ers | 57 | Wizards | 81 |
| March | 6, 2021 | Spurs | 75 | 76ers | 67 |
| March | 7, 2021 | Hawks | 64 | 76ers | 79 |
| March | 8, 2021 | Rockets | 84 | 76ers | 88 |
| March | 12, 2021 | Warriors | 80 | 76ers | 73 |
| March | 13, 2021 | 76ers | 71 | Pistons | 75 |
| March | 15, 2021 | Bobcats | 79 | 76ers | 67 |
| March | 17, 2021 | 76ers | 89 | Cavaliers | 84 |
| March | 18, 2021 | 76ers | 66 | Celtics | 91 |
| March | 19, 2021 | 76ers | 68 | Rockets | 89 |
| March | 20, 2021 | 76ers | 58 | Bulls | 87 |
| March | 21, 2021 | 76ers | 71 | Clippers | 98 |
| March | 24, 2021 | 76ers | 73 | Pacers | 100 |
| March | 25, 2021 | Cavaliers | 67 | 76ers | 80 |
| March | 27, 2021 | Wizards | 78 | 76ers | 63 |
| March | 29, 2021 | Wolves | 100 | 76ers | 82 |
| March | 30, 2021 | 76ers | 60 | Celtics | 66 |
| March | 31, 2021 | 76ers | 76 | Warriors | 91 |
| April | 1, 2021 | Raptors | 67 | 76ers | 85 |
| April | 2, 2021 | Mavericks | 74 | 76ers | 71 |
| April | 4, 2021 | 76ers | 80 | Wolves | 89 |
| April | 9, 2021 | 76ers | 75 | Kings | 86 |
| April | 10, 2021 | 76ers | 91 | Raptors | 103 |
| April | 11, 2021 | Raptors | 95 | 76ers | 64 |
| April | 15, 2021 | Heat | 73 | 76ers | 62 |
| April | 16, 2021 | Kings | 89 | 76ers | 72 |
| April | 23, 2021 | 76ers | 70 | Spurs | 82 |
| April | 24, 2021 | 76ers | 57 | Bucks | 101 |
| April | 25, 2021 | Hawks | 58 | 76ers | 72 |
| April | 26, 2021 | Cavaliers | 65 | 76ers | 75 |
| April | 28, 2021 | Jazz | 65 | 76ers | 70 |
| April | 29, 2021 | 76ers | 68 | Sonics | 76 |
| April | 30, 2021 | 76ers | 69 | Bulls | 110 |
| May | 1, 2021 | 76ers | 77 | Heat | 83 |